Mechanism-based tuning of insect 3,4-dihydroxyphenylacetaldehyde synthase for synthetic bioproduction of benzylisoquinoline alkaloids

Bioproduction of tetrahydropapaveroline (THP) is limited by the specificity of monoamine oxidase (MAO). Here, the authors identify an insect 3,4-dihydroxyphenylacetaldehyde synthase (DHPAAS) that can bypass MAO for direct aldehyde production and demonstrate bifunctional switching of DHPAAS for effic...

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Autores principales:	Christopher J. Vavricka, Takanobu Yoshida, Yuki Kuriya, Shunsuke Takahashi, Teppei Ogawa, Fumie Ono, Kazuko Agari, Hiromasa Kiyota, Jianyong Li, Jun Ishii, Kenji Tsuge, Hiromichi Minami, Michihiro Araki, Tomohisa Hasunuma, Akihiko Kondo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cff5bceaa4c341b49a36d8f2870f8cb6
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spelling	oai:doaj.org-article:cff5bceaa4c341b49a36d8f2870f8cb62021-12-02T17:31:52ZMechanism-based tuning of insect 3,4-dihydroxyphenylacetaldehyde synthase for synthetic bioproduction of benzylisoquinoline alkaloids10.1038/s41467-019-09610-22041-1723https://doaj.org/article/cff5bceaa4c341b49a36d8f2870f8cb62019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09610-2https://doaj.org/toc/2041-1723Bioproduction of tetrahydropapaveroline (THP) is limited by the specificity of monoamine oxidase (MAO). Here, the authors identify an insect 3,4-dihydroxyphenylacetaldehyde synthase (DHPAAS) that can bypass MAO for direct aldehyde production and demonstrate bifunctional switching of DHPAAS for efficient THP production.Christopher J. VavrickaTakanobu YoshidaYuki KuriyaShunsuke TakahashiTeppei OgawaFumie OnoKazuko AgariHiromasa KiyotaJianyong LiJun IshiiKenji TsugeHiromichi MinamiMichihiro ArakiTomohisa HasunumaAkihiko KondoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Christopher J. Vavricka Takanobu Yoshida Yuki Kuriya Shunsuke Takahashi Teppei Ogawa Fumie Ono Kazuko Agari Hiromasa Kiyota Jianyong Li Jun Ishii Kenji Tsuge Hiromichi Minami Michihiro Araki Tomohisa Hasunuma Akihiko Kondo Mechanism-based tuning of insect 3,4-dihydroxyphenylacetaldehyde synthase for synthetic bioproduction of benzylisoquinoline alkaloids
description	Bioproduction of tetrahydropapaveroline (THP) is limited by the specificity of monoamine oxidase (MAO). Here, the authors identify an insect 3,4-dihydroxyphenylacetaldehyde synthase (DHPAAS) that can bypass MAO for direct aldehyde production and demonstrate bifunctional switching of DHPAAS for efficient THP production.
format	article
author	Christopher J. Vavricka Takanobu Yoshida Yuki Kuriya Shunsuke Takahashi Teppei Ogawa Fumie Ono Kazuko Agari Hiromasa Kiyota Jianyong Li Jun Ishii Kenji Tsuge Hiromichi Minami Michihiro Araki Tomohisa Hasunuma Akihiko Kondo
author_facet	Christopher J. Vavricka Takanobu Yoshida Yuki Kuriya Shunsuke Takahashi Teppei Ogawa Fumie Ono Kazuko Agari Hiromasa Kiyota Jianyong Li Jun Ishii Kenji Tsuge Hiromichi Minami Michihiro Araki Tomohisa Hasunuma Akihiko Kondo
author_sort	Christopher J. Vavricka
title	Mechanism-based tuning of insect 3,4-dihydroxyphenylacetaldehyde synthase for synthetic bioproduction of benzylisoquinoline alkaloids
title_short	Mechanism-based tuning of insect 3,4-dihydroxyphenylacetaldehyde synthase for synthetic bioproduction of benzylisoquinoline alkaloids
title_full	Mechanism-based tuning of insect 3,4-dihydroxyphenylacetaldehyde synthase for synthetic bioproduction of benzylisoquinoline alkaloids
title_fullStr	Mechanism-based tuning of insect 3,4-dihydroxyphenylacetaldehyde synthase for synthetic bioproduction of benzylisoquinoline alkaloids
title_full_unstemmed	Mechanism-based tuning of insect 3,4-dihydroxyphenylacetaldehyde synthase for synthetic bioproduction of benzylisoquinoline alkaloids
title_sort	mechanism-based tuning of insect 3,4-dihydroxyphenylacetaldehyde synthase for synthetic bioproduction of benzylisoquinoline alkaloids
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/cff5bceaa4c341b49a36d8f2870f8cb6
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Mechanism-based tuning of insect 3,4-dihydroxyphenylacetaldehyde synthase for synthetic bioproduction of benzylisoquinoline alkaloids

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