New Insights Into the Effects of Individual Chinese Herbal Medicines on Chronic Kidney Disease

The clinical and experimental study into the effects of Chinese herbal medicines on chronic kidney disease has evolved over the past 40 years with new insight into their mechanism and evidence of their clinical effects. Among the many traditional Chinese herbs examined in chronic renal disease, five...

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Autores principales:	Minghai Shao, Chaoyang Ye, George Bayliss, Shougang Zhuang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	renal fibrosis Chinese herbs monomers chronic kidney disease Abelmoschus manihot Salvia miltiorrhiza Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/cff61ecacd6a498292188c8c2df97140
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spelling	oai:doaj.org-article:cff61ecacd6a498292188c8c2df971402021-11-04T05:51:31ZNew Insights Into the Effects of Individual Chinese Herbal Medicines on Chronic Kidney Disease1663-981210.3389/fphar.2021.774414https://doaj.org/article/cff61ecacd6a498292188c8c2df971402021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphar.2021.774414/fullhttps://doaj.org/toc/1663-9812The clinical and experimental study into the effects of Chinese herbal medicines on chronic kidney disease has evolved over the past 40 years with new insight into their mechanism and evidence of their clinical effects. Among the many traditional Chinese herbs examined in chronic renal disease, five were found to have evidence of sufficient clinical efficacy, high frequency of use, and well-studied mechanism. They are: Abelmoschus manihot and Huangkui capsule, Salvia miltiorrhiza and its components (tanshinone II A, salvianolic acid A and B); Rhizoma coptidis and its monomer berberine; Tripterygium wilfordii and its components (triptolide, tripterygium glycosides); Kudzu root Pueraria and its monomer Puerarin. These Chinese herbal medications have pharmaceutical effects against fibrosis, inflammation and oxidative stress and also promote renal repair and regeneration. This article reviews their clinical efficacy, anti-fibrotic effects in animal models, and molecular mechanism of action.Minghai ShaoChaoyang YeGeorge BaylissShougang ZhuangShougang ZhuangFrontiers Media S.A.articlerenal fibrosisChinese herbsmonomerschronic kidney diseaseAbelmoschus manihotSalvia miltiorrhizaTherapeutics. PharmacologyRM1-950ENFrontiers in Pharmacology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	renal fibrosis Chinese herbs monomers chronic kidney disease Abelmoschus manihot Salvia miltiorrhiza Therapeutics. Pharmacology RM1-950
spellingShingle	renal fibrosis Chinese herbs monomers chronic kidney disease Abelmoschus manihot Salvia miltiorrhiza Therapeutics. Pharmacology RM1-950 Minghai Shao Chaoyang Ye George Bayliss Shougang Zhuang Shougang Zhuang New Insights Into the Effects of Individual Chinese Herbal Medicines on Chronic Kidney Disease
description	The clinical and experimental study into the effects of Chinese herbal medicines on chronic kidney disease has evolved over the past 40 years with new insight into their mechanism and evidence of their clinical effects. Among the many traditional Chinese herbs examined in chronic renal disease, five were found to have evidence of sufficient clinical efficacy, high frequency of use, and well-studied mechanism. They are: Abelmoschus manihot and Huangkui capsule, Salvia miltiorrhiza and its components (tanshinone II A, salvianolic acid A and B); Rhizoma coptidis and its monomer berberine; Tripterygium wilfordii and its components (triptolide, tripterygium glycosides); Kudzu root Pueraria and its monomer Puerarin. These Chinese herbal medications have pharmaceutical effects against fibrosis, inflammation and oxidative stress and also promote renal repair and regeneration. This article reviews their clinical efficacy, anti-fibrotic effects in animal models, and molecular mechanism of action.
format	article
author	Minghai Shao Chaoyang Ye George Bayliss Shougang Zhuang Shougang Zhuang
author_facet	Minghai Shao Chaoyang Ye George Bayliss Shougang Zhuang Shougang Zhuang
author_sort	Minghai Shao
title	New Insights Into the Effects of Individual Chinese Herbal Medicines on Chronic Kidney Disease
title_short	New Insights Into the Effects of Individual Chinese Herbal Medicines on Chronic Kidney Disease
title_full	New Insights Into the Effects of Individual Chinese Herbal Medicines on Chronic Kidney Disease
title_fullStr	New Insights Into the Effects of Individual Chinese Herbal Medicines on Chronic Kidney Disease
title_full_unstemmed	New Insights Into the Effects of Individual Chinese Herbal Medicines on Chronic Kidney Disease
title_sort	new insights into the effects of individual chinese herbal medicines on chronic kidney disease
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/cff61ecacd6a498292188c8c2df97140
work_keys_str_mv	AT minghaishao newinsightsintotheeffectsofindividualchineseherbalmedicinesonchronickidneydisease AT chaoyangye newinsightsintotheeffectsofindividualchineseherbalmedicinesonchronickidneydisease AT georgebayliss newinsightsintotheeffectsofindividualchineseherbalmedicinesonchronickidneydisease AT shougangzhuang newinsightsintotheeffectsofindividualchineseherbalmedicinesonchronickidneydisease AT shougangzhuang newinsightsintotheeffectsofindividualchineseherbalmedicinesonchronickidneydisease
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New Insights Into the Effects of Individual Chinese Herbal Medicines on Chronic Kidney Disease

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