Cardiovascular morbidities in postoperative colorectal cancer patients

Abstract This retrospective observational study investigated the long-term prevalence of new-onset cardiovascular disease (CVD) and the predictive role of atherosclerotic plaque in the aorta and iliac arteries for CVD in postoperative colorectal cancer (CRC) patients who received surgical treatment...

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Autores principales:	Hyangkyoung Kim, In Ja Park, Youngjin Han, Tae-Won Kwon, Yong-Pil Cho
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cff8172dc1694eb1b9a93c2031b01dea
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spelling	oai:doaj.org-article:cff8172dc1694eb1b9a93c2031b01dea2021-11-08T10:56:09ZCardiovascular morbidities in postoperative colorectal cancer patients10.1038/s41598-021-00735-32045-2322https://doaj.org/article/cff8172dc1694eb1b9a93c2031b01dea2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-00735-3https://doaj.org/toc/2045-2322Abstract This retrospective observational study investigated the long-term prevalence of new-onset cardiovascular disease (CVD) and the predictive role of atherosclerotic plaque in the aorta and iliac arteries for CVD in postoperative colorectal cancer (CRC) patients who received surgical treatment between 2014 and 2015. CVD included coronary or cerebrovascular diseases which required treatment and new-onset CVD included peri-and postoperatively diagnosed CVDs or aggravated CVDs that required additional treatment during follow-up. Of the 2,875 patients included in this study, the prevalence of CVD was 8.9% (255/2875) and 141 (4.9%) developed new-onset CVD. Maximum arterial stenosis in the aorta or iliac arteries occurred in 40.8 ± 18.6% of patients with new-onset CVD and 11.6 ± 13.8% of patients without new-onset CVD (p < 0.001). The mean new-onset CVD-free survival time in patients with > 30% and < 30% stenoses were 52.5 [95% confidence intervals (CIs) 50.0–54.9] and 66.5 (95% CIs 66.2–66.8) months, respectively (p < 0.001). The area under the receiver operating characteristic curve of the maximal arterial stenosis for new-onset CVD was 0.911. These results suggest that CRC patients are at risk for developing new-onset CVD, which is associated with reduced survival. Atherosclerotic burden in the aorta or both iliac arteries may help predict future CVD events.Hyangkyoung KimIn Ja ParkYoungjin HanTae-Won KwonYong-Pil ChoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hyangkyoung Kim In Ja Park Youngjin Han Tae-Won Kwon Yong-Pil Cho Cardiovascular morbidities in postoperative colorectal cancer patients
description	Abstract This retrospective observational study investigated the long-term prevalence of new-onset cardiovascular disease (CVD) and the predictive role of atherosclerotic plaque in the aorta and iliac arteries for CVD in postoperative colorectal cancer (CRC) patients who received surgical treatment between 2014 and 2015. CVD included coronary or cerebrovascular diseases which required treatment and new-onset CVD included peri-and postoperatively diagnosed CVDs or aggravated CVDs that required additional treatment during follow-up. Of the 2,875 patients included in this study, the prevalence of CVD was 8.9% (255/2875) and 141 (4.9%) developed new-onset CVD. Maximum arterial stenosis in the aorta or iliac arteries occurred in 40.8 ± 18.6% of patients with new-onset CVD and 11.6 ± 13.8% of patients without new-onset CVD (p < 0.001). The mean new-onset CVD-free survival time in patients with > 30% and < 30% stenoses were 52.5 [95% confidence intervals (CIs) 50.0–54.9] and 66.5 (95% CIs 66.2–66.8) months, respectively (p < 0.001). The area under the receiver operating characteristic curve of the maximal arterial stenosis for new-onset CVD was 0.911. These results suggest that CRC patients are at risk for developing new-onset CVD, which is associated with reduced survival. Atherosclerotic burden in the aorta or both iliac arteries may help predict future CVD events.
format	article
author	Hyangkyoung Kim In Ja Park Youngjin Han Tae-Won Kwon Yong-Pil Cho
author_facet	Hyangkyoung Kim In Ja Park Youngjin Han Tae-Won Kwon Yong-Pil Cho
author_sort	Hyangkyoung Kim
title	Cardiovascular morbidities in postoperative colorectal cancer patients
title_short	Cardiovascular morbidities in postoperative colorectal cancer patients
title_full	Cardiovascular morbidities in postoperative colorectal cancer patients
title_fullStr	Cardiovascular morbidities in postoperative colorectal cancer patients
title_full_unstemmed	Cardiovascular morbidities in postoperative colorectal cancer patients
title_sort	cardiovascular morbidities in postoperative colorectal cancer patients
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/cff8172dc1694eb1b9a93c2031b01dea
work_keys_str_mv	AT hyangkyoungkim cardiovascularmorbiditiesinpostoperativecolorectalcancerpatients AT injapark cardiovascularmorbiditiesinpostoperativecolorectalcancerpatients AT youngjinhan cardiovascularmorbiditiesinpostoperativecolorectalcancerpatients AT taewonkwon cardiovascularmorbiditiesinpostoperativecolorectalcancerpatients AT yongpilcho cardiovascularmorbiditiesinpostoperativecolorectalcancerpatients
_version_	1718442569662201856

Cardiovascular morbidities in postoperative colorectal cancer patients

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