Common Variants in OPG Confer Risk to Bone Mineral Density Variation and Osteoporosis Fractures

Abstract Although many common variants have been identified for bone mineral density (BMD) and osteoporosis fractures, all the identified risk variants could only explain a small portion of heritability of BMD and osteoporosis fractures. OPG belongs to the tumor necrosis factor receptor superfamily,...

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Autores principales:	Xiaoyong Sheng, Guangyong Cai, Xingjun Gong, Zouying Yao, Ye Zhu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cffb6c8ee0a14113bd5005c8f3594d22
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spelling	oai:doaj.org-article:cffb6c8ee0a14113bd5005c8f3594d222021-12-02T11:52:32ZCommon Variants in OPG Confer Risk to Bone Mineral Density Variation and Osteoporosis Fractures10.1038/s41598-017-01579-62045-2322https://doaj.org/article/cffb6c8ee0a14113bd5005c8f3594d222017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01579-6https://doaj.org/toc/2045-2322Abstract Although many common variants have been identified for bone mineral density (BMD) and osteoporosis fractures, all the identified risk variants could only explain a small portion of heritability of BMD and osteoporosis fractures. OPG belongs to the tumor necrosis factor receptor superfamily, which plays a crucial role in bone remodeling and is thus a promising candidate gene of osteoporosis. Several studies have explored the association of OPG variants with BMD or osteoporosis fractures, however, the results remain inconsistent among different populations. In the study, we first assessed the relationship between OPG variants and BMD or osteoporosis fractures in our sample size (227 subjects with postmenopausal osteoporosis and 189 controls), and then performed a systematic meta-analysis. Among the nine SNPs genotyped, rs6469804 and rs2073618 showed significant associations with both BMD and osteoporotic fractures, while rs3102735 was only associated with BMD in our samples (P < 0.05). For meta-analyses, data for a total of 12 SNPs were pooled (4725 patients and 37804 controls), and five SNPs, including rs6993813, rs6469804, rs3134070, rs2073618 and rs3102734, showed association with osteoporosis fractures (P < 0.05). On light of the above analysis, we believe that OPG is one promising susceptibility gene of BMD or osteoporotic fractures.Xiaoyong ShengGuangyong CaiXingjun GongZouying YaoYe ZhuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xiaoyong Sheng Guangyong Cai Xingjun Gong Zouying Yao Ye Zhu Common Variants in OPG Confer Risk to Bone Mineral Density Variation and Osteoporosis Fractures
description	Abstract Although many common variants have been identified for bone mineral density (BMD) and osteoporosis fractures, all the identified risk variants could only explain a small portion of heritability of BMD and osteoporosis fractures. OPG belongs to the tumor necrosis factor receptor superfamily, which plays a crucial role in bone remodeling and is thus a promising candidate gene of osteoporosis. Several studies have explored the association of OPG variants with BMD or osteoporosis fractures, however, the results remain inconsistent among different populations. In the study, we first assessed the relationship between OPG variants and BMD or osteoporosis fractures in our sample size (227 subjects with postmenopausal osteoporosis and 189 controls), and then performed a systematic meta-analysis. Among the nine SNPs genotyped, rs6469804 and rs2073618 showed significant associations with both BMD and osteoporotic fractures, while rs3102735 was only associated with BMD in our samples (P < 0.05). For meta-analyses, data for a total of 12 SNPs were pooled (4725 patients and 37804 controls), and five SNPs, including rs6993813, rs6469804, rs3134070, rs2073618 and rs3102734, showed association with osteoporosis fractures (P < 0.05). On light of the above analysis, we believe that OPG is one promising susceptibility gene of BMD or osteoporotic fractures.
format	article
author	Xiaoyong Sheng Guangyong Cai Xingjun Gong Zouying Yao Ye Zhu
author_facet	Xiaoyong Sheng Guangyong Cai Xingjun Gong Zouying Yao Ye Zhu
author_sort	Xiaoyong Sheng
title	Common Variants in OPG Confer Risk to Bone Mineral Density Variation and Osteoporosis Fractures
title_short	Common Variants in OPG Confer Risk to Bone Mineral Density Variation and Osteoporosis Fractures
title_full	Common Variants in OPG Confer Risk to Bone Mineral Density Variation and Osteoporosis Fractures
title_fullStr	Common Variants in OPG Confer Risk to Bone Mineral Density Variation and Osteoporosis Fractures
title_full_unstemmed	Common Variants in OPG Confer Risk to Bone Mineral Density Variation and Osteoporosis Fractures
title_sort	common variants in opg confer risk to bone mineral density variation and osteoporosis fractures
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/cffb6c8ee0a14113bd5005c8f3594d22
work_keys_str_mv	AT xiaoyongsheng commonvariantsinopgconferrisktobonemineraldensityvariationandosteoporosisfractures AT guangyongcai commonvariantsinopgconferrisktobonemineraldensityvariationandosteoporosisfractures AT xingjungong commonvariantsinopgconferrisktobonemineraldensityvariationandosteoporosisfractures AT zouyingyao commonvariantsinopgconferrisktobonemineraldensityvariationandosteoporosisfractures AT yezhu commonvariantsinopgconferrisktobonemineraldensityvariationandosteoporosisfractures
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Common Variants in OPG Confer Risk to Bone Mineral Density Variation and Osteoporosis Fractures

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