Neurologic abnormalities in HIV-1 infected children in the era of combination antiretroviral therapy.

<h4>Background</h4>Pediatric HIV-1 infection is associated with neurologic abnormalities. In recent years, the neurological outcome of HIV-1 infected children has substantially improved with combination antiretroviral therapy (cART). However, data regarding the long-term effect of cART a...

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Autores principales:	Lotus A van Arnhem, Madeleine J Bunders, Henriette J Scherpbier, Charles B L M Majoie, Liesbeth Reneman, Olivier Frinking, Bwee Tien Poll-The, Taco W Kuijpers, Dasja Pajkrt
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cffd2b0a20704354a9c59f1681bb40b8
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spelling	oai:doaj.org-article:cffd2b0a20704354a9c59f1681bb40b82021-11-18T07:45:35ZNeurologic abnormalities in HIV-1 infected children in the era of combination antiretroviral therapy.1932-620310.1371/journal.pone.0064398https://doaj.org/article/cffd2b0a20704354a9c59f1681bb40b82013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23691211/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Pediatric HIV-1 infection is associated with neurologic abnormalities. In recent years, the neurological outcome of HIV-1 infected children has substantially improved with combination antiretroviral therapy (cART). However, data regarding the long-term effect of cART and neurologic outcome are limited.<h4>Methods</h4>In the Pediatric Amsterdam Cohort on HIV-1 study, 59 perinatally HIV-1 infected children were evaluated from 1992-2010. All children underwent neurological examination and neuro-imaging studies, including CT-scan and/or MRI imaging. Fisher exact and Kruskal-Wallis tests were used to compare clinical deviations of neuro-imaging studies with HIV-1 related parameters, including CD4(+) T cell count, HIV-1 viral load in blood and cerebrospinal fluid (CSF), and duration of cART as well as neurological examination.<h4>Results</h4>Abnormal neurologic examinations in these HIV-1 infected children included language impairment (22%), abnormal muscle tone (hyper/hypotonia) (14%) and delay in reaching developmental milestones (12%). Ventricular enlargement and sulcal widening (29%) and white matter lesions (38%) were prominent findings. White matter lesions were positively correlated with HIV-1 viral load levels. In a small follow-up sub study white matter lesions did not improve while children with ventricular enlargement and sulcal widening showed improvements whilst being treated with cART.<h4>Conclusions</h4>In the current era of cART HIV-1 infected children still frequently show neurological impairments together with abnormal neuro-imaging.Lotus A van ArnhemMadeleine J BundersHenriette J ScherpbierCharles B L M MajoieLiesbeth RenemanOlivier FrinkingBwee Tien Poll-TheTaco W KuijpersDasja PajkrtPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 5, p e64398 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lotus A van Arnhem Madeleine J Bunders Henriette J Scherpbier Charles B L M Majoie Liesbeth Reneman Olivier Frinking Bwee Tien Poll-The Taco W Kuijpers Dasja Pajkrt Neurologic abnormalities in HIV-1 infected children in the era of combination antiretroviral therapy.
description	<h4>Background</h4>Pediatric HIV-1 infection is associated with neurologic abnormalities. In recent years, the neurological outcome of HIV-1 infected children has substantially improved with combination antiretroviral therapy (cART). However, data regarding the long-term effect of cART and neurologic outcome are limited.<h4>Methods</h4>In the Pediatric Amsterdam Cohort on HIV-1 study, 59 perinatally HIV-1 infected children were evaluated from 1992-2010. All children underwent neurological examination and neuro-imaging studies, including CT-scan and/or MRI imaging. Fisher exact and Kruskal-Wallis tests were used to compare clinical deviations of neuro-imaging studies with HIV-1 related parameters, including CD4(+) T cell count, HIV-1 viral load in blood and cerebrospinal fluid (CSF), and duration of cART as well as neurological examination.<h4>Results</h4>Abnormal neurologic examinations in these HIV-1 infected children included language impairment (22%), abnormal muscle tone (hyper/hypotonia) (14%) and delay in reaching developmental milestones (12%). Ventricular enlargement and sulcal widening (29%) and white matter lesions (38%) were prominent findings. White matter lesions were positively correlated with HIV-1 viral load levels. In a small follow-up sub study white matter lesions did not improve while children with ventricular enlargement and sulcal widening showed improvements whilst being treated with cART.<h4>Conclusions</h4>In the current era of cART HIV-1 infected children still frequently show neurological impairments together with abnormal neuro-imaging.
format	article
author	Lotus A van Arnhem Madeleine J Bunders Henriette J Scherpbier Charles B L M Majoie Liesbeth Reneman Olivier Frinking Bwee Tien Poll-The Taco W Kuijpers Dasja Pajkrt
author_facet	Lotus A van Arnhem Madeleine J Bunders Henriette J Scherpbier Charles B L M Majoie Liesbeth Reneman Olivier Frinking Bwee Tien Poll-The Taco W Kuijpers Dasja Pajkrt
author_sort	Lotus A van Arnhem
title	Neurologic abnormalities in HIV-1 infected children in the era of combination antiretroviral therapy.
title_short	Neurologic abnormalities in HIV-1 infected children in the era of combination antiretroviral therapy.
title_full	Neurologic abnormalities in HIV-1 infected children in the era of combination antiretroviral therapy.
title_fullStr	Neurologic abnormalities in HIV-1 infected children in the era of combination antiretroviral therapy.
title_full_unstemmed	Neurologic abnormalities in HIV-1 infected children in the era of combination antiretroviral therapy.
title_sort	neurologic abnormalities in hiv-1 infected children in the era of combination antiretroviral therapy.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/cffd2b0a20704354a9c59f1681bb40b8
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Neurologic abnormalities in HIV-1 infected children in the era of combination antiretroviral therapy.

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