Are Sarcopenia and Myosteatosis in Elderly Patients with Pelvic Ring Injury Related to Mortality, Physical Functioning and Quality of Life?
The purpose of this study was to evaluate the prevalence of sarcopenia and/or myosteatosis in elderly patients with pelvic ring injuries and their influence on mortality, patient-perceived physical functioning and quality of life (QoL). A multicenter retrospective cohort study was conducted includin...
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MDPI AG
2021
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oai:doaj.org-article:cffdb78d28d54e638f12dcd6bbe02cde2021-11-11T17:32:00ZAre Sarcopenia and Myosteatosis in Elderly Patients with Pelvic Ring Injury Related to Mortality, Physical Functioning and Quality of Life?10.3390/jcm102148742077-0383https://doaj.org/article/cffdb78d28d54e638f12dcd6bbe02cde2021-10-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/21/4874https://doaj.org/toc/2077-0383The purpose of this study was to evaluate the prevalence of sarcopenia and/or myosteatosis in elderly patients with pelvic ring injuries and their influence on mortality, patient-perceived physical functioning and quality of life (QoL). A multicenter retrospective cohort study was conducted including elderly patients aged ≥ 65 treated for a pelvic ring injury. Cross-sectional computed tomography (CT) muscle measurements were obtained to determine the presence of sarcopenia and/or myosteatosis. Kaplan–Meier analysis was used for survival analysis, and Cox proportional hazards regression analysis was used to determine risk factors for mortality. Patient-reported outcome measures for physical functioning (SMFA) and QoL (EQ-5D) were used. Multivariable linear regression analyses were used to determine the effect of sarcopenia and myosteatosis on patient-perceived physical functioning and QoL. Data to determine sarcopenia and myosteatosis were available for 199 patients, with a mean follow-up of 2.4 ± 2.2 years: 66 patients (33%) were diagnosed with sarcopenia and 65 (32%) with myosteatosis, while 30 of them (15%) had both. Mortality rates in patients at 1 and 3 years without sarcopenia and myosteatosis were 13% and 21%, compared to 11% and 36% in patients with sarcopenia, 17% and 31% in patients with myosteatosis and 27% and 43% in patients with both. Higher age at the time of injury and a higher Charlson Comorbidity Index (CCI) were independent risk factors for mortality. Patient-reported mental and emotional problems were significantly increased in patients with sarcopenia.Hester BanierinkJulia J. C. BombachKaj ten DuisFrank F. A. IJpmaErik HeinemanSven H. van HeldenRobert J. NijveldtAlain R. ViddeleerInge H. F. ReiningaMDPI AGarticlepelvic ring injurysarcopeniamyosteatosissurvivalquality of lifephysical functioningMedicineRENJournal of Clinical Medicine, Vol 10, Iss 4874, p 4874 (2021) |
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DOAJ |
| collection |
DOAJ |
| language |
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| topic |
pelvic ring injury sarcopenia myosteatosis survival quality of life physical functioning Medicine R |
| spellingShingle |
pelvic ring injury sarcopenia myosteatosis survival quality of life physical functioning Medicine R Hester Banierink Julia J. C. Bombach Kaj ten Duis Frank F. A. IJpma Erik Heineman Sven H. van Helden Robert J. Nijveldt Alain R. Viddeleer Inge H. F. Reininga Are Sarcopenia and Myosteatosis in Elderly Patients with Pelvic Ring Injury Related to Mortality, Physical Functioning and Quality of Life? |
| description |
The purpose of this study was to evaluate the prevalence of sarcopenia and/or myosteatosis in elderly patients with pelvic ring injuries and their influence on mortality, patient-perceived physical functioning and quality of life (QoL). A multicenter retrospective cohort study was conducted including elderly patients aged ≥ 65 treated for a pelvic ring injury. Cross-sectional computed tomography (CT) muscle measurements were obtained to determine the presence of sarcopenia and/or myosteatosis. Kaplan–Meier analysis was used for survival analysis, and Cox proportional hazards regression analysis was used to determine risk factors for mortality. Patient-reported outcome measures for physical functioning (SMFA) and QoL (EQ-5D) were used. Multivariable linear regression analyses were used to determine the effect of sarcopenia and myosteatosis on patient-perceived physical functioning and QoL. Data to determine sarcopenia and myosteatosis were available for 199 patients, with a mean follow-up of 2.4 ± 2.2 years: 66 patients (33%) were diagnosed with sarcopenia and 65 (32%) with myosteatosis, while 30 of them (15%) had both. Mortality rates in patients at 1 and 3 years without sarcopenia and myosteatosis were 13% and 21%, compared to 11% and 36% in patients with sarcopenia, 17% and 31% in patients with myosteatosis and 27% and 43% in patients with both. Higher age at the time of injury and a higher Charlson Comorbidity Index (CCI) were independent risk factors for mortality. Patient-reported mental and emotional problems were significantly increased in patients with sarcopenia. |
| format |
article |
| author |
Hester Banierink Julia J. C. Bombach Kaj ten Duis Frank F. A. IJpma Erik Heineman Sven H. van Helden Robert J. Nijveldt Alain R. Viddeleer Inge H. F. Reininga |
| author_facet |
Hester Banierink Julia J. C. Bombach Kaj ten Duis Frank F. A. IJpma Erik Heineman Sven H. van Helden Robert J. Nijveldt Alain R. Viddeleer Inge H. F. Reininga |
| author_sort |
Hester Banierink |
| title |
Are Sarcopenia and Myosteatosis in Elderly Patients with Pelvic Ring Injury Related to Mortality, Physical Functioning and Quality of Life? |
| title_short |
Are Sarcopenia and Myosteatosis in Elderly Patients with Pelvic Ring Injury Related to Mortality, Physical Functioning and Quality of Life? |
| title_full |
Are Sarcopenia and Myosteatosis in Elderly Patients with Pelvic Ring Injury Related to Mortality, Physical Functioning and Quality of Life? |
| title_fullStr |
Are Sarcopenia and Myosteatosis in Elderly Patients with Pelvic Ring Injury Related to Mortality, Physical Functioning and Quality of Life? |
| title_full_unstemmed |
Are Sarcopenia and Myosteatosis in Elderly Patients with Pelvic Ring Injury Related to Mortality, Physical Functioning and Quality of Life? |
| title_sort |
are sarcopenia and myosteatosis in elderly patients with pelvic ring injury related to mortality, physical functioning and quality of life? |
| publisher |
MDPI AG |
| publishDate |
2021 |
| url |
https://doaj.org/article/cffdb78d28d54e638f12dcd6bbe02cde |
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