Cancer-associated fibroblast heterogeneity in axillary lymph nodes drives metastases in breast cancer through complementary mechanisms

Cancer-associated fibroblast heterogeneity in axillary lymph nodes drives metastases in breast cancer through complementary mechanisms

Cancer associated fibroblasts are known to promote the progression of cancer. Here, the authors show that two particular subsets of cancer associated fibroblasts induce metastasis but work via distinct mechanisms including, chemokine signalling and Notch signalling.

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Autores principales: Floriane Pelon, Brigitte Bourachot, Yann Kieffer, Ilaria Magagna, Fanny Mermet-Meillon, Isabelle Bonnet, Ana Costa, Anne-Marie Givel, Youmna Attieh, Jorge Barbazan, Claire Bonneau, Laetitia Fuhrmann, Stéphanie Descroix, Danijela Vignjevic, Pascal Silberzan, Maria Carla Parrini, Anne Vincent-Salomon, Fatima Mechta-Grigoriou
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/cffe5431806244e5b3bdeb1e1726578f
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spelling oai:doaj.org-article:cffe5431806244e5b3bdeb1e1726578f2021-12-02T14:40:51ZCancer-associated fibroblast heterogeneity in axillary lymph nodes drives metastases in breast cancer through complementary mechanisms10.1038/s41467-019-14134-w2041-1723https://doaj.org/article/cffe5431806244e5b3bdeb1e1726578f2020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14134-whttps://doaj.org/toc/2041-1723Cancer associated fibroblasts are known to promote the progression of cancer. Here, the authors show that two particular subsets of cancer associated fibroblasts induce metastasis but work via distinct mechanisms including, chemokine signalling and Notch signalling.Floriane PelonBrigitte BourachotYann KiefferIlaria MagagnaFanny Mermet-MeillonIsabelle BonnetAna CostaAnne-Marie GivelYoumna AttiehJorge BarbazanClaire BonneauLaetitia FuhrmannStéphanie DescroixDanijela VignjevicPascal SilberzanMaria Carla ParriniAnne Vincent-SalomonFatima Mechta-GrigoriouNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Floriane Pelon
Brigitte Bourachot
Yann Kieffer
Ilaria Magagna
Fanny Mermet-Meillon
Isabelle Bonnet
Ana Costa
Anne-Marie Givel
Youmna Attieh
Jorge Barbazan
Claire Bonneau
Laetitia Fuhrmann
Stéphanie Descroix
Danijela Vignjevic
Pascal Silberzan
Maria Carla Parrini
Anne Vincent-Salomon
Fatima Mechta-Grigoriou
Cancer-associated fibroblast heterogeneity in axillary lymph nodes drives metastases in breast cancer through complementary mechanisms
description Cancer associated fibroblasts are known to promote the progression of cancer. Here, the authors show that two particular subsets of cancer associated fibroblasts induce metastasis but work via distinct mechanisms including, chemokine signalling and Notch signalling.
format article
author Floriane Pelon
Brigitte Bourachot
Yann Kieffer
Ilaria Magagna
Fanny Mermet-Meillon
Isabelle Bonnet
Ana Costa
Anne-Marie Givel
Youmna Attieh
Jorge Barbazan
Claire Bonneau
Laetitia Fuhrmann
Stéphanie Descroix
Danijela Vignjevic
Pascal Silberzan
Maria Carla Parrini
Anne Vincent-Salomon
Fatima Mechta-Grigoriou
author_facet Floriane Pelon
Brigitte Bourachot
Yann Kieffer
Ilaria Magagna
Fanny Mermet-Meillon
Isabelle Bonnet
Ana Costa
Anne-Marie Givel
Youmna Attieh
Jorge Barbazan
Claire Bonneau
Laetitia Fuhrmann
Stéphanie Descroix
Danijela Vignjevic
Pascal Silberzan
Maria Carla Parrini
Anne Vincent-Salomon
Fatima Mechta-Grigoriou
author_sort Floriane Pelon
title Cancer-associated fibroblast heterogeneity in axillary lymph nodes drives metastases in breast cancer through complementary mechanisms
title_short Cancer-associated fibroblast heterogeneity in axillary lymph nodes drives metastases in breast cancer through complementary mechanisms
title_full Cancer-associated fibroblast heterogeneity in axillary lymph nodes drives metastases in breast cancer through complementary mechanisms
title_fullStr Cancer-associated fibroblast heterogeneity in axillary lymph nodes drives metastases in breast cancer through complementary mechanisms
title_full_unstemmed Cancer-associated fibroblast heterogeneity in axillary lymph nodes drives metastases in breast cancer through complementary mechanisms
title_sort cancer-associated fibroblast heterogeneity in axillary lymph nodes drives metastases in breast cancer through complementary mechanisms
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/cffe5431806244e5b3bdeb1e1726578f
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