Perirenal Adipose Tissue from Healthy Donor: Characteristics and Promise as Potential Therapeutic Cell Source

Perirenal adipose tissue, one of the fat masses surrounding the kidneys, can be obtained from healthy donors during a kidney transplant. Perirenal adipose tissue has only ever been known as a connective tissue to protect the kidneys and renal blood vessels from external physical stimulation. Yet, re...

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Autores principales:	Eun Hye Lee, So Young Chun, Jun Nyung Lee, Jae-Wook Chung, Bo Hyun Yoon, Hyun Tae Kim, Tae Gyun Kwon, Yun-Sok Ha, Bum Soo Kim
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	perirenal adipose tissue healthy donor brown adipocyte beige cell Medicine R
Acceso en línea:	https://doaj.org/article/d003519b48c24920942bb9c2e1227776
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spelling	oai:doaj.org-article:d003519b48c24920942bb9c2e12277762021-11-11T17:39:14ZPerirenal Adipose Tissue from Healthy Donor: Characteristics and Promise as Potential Therapeutic Cell Source10.3390/jcm102150242077-0383https://doaj.org/article/d003519b48c24920942bb9c2e12277762021-10-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/21/5024https://doaj.org/toc/2077-0383Perirenal adipose tissue, one of the fat masses surrounding the kidneys, can be obtained from healthy donors during a kidney transplant. Perirenal adipose tissue has only ever been known as a connective tissue to protect the kidneys and renal blood vessels from external physical stimulation. Yet, recently, as adipose tissue has begun to be considered an endocrine organ, and perirenal adipose tissue is now regarded to have a direct effect on metabolic diseases. The characteristics of perirenal adipose tissue from a healthy donor are that: (1) There are a large number of brown adipose cells (70–80% of the total), (2) Most of the brown adipose cells are inactive in the resting cell cycle, (3) Activating factors are constant low-temperature exposure, hormones, metastasis factors, and environmental factors, (4) Anatomically, a large number of brown adipose cells are distributed close to the adrenal glands, (5) Beige cells, produced by converting white adipocytes to brown-like adipocytes, are highly active, (6) Activated cells secrete BATokines, and (7) Energy consumption efficiency is high. Despite these advantages, all of the perirenal adipose tissue from a healthy donor is incinerated as medical waste. With a view to its use, this review discusses the brown adipocytes and beige cells in perirenal adipose tissue from a healthy donor, and proposes opportunities for their clinical application.Eun Hye LeeSo Young ChunJun Nyung LeeJae-Wook ChungBo Hyun YoonHyun Tae KimTae Gyun KwonYun-Sok HaBum Soo KimMDPI AGarticleperirenaladipose tissuehealthy donorbrown adipocytebeige cellMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5024, p 5024 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	perirenal adipose tissue healthy donor brown adipocyte beige cell Medicine R
spellingShingle	perirenal adipose tissue healthy donor brown adipocyte beige cell Medicine R Eun Hye Lee So Young Chun Jun Nyung Lee Jae-Wook Chung Bo Hyun Yoon Hyun Tae Kim Tae Gyun Kwon Yun-Sok Ha Bum Soo Kim Perirenal Adipose Tissue from Healthy Donor: Characteristics and Promise as Potential Therapeutic Cell Source
description	Perirenal adipose tissue, one of the fat masses surrounding the kidneys, can be obtained from healthy donors during a kidney transplant. Perirenal adipose tissue has only ever been known as a connective tissue to protect the kidneys and renal blood vessels from external physical stimulation. Yet, recently, as adipose tissue has begun to be considered an endocrine organ, and perirenal adipose tissue is now regarded to have a direct effect on metabolic diseases. The characteristics of perirenal adipose tissue from a healthy donor are that: (1) There are a large number of brown adipose cells (70–80% of the total), (2) Most of the brown adipose cells are inactive in the resting cell cycle, (3) Activating factors are constant low-temperature exposure, hormones, metastasis factors, and environmental factors, (4) Anatomically, a large number of brown adipose cells are distributed close to the adrenal glands, (5) Beige cells, produced by converting white adipocytes to brown-like adipocytes, are highly active, (6) Activated cells secrete BATokines, and (7) Energy consumption efficiency is high. Despite these advantages, all of the perirenal adipose tissue from a healthy donor is incinerated as medical waste. With a view to its use, this review discusses the brown adipocytes and beige cells in perirenal adipose tissue from a healthy donor, and proposes opportunities for their clinical application.
format	article
author	Eun Hye Lee So Young Chun Jun Nyung Lee Jae-Wook Chung Bo Hyun Yoon Hyun Tae Kim Tae Gyun Kwon Yun-Sok Ha Bum Soo Kim
author_facet	Eun Hye Lee So Young Chun Jun Nyung Lee Jae-Wook Chung Bo Hyun Yoon Hyun Tae Kim Tae Gyun Kwon Yun-Sok Ha Bum Soo Kim
author_sort	Eun Hye Lee
title	Perirenal Adipose Tissue from Healthy Donor: Characteristics and Promise as Potential Therapeutic Cell Source
title_short	Perirenal Adipose Tissue from Healthy Donor: Characteristics and Promise as Potential Therapeutic Cell Source
title_full	Perirenal Adipose Tissue from Healthy Donor: Characteristics and Promise as Potential Therapeutic Cell Source
title_fullStr	Perirenal Adipose Tissue from Healthy Donor: Characteristics and Promise as Potential Therapeutic Cell Source
title_full_unstemmed	Perirenal Adipose Tissue from Healthy Donor: Characteristics and Promise as Potential Therapeutic Cell Source
title_sort	perirenal adipose tissue from healthy donor: characteristics and promise as potential therapeutic cell source
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/d003519b48c24920942bb9c2e1227776
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Perirenal Adipose Tissue from Healthy Donor: Characteristics and Promise as Potential Therapeutic Cell Source

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