Prophylactic orthosteric inhibition of leukocyte integrin CD11b/CD18 prevents long-term fibrotic kidney failure in cynomolgus monkeys

Acute kidney injury can progress to chronic kidney disease. Here Dehnadiet al. develop a post-ischaemic chronic kidney disease model in cynomolgus monkeys and show that prophylactic inhibition of CD11b/CD18 leukocyte receptor via a monoclonal antibody inhibits progression of kidney disease and fibro...

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Autores principales:	Abbas Dehnadi, A. Benedict Cosimi, Rex Neal Smith, Xiangen Li, José L. Alonso, Terry K. Means, M. Amin Arnaout
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d0055b59431d4c87ad00b0f269919925
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spelling	oai:doaj.org-article:d0055b59431d4c87ad00b0f2699199252021-12-02T14:40:45ZProphylactic orthosteric inhibition of leukocyte integrin CD11b/CD18 prevents long-term fibrotic kidney failure in cynomolgus monkeys10.1038/ncomms138992041-1723https://doaj.org/article/d0055b59431d4c87ad00b0f2699199252017-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms13899https://doaj.org/toc/2041-1723Acute kidney injury can progress to chronic kidney disease. Here Dehnadiet al. develop a post-ischaemic chronic kidney disease model in cynomolgus monkeys and show that prophylactic inhibition of CD11b/CD18 leukocyte receptor via a monoclonal antibody inhibits progression of kidney disease and fibrosis.Abbas DehnadiA. Benedict CosimiRex Neal SmithXiangen LiJosé L. AlonsoTerry K. MeansM. Amin ArnaoutNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Abbas Dehnadi A. Benedict Cosimi Rex Neal Smith Xiangen Li José L. Alonso Terry K. Means M. Amin Arnaout Prophylactic orthosteric inhibition of leukocyte integrin CD11b/CD18 prevents long-term fibrotic kidney failure in cynomolgus monkeys
description	Acute kidney injury can progress to chronic kidney disease. Here Dehnadiet al. develop a post-ischaemic chronic kidney disease model in cynomolgus monkeys and show that prophylactic inhibition of CD11b/CD18 leukocyte receptor via a monoclonal antibody inhibits progression of kidney disease and fibrosis.
format	article
author	Abbas Dehnadi A. Benedict Cosimi Rex Neal Smith Xiangen Li José L. Alonso Terry K. Means M. Amin Arnaout
author_facet	Abbas Dehnadi A. Benedict Cosimi Rex Neal Smith Xiangen Li José L. Alonso Terry K. Means M. Amin Arnaout
author_sort	Abbas Dehnadi
title	Prophylactic orthosteric inhibition of leukocyte integrin CD11b/CD18 prevents long-term fibrotic kidney failure in cynomolgus monkeys
title_short	Prophylactic orthosteric inhibition of leukocyte integrin CD11b/CD18 prevents long-term fibrotic kidney failure in cynomolgus monkeys
title_full	Prophylactic orthosteric inhibition of leukocyte integrin CD11b/CD18 prevents long-term fibrotic kidney failure in cynomolgus monkeys
title_fullStr	Prophylactic orthosteric inhibition of leukocyte integrin CD11b/CD18 prevents long-term fibrotic kidney failure in cynomolgus monkeys
title_full_unstemmed	Prophylactic orthosteric inhibition of leukocyte integrin CD11b/CD18 prevents long-term fibrotic kidney failure in cynomolgus monkeys
title_sort	prophylactic orthosteric inhibition of leukocyte integrin cd11b/cd18 prevents long-term fibrotic kidney failure in cynomolgus monkeys
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/d0055b59431d4c87ad00b0f269919925
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Prophylactic orthosteric inhibition of leukocyte integrin CD11b/CD18 prevents long-term fibrotic kidney failure in cynomolgus monkeys

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