A potent neutralizing antibody with therapeutic potential against all four serotypes of dengue virus
Dengue: A single vaccine candidate for all strains An antibody-vaccine candidate has been discovered that neutralizes and confers protection against all four strains of dengue virus. Katja Fink, of the Singapore Immunology Network and Nanyang Technological University, Singapore, describes this as th...
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Nature Portfolio
2017
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oai:doaj.org-article:d00823a1151b41528cddd99e691c0ef62021-12-02T16:20:00ZA potent neutralizing antibody with therapeutic potential against all four serotypes of dengue virus10.1038/s41541-016-0003-32059-0105https://doaj.org/article/d00823a1151b41528cddd99e691c0ef62017-01-01T00:00:00Zhttps://doi.org/10.1038/s41541-016-0003-3https://doaj.org/toc/2059-0105Dengue: A single vaccine candidate for all strains An antibody-vaccine candidate has been discovered that neutralizes and confers protection against all four strains of dengue virus. Katja Fink, of the Singapore Immunology Network and Nanyang Technological University, Singapore, describes this as the first time a highly neutralizing antibody has shown efficacy against all four strains. Fink’s team, consisting of scientists from institutions across the country, tested the candidate (SIgN-3C-LALA) in both pre-exposure and post-exposure mouse models. The findings showed it reduced blood-virus levels, protected from lethal infection, and also offered improved safety—without compromising efficacy—the latter by way of intentional mutations to the antibody’s structure. As the global cost of dengue treatment is as high as 9 billion US$ per year, further study is needed to evaluate the suitability of the antibody candidate for the treatment of dengue in humans.Meihui XuRoland ZuestSumathy VelumaniFarhana TukijanYing Xiu TohRamapraba AppannaErn Yu TanDaniela CernyPaul MacAryCheng-I WangKatja FinkNature PortfolioarticleImmunologic diseases. AllergyRC581-607Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Vaccines, Vol 2, Iss 1, Pp 1-10 (2017) |
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DOAJ |
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EN |
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Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 |
| spellingShingle |
Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Meihui Xu Roland Zuest Sumathy Velumani Farhana Tukijan Ying Xiu Toh Ramapraba Appanna Ern Yu Tan Daniela Cerny Paul MacAry Cheng-I Wang Katja Fink A potent neutralizing antibody with therapeutic potential against all four serotypes of dengue virus |
| description |
Dengue: A single vaccine candidate for all strains An antibody-vaccine candidate has been discovered that neutralizes and confers protection against all four strains of dengue virus. Katja Fink, of the Singapore Immunology Network and Nanyang Technological University, Singapore, describes this as the first time a highly neutralizing antibody has shown efficacy against all four strains. Fink’s team, consisting of scientists from institutions across the country, tested the candidate (SIgN-3C-LALA) in both pre-exposure and post-exposure mouse models. The findings showed it reduced blood-virus levels, protected from lethal infection, and also offered improved safety—without compromising efficacy—the latter by way of intentional mutations to the antibody’s structure. As the global cost of dengue treatment is as high as 9 billion US$ per year, further study is needed to evaluate the suitability of the antibody candidate for the treatment of dengue in humans. |
| format |
article |
| author |
Meihui Xu Roland Zuest Sumathy Velumani Farhana Tukijan Ying Xiu Toh Ramapraba Appanna Ern Yu Tan Daniela Cerny Paul MacAry Cheng-I Wang Katja Fink |
| author_facet |
Meihui Xu Roland Zuest Sumathy Velumani Farhana Tukijan Ying Xiu Toh Ramapraba Appanna Ern Yu Tan Daniela Cerny Paul MacAry Cheng-I Wang Katja Fink |
| author_sort |
Meihui Xu |
| title |
A potent neutralizing antibody with therapeutic potential against all four serotypes of dengue virus |
| title_short |
A potent neutralizing antibody with therapeutic potential against all four serotypes of dengue virus |
| title_full |
A potent neutralizing antibody with therapeutic potential against all four serotypes of dengue virus |
| title_fullStr |
A potent neutralizing antibody with therapeutic potential against all four serotypes of dengue virus |
| title_full_unstemmed |
A potent neutralizing antibody with therapeutic potential against all four serotypes of dengue virus |
| title_sort |
potent neutralizing antibody with therapeutic potential against all four serotypes of dengue virus |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/d00823a1151b41528cddd99e691c0ef6 |
| work_keys_str_mv |
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| _version_ |
1718384200615198720 |