Clinical improvement following vitamin D3 supplementation in children with chronic tic disorders

Hong-Hua Li,1 Zhi-Da Xu,1,2 Bing Wang,1 Jun-Yan Feng,1 Han-Yu Dong,1 Fei-Yong Jia1,31Department of Developmental and Behavioral Pediatrics, The First Hospital of Jilin University, Changchun, Jilin 130021, People’s Republic of China; 2Department of Psychiatry, University Medical Center Utre...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Li HH, Xu ZD, Wang B, Feng JY, Dong HY, Jia FY
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Vitamin D Chronic tic disorders 25(OH)D Dopamine Child Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/d00e80ef56b5484bb8c7664d7a73124c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d00e80ef56b5484bb8c7664d7a73124c
record_format	dspace
spelling	oai:doaj.org-article:d00e80ef56b5484bb8c7664d7a73124c2021-12-02T11:32:46ZClinical improvement following vitamin D3 supplementation in children with chronic tic disorders1178-2021https://doaj.org/article/d00e80ef56b5484bb8c7664d7a73124c2019-08-01T00:00:00Zhttps://www.dovepress.com/clinical-improvement-following-vitamin-d3-supplementation-in-children--peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Hong-Hua Li,1 Zhi-Da Xu,1,2 Bing Wang,1 Jun-Yan Feng,1 Han-Yu Dong,1 Fei-Yong Jia1,31Department of Developmental and Behavioral Pediatrics, The First Hospital of Jilin University, Changchun, Jilin 130021, People’s Republic of China; 2Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands; 3Neurological Research Center of the First Hospital of Jilin University, Changchun, People’s Republic of ChinaCorrespondence: Fei-Yong JiaDepartment of Developmental and Behavioral Pediatrics, The First Hospital of Jilin University, Changchun, Jilin 130021, People’s Republic of ChinaTel +86 04 318 878 3846Email erkekangfujia@163.comPurpose: Vitamin D deficiency has been found in children with chronic tic disorders (CTDs). Our previous data showed that serum 25-hydroxyvitamin D [25(OH)D] level in children with CTDs was lower than that of the healthy controls and lower serum 25(OH)D level was associated with increased severity of the tic disorder. Thus, we intend to further verify this phenomenon and examine the effect of vitamin D3 on CTDs.Patients and methods: In total, 120 children with CTDs and 140 normal controls were enrolled in this study, with 36/120 of those in the CTD group receiving vitamin D3 treatment for 3 months. The Yale Global Tic Severity Scale (YGTSS) and Clinical Global Impression of Severity of Illness (CGI-SI) were, respectively, used to evaluate the tic severity. High-performance liquid chromatography and tandem mass spectrometry were used to measure serum 25(OH)D level.Results: Those children with CTDs exhibited significantly lower 25(OH)D levels than did healthy controls, and these reduced 25(OH)D levels were linked to increasing severity of tic symptoms. After treatment with supplemental vitamin D3, serum 25(OH)D level and scores of YGTSS total, motor tics, phonic tics, total tic, impairment, and CGI-SI improved significantly in children with CTDs without any adverse reactions.Conclusion: Supplementation vitamin D3, given its low cost and excellent safety, may be an effective means of improving symptoms in certain children with CTDs.Keywords: vitamin D, chronic tic disorders, 25(OH)D, dopamine, childLi HHXu ZDWang BFeng JYDong HYJia FYDove Medical PressarticleVitamin DChronic tic disorders25(OH)DDopamineChildNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 15, Pp 2443-2450 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Vitamin D Chronic tic disorders 25(OH)D Dopamine Child Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Vitamin D Chronic tic disorders 25(OH)D Dopamine Child Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Li HH Xu ZD Wang B Feng JY Dong HY Jia FY Clinical improvement following vitamin D3 supplementation in children with chronic tic disorders
description	Hong-Hua Li,1 Zhi-Da Xu,1,2 Bing Wang,1 Jun-Yan Feng,1 Han-Yu Dong,1 Fei-Yong Jia1,31Department of Developmental and Behavioral Pediatrics, The First Hospital of Jilin University, Changchun, Jilin 130021, People’s Republic of China; 2Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands; 3Neurological Research Center of the First Hospital of Jilin University, Changchun, People’s Republic of ChinaCorrespondence: Fei-Yong JiaDepartment of Developmental and Behavioral Pediatrics, The First Hospital of Jilin University, Changchun, Jilin 130021, People’s Republic of ChinaTel +86 04 318 878 3846Email erkekangfujia@163.comPurpose: Vitamin D deficiency has been found in children with chronic tic disorders (CTDs). Our previous data showed that serum 25-hydroxyvitamin D [25(OH)D] level in children with CTDs was lower than that of the healthy controls and lower serum 25(OH)D level was associated with increased severity of the tic disorder. Thus, we intend to further verify this phenomenon and examine the effect of vitamin D3 on CTDs.Patients and methods: In total, 120 children with CTDs and 140 normal controls were enrolled in this study, with 36/120 of those in the CTD group receiving vitamin D3 treatment for 3 months. The Yale Global Tic Severity Scale (YGTSS) and Clinical Global Impression of Severity of Illness (CGI-SI) were, respectively, used to evaluate the tic severity. High-performance liquid chromatography and tandem mass spectrometry were used to measure serum 25(OH)D level.Results: Those children with CTDs exhibited significantly lower 25(OH)D levels than did healthy controls, and these reduced 25(OH)D levels were linked to increasing severity of tic symptoms. After treatment with supplemental vitamin D3, serum 25(OH)D level and scores of YGTSS total, motor tics, phonic tics, total tic, impairment, and CGI-SI improved significantly in children with CTDs without any adverse reactions.Conclusion: Supplementation vitamin D3, given its low cost and excellent safety, may be an effective means of improving symptoms in certain children with CTDs.Keywords: vitamin D, chronic tic disorders, 25(OH)D, dopamine, child
format	article
author	Li HH Xu ZD Wang B Feng JY Dong HY Jia FY
author_facet	Li HH Xu ZD Wang B Feng JY Dong HY Jia FY
author_sort	Li HH
title	Clinical improvement following vitamin D3 supplementation in children with chronic tic disorders
title_short	Clinical improvement following vitamin D3 supplementation in children with chronic tic disorders
title_full	Clinical improvement following vitamin D3 supplementation in children with chronic tic disorders
title_fullStr	Clinical improvement following vitamin D3 supplementation in children with chronic tic disorders
title_full_unstemmed	Clinical improvement following vitamin D3 supplementation in children with chronic tic disorders
title_sort	clinical improvement following vitamin d3 supplementation in children with chronic tic disorders
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/d00e80ef56b5484bb8c7664d7a73124c
work_keys_str_mv	AT lihh clinicalimprovementfollowingvitamind3supplementationinchildrenwithchronicticdisorders AT xuzd clinicalimprovementfollowingvitamind3supplementationinchildrenwithchronicticdisorders AT wangb clinicalimprovementfollowingvitamind3supplementationinchildrenwithchronicticdisorders AT fengjy clinicalimprovementfollowingvitamind3supplementationinchildrenwithchronicticdisorders AT donghy clinicalimprovementfollowingvitamind3supplementationinchildrenwithchronicticdisorders AT jiafy clinicalimprovementfollowingvitamind3supplementationinchildrenwithchronicticdisorders
_version_	1718395848065286144

Clinical improvement following vitamin D3 supplementation in children with chronic tic disorders

Ejemplares similares