Dual-responsive dithio-polydopamine coated porous CeO2 nanorods for targeted and synergistic drug delivery

Ying Zhang,1,* Xiaowen Wu,1,* Chenxi Hou,1 Kun Shang,1 Kui Yang,1 Zhimin Tian,2 Zhichao Pei,1 Yongquan Qu,2 Yuxin Pei1 1Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry and Pharmacy, Northwest A&F University, Yangling, Shaanxi, People’s R...

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Autores principales:	Zhang Y, Wu X, Hou C, Shang K, Yang K, Tian ZM, Pei Z, Qu Y, Pei Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	biodegradable polydopamine cerium oxide nanoparticales dual-responsiveness targeted drug delivery synergistic anticancer Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/d00e9cbc3b9a46e9b743b41762fd9f51
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spelling	oai:doaj.org-article:d00e9cbc3b9a46e9b743b41762fd9f512021-12-02T05:57:03ZDual-responsive dithio-polydopamine coated porous CeO2 nanorods for targeted and synergistic drug delivery1178-2013https://doaj.org/article/d00e9cbc3b9a46e9b743b41762fd9f512018-04-01T00:00:00Zhttps://www.dovepress.com/dual-responsive-dithio-polydopamine-coated-porous-ceo2-nanorods-for-ta-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Ying Zhang,1,* Xiaowen Wu,1,* Chenxi Hou,1 Kun Shang,1 Kui Yang,1 Zhimin Tian,2 Zhichao Pei,1 Yongquan Qu,2 Yuxin Pei1 1Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry and Pharmacy, Northwest A&F University, Yangling, Shaanxi, People’s Republic of China; 2Center for Applied Chemical Research, Frontier Institute of Science and Technology, Xi’an Jiaotong University, Xi’an, People’s Republic of China *These authors contributed equally to this work Objective: The aim was to produce the first report of assembling degradable stimuli-responsive dithio-polydopamine coating with a cancer target unit for synergistic and targeted drug delivery. Methods: A multifunctional drug delivery system was constructed by coating a dual-responsive dithio-polydopamine (PDS) on porous CeO2 nanorods and subsequent conjugation of lactose derivative, where the PDS was formed by self-polymerization of dithio-dopamine (DOPASS). Results: The multifunctional drug delivery system displayed excellent cancer targeted ability resulting from the conjugation of lactose derivative, which could specifically recognize the overexpressed asialoglycoprotein receptors on the surface of HepG2 cells. It also showed a dual-responsive property of glutathione and pH, achieving controllable drug release from the cleavage of disulfide bond and subsequent degradation of PDS in cancer cells. Moreover, the degradation of PDS led to the exposure of CeO2 nanorods, which has a synergistic anticancer effect due to its cytotoxicity to cancer cells. Conclusion: This work presents a good example of a rational design towards synergistic and targeted DDS for cancer chemotherapies. Keywords: degradable polydopamine, cerium oxide nanoparticles, dual-responsiveness, targeted drug delivery, synergistic anticancerZhang YWu XHou CShang KYang KTian ZMPei ZQu YPei YDove Medical Pressarticlebiodegradable polydopaminecerium oxide nanoparticalesdual-responsivenesstargeted drug deliverysynergistic anticancerMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 2161-2173 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	biodegradable polydopamine cerium oxide nanoparticales dual-responsiveness targeted drug delivery synergistic anticancer Medicine (General) R5-920
spellingShingle	biodegradable polydopamine cerium oxide nanoparticales dual-responsiveness targeted drug delivery synergistic anticancer Medicine (General) R5-920 Zhang Y Wu X Hou C Shang K Yang K Tian ZM Pei Z Qu Y Pei Y Dual-responsive dithio-polydopamine coated porous CeO2 nanorods for targeted and synergistic drug delivery
description	Ying Zhang,1,* Xiaowen Wu,1,* Chenxi Hou,1 Kun Shang,1 Kui Yang,1 Zhimin Tian,2 Zhichao Pei,1 Yongquan Qu,2 Yuxin Pei1 1Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry and Pharmacy, Northwest A&F University, Yangling, Shaanxi, People’s Republic of China; 2Center for Applied Chemical Research, Frontier Institute of Science and Technology, Xi’an Jiaotong University, Xi’an, People’s Republic of China *These authors contributed equally to this work Objective: The aim was to produce the first report of assembling degradable stimuli-responsive dithio-polydopamine coating with a cancer target unit for synergistic and targeted drug delivery. Methods: A multifunctional drug delivery system was constructed by coating a dual-responsive dithio-polydopamine (PDS) on porous CeO2 nanorods and subsequent conjugation of lactose derivative, where the PDS was formed by self-polymerization of dithio-dopamine (DOPASS). Results: The multifunctional drug delivery system displayed excellent cancer targeted ability resulting from the conjugation of lactose derivative, which could specifically recognize the overexpressed asialoglycoprotein receptors on the surface of HepG2 cells. It also showed a dual-responsive property of glutathione and pH, achieving controllable drug release from the cleavage of disulfide bond and subsequent degradation of PDS in cancer cells. Moreover, the degradation of PDS led to the exposure of CeO2 nanorods, which has a synergistic anticancer effect due to its cytotoxicity to cancer cells. Conclusion: This work presents a good example of a rational design towards synergistic and targeted DDS for cancer chemotherapies. Keywords: degradable polydopamine, cerium oxide nanoparticles, dual-responsiveness, targeted drug delivery, synergistic anticancer
format	article
author	Zhang Y Wu X Hou C Shang K Yang K Tian ZM Pei Z Qu Y Pei Y
author_facet	Zhang Y Wu X Hou C Shang K Yang K Tian ZM Pei Z Qu Y Pei Y
author_sort	Zhang Y
title	Dual-responsive dithio-polydopamine coated porous CeO2 nanorods for targeted and synergistic drug delivery
title_short	Dual-responsive dithio-polydopamine coated porous CeO2 nanorods for targeted and synergistic drug delivery
title_full	Dual-responsive dithio-polydopamine coated porous CeO2 nanorods for targeted and synergistic drug delivery
title_fullStr	Dual-responsive dithio-polydopamine coated porous CeO2 nanorods for targeted and synergistic drug delivery
title_full_unstemmed	Dual-responsive dithio-polydopamine coated porous CeO2 nanorods for targeted and synergistic drug delivery
title_sort	dual-responsive dithio-polydopamine coated porous ceo2 nanorods for targeted and synergistic drug delivery
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/d00e9cbc3b9a46e9b743b41762fd9f51
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Dual-responsive dithio-polydopamine coated porous CeO2 nanorods for targeted and synergistic drug delivery

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