Generation of mice with longer and better preserved telomeres in the absence of genetic manipulations

Telomere shortening has been linked to some aspects of organismal ageing. Here the authors create chimaeric mice that contain a mix of cells with normal or unnaturally long telomeres, and show chimaeric mice are protected from some forms of ageing-associated cellular damage and have accelerated woun...

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Autores principales:	Elisa Varela, Miguel A. Muñoz-Lorente, Agueda M. Tejera, Sagrario Ortega, Maria A. Blasco
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d0106904dff5400da6c8a5952d1b3cbb
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spelling	oai:doaj.org-article:d0106904dff5400da6c8a5952d1b3cbb2021-12-02T17:31:32ZGeneration of mice with longer and better preserved telomeres in the absence of genetic manipulations10.1038/ncomms117392041-1723https://doaj.org/article/d0106904dff5400da6c8a5952d1b3cbb2016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms11739https://doaj.org/toc/2041-1723Telomere shortening has been linked to some aspects of organismal ageing. Here the authors create chimaeric mice that contain a mix of cells with normal or unnaturally long telomeres, and show chimaeric mice are protected from some forms of ageing-associated cellular damage and have accelerated wound-healing.Elisa VarelaMiguel A. Muñoz-LorenteAgueda M. TejeraSagrario OrtegaMaria A. BlascoNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Elisa Varela Miguel A. Muñoz-Lorente Agueda M. Tejera Sagrario Ortega Maria A. Blasco Generation of mice with longer and better preserved telomeres in the absence of genetic manipulations
description	Telomere shortening has been linked to some aspects of organismal ageing. Here the authors create chimaeric mice that contain a mix of cells with normal or unnaturally long telomeres, and show chimaeric mice are protected from some forms of ageing-associated cellular damage and have accelerated wound-healing.
format	article
author	Elisa Varela Miguel A. Muñoz-Lorente Agueda M. Tejera Sagrario Ortega Maria A. Blasco
author_facet	Elisa Varela Miguel A. Muñoz-Lorente Agueda M. Tejera Sagrario Ortega Maria A. Blasco
author_sort	Elisa Varela
title	Generation of mice with longer and better preserved telomeres in the absence of genetic manipulations
title_short	Generation of mice with longer and better preserved telomeres in the absence of genetic manipulations
title_full	Generation of mice with longer and better preserved telomeres in the absence of genetic manipulations
title_fullStr	Generation of mice with longer and better preserved telomeres in the absence of genetic manipulations
title_full_unstemmed	Generation of mice with longer and better preserved telomeres in the absence of genetic manipulations
title_sort	generation of mice with longer and better preserved telomeres in the absence of genetic manipulations
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/d0106904dff5400da6c8a5952d1b3cbb
work_keys_str_mv	AT elisavarela generationofmicewithlongerandbetterpreservedtelomeresintheabsenceofgeneticmanipulations AT miguelamunozlorente generationofmicewithlongerandbetterpreservedtelomeresintheabsenceofgeneticmanipulations AT aguedamtejera generationofmicewithlongerandbetterpreservedtelomeresintheabsenceofgeneticmanipulations AT sagrarioortega generationofmicewithlongerandbetterpreservedtelomeresintheabsenceofgeneticmanipulations AT mariaablasco generationofmicewithlongerandbetterpreservedtelomeresintheabsenceofgeneticmanipulations
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Generation of mice with longer and better preserved telomeres in the absence of genetic manipulations

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