Diverse Roles and Therapeutic Potentials of Circular RNAs in Urological Cancers

Circular RNAs (circRNAs) are a novel class of noncoding RNAs, which are mainly formed as a loop structure at the exons caused by noncanonical splicing; they are much more stable than linear transcripts; recent reports have suggested that the dysregulation of circRNAs is associated with the occurrenc...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Song Wang, Yufan Ying, Xueyou Ma, Weiyu Wang, Xiao Wang, Liping Xie
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	circular RNAs urological cancers biomarker therapy targets mechanism Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/d0108f7d5cff4a0db938cdf944510380
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d0108f7d5cff4a0db938cdf944510380
record_format	dspace
spelling	oai:doaj.org-article:d0108f7d5cff4a0db938cdf9445103802021-11-19T06:47:45ZDiverse Roles and Therapeutic Potentials of Circular RNAs in Urological Cancers2296-889X10.3389/fmolb.2021.761698https://doaj.org/article/d0108f7d5cff4a0db938cdf9445103802021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmolb.2021.761698/fullhttps://doaj.org/toc/2296-889XCircular RNAs (circRNAs) are a novel class of noncoding RNAs, which are mainly formed as a loop structure at the exons caused by noncanonical splicing; they are much more stable than linear transcripts; recent reports have suggested that the dysregulation of circRNAs is associated with the occurrence and development of diseases, especially various human malignancies. Emerging evidence demonstrated that a large number of circRNAs play a vital role in a series of biological processes such as tumor cell proliferation, migration, drug resistance, and immune escape. Additionally, circRNAs were also reported to be potential prognostic and diagnostic biomarkers in cancers. In this work, we systematically summarize the biogenesis and characteristics of circRNAs, paying special attention to potential mechanisms and clinical applications of circRNAs in urological cancers, which may help develop potential therapy targets for urological cancers in the future.Song WangYufan YingXueyou MaWeiyu WangXiao WangLiping XieFrontiers Media S.A.articlecircular RNAsurological cancersbiomarkertherapy targetsmechanismBiology (General)QH301-705.5ENFrontiers in Molecular Biosciences, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	circular RNAs urological cancers biomarker therapy targets mechanism Biology (General) QH301-705.5
spellingShingle	circular RNAs urological cancers biomarker therapy targets mechanism Biology (General) QH301-705.5 Song Wang Yufan Ying Xueyou Ma Weiyu Wang Xiao Wang Liping Xie Diverse Roles and Therapeutic Potentials of Circular RNAs in Urological Cancers
description	Circular RNAs (circRNAs) are a novel class of noncoding RNAs, which are mainly formed as a loop structure at the exons caused by noncanonical splicing; they are much more stable than linear transcripts; recent reports have suggested that the dysregulation of circRNAs is associated with the occurrence and development of diseases, especially various human malignancies. Emerging evidence demonstrated that a large number of circRNAs play a vital role in a series of biological processes such as tumor cell proliferation, migration, drug resistance, and immune escape. Additionally, circRNAs were also reported to be potential prognostic and diagnostic biomarkers in cancers. In this work, we systematically summarize the biogenesis and characteristics of circRNAs, paying special attention to potential mechanisms and clinical applications of circRNAs in urological cancers, which may help develop potential therapy targets for urological cancers in the future.
format	article
author	Song Wang Yufan Ying Xueyou Ma Weiyu Wang Xiao Wang Liping Xie
author_facet	Song Wang Yufan Ying Xueyou Ma Weiyu Wang Xiao Wang Liping Xie
author_sort	Song Wang
title	Diverse Roles and Therapeutic Potentials of Circular RNAs in Urological Cancers
title_short	Diverse Roles and Therapeutic Potentials of Circular RNAs in Urological Cancers
title_full	Diverse Roles and Therapeutic Potentials of Circular RNAs in Urological Cancers
title_fullStr	Diverse Roles and Therapeutic Potentials of Circular RNAs in Urological Cancers
title_full_unstemmed	Diverse Roles and Therapeutic Potentials of Circular RNAs in Urological Cancers
title_sort	diverse roles and therapeutic potentials of circular rnas in urological cancers
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/d0108f7d5cff4a0db938cdf944510380
work_keys_str_mv	AT songwang diverserolesandtherapeuticpotentialsofcircularrnasinurologicalcancers AT yufanying diverserolesandtherapeuticpotentialsofcircularrnasinurologicalcancers AT xueyouma diverserolesandtherapeuticpotentialsofcircularrnasinurologicalcancers AT weiyuwang diverserolesandtherapeuticpotentialsofcircularrnasinurologicalcancers AT xiaowang diverserolesandtherapeuticpotentialsofcircularrnasinurologicalcancers AT lipingxie diverserolesandtherapeuticpotentialsofcircularrnasinurologicalcancers
_version_	1718420342705225728

Diverse Roles and Therapeutic Potentials of Circular RNAs in Urological Cancers

Ejemplares similares