ABO and Rhesus Blood Groups in Acute Puumala Hantavirus Infection

Puumala hantavirus (PUUV) causes hemorrhagic fever with renal syndrome. We aimed to evaluate whether ABO and rhesus blood groups associate with the susceptibility or the severity of PUUV infection. We analyzed blood groups in 289 adult patients treated in Tampere University hospital due to PUUV infe...

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Autores principales:	Johanna Tietäväinen, Outi Laine, Satu Mäkelä, Heini Huhtala, Ilkka Pörsti, Antti Vaheri, Jukka Mustonen
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	Puumala hantavirus ABO blood groups rhesus blood groups capillary leakage AKI blood pressure Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/d0135eafa39a4ce982138a2866fae52e
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spelling	oai:doaj.org-article:d0135eafa39a4ce982138a2866fae52e2021-11-25T19:13:58ZABO and Rhesus Blood Groups in Acute Puumala Hantavirus Infection10.3390/v131122711999-4915https://doaj.org/article/d0135eafa39a4ce982138a2866fae52e2021-11-01T00:00:00Zhttps://www.mdpi.com/1999-4915/13/11/2271https://doaj.org/toc/1999-4915Puumala hantavirus (PUUV) causes hemorrhagic fever with renal syndrome. We aimed to evaluate whether ABO and rhesus blood groups associate with the susceptibility or the severity of PUUV infection. We analyzed blood groups in 289 adult patients treated in Tampere University hospital due to PUUV infection during the years 1982–2017. Patients’ blood group distribution was compared to that of healthy, voluntary blood donors living in the Tampere University Hospital responsibility area (<i>n</i> = 21,833). The severity of PUUV infection, as judged by the severity of acute kidney injury (AKI), thrombocytopenia, inflammation, capillary leakage, and the length of hospital care, was analyzed across the groups. The ABO and rhesus blood group distributions did not differ between the patients and blood donors. Patients with non-O blood groups had lower systolic blood pressure compared to patients with blood group O, but there was no difference in other markers of capillary leakage or in the severity of AKI. Minor deviations in the number of platelets and leukocytes were detected between the O and non-O blood groups. To conclude, patients with blood group O may be less susceptible to hypotension, but otherwise blood groups have no major influences on disease susceptibility or severity during acute PUUV infection.Johanna TietäväinenOuti LaineSatu MäkeläHeini HuhtalaIlkka PörstiAntti VaheriJukka MustonenMDPI AGarticlePuumala hantavirusABO blood groupsrhesus blood groupscapillary leakageAKIblood pressureMicrobiologyQR1-502ENViruses, Vol 13, Iss 2271, p 2271 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Puumala hantavirus ABO blood groups rhesus blood groups capillary leakage AKI blood pressure Microbiology QR1-502
spellingShingle	Puumala hantavirus ABO blood groups rhesus blood groups capillary leakage AKI blood pressure Microbiology QR1-502 Johanna Tietäväinen Outi Laine Satu Mäkelä Heini Huhtala Ilkka Pörsti Antti Vaheri Jukka Mustonen ABO and Rhesus Blood Groups in Acute Puumala Hantavirus Infection
description	Puumala hantavirus (PUUV) causes hemorrhagic fever with renal syndrome. We aimed to evaluate whether ABO and rhesus blood groups associate with the susceptibility or the severity of PUUV infection. We analyzed blood groups in 289 adult patients treated in Tampere University hospital due to PUUV infection during the years 1982–2017. Patients’ blood group distribution was compared to that of healthy, voluntary blood donors living in the Tampere University Hospital responsibility area (<i>n</i> = 21,833). The severity of PUUV infection, as judged by the severity of acute kidney injury (AKI), thrombocytopenia, inflammation, capillary leakage, and the length of hospital care, was analyzed across the groups. The ABO and rhesus blood group distributions did not differ between the patients and blood donors. Patients with non-O blood groups had lower systolic blood pressure compared to patients with blood group O, but there was no difference in other markers of capillary leakage or in the severity of AKI. Minor deviations in the number of platelets and leukocytes were detected between the O and non-O blood groups. To conclude, patients with blood group O may be less susceptible to hypotension, but otherwise blood groups have no major influences on disease susceptibility or severity during acute PUUV infection.
format	article
author	Johanna Tietäväinen Outi Laine Satu Mäkelä Heini Huhtala Ilkka Pörsti Antti Vaheri Jukka Mustonen
author_facet	Johanna Tietäväinen Outi Laine Satu Mäkelä Heini Huhtala Ilkka Pörsti Antti Vaheri Jukka Mustonen
author_sort	Johanna Tietäväinen
title	ABO and Rhesus Blood Groups in Acute Puumala Hantavirus Infection
title_short	ABO and Rhesus Blood Groups in Acute Puumala Hantavirus Infection
title_full	ABO and Rhesus Blood Groups in Acute Puumala Hantavirus Infection
title_fullStr	ABO and Rhesus Blood Groups in Acute Puumala Hantavirus Infection
title_full_unstemmed	ABO and Rhesus Blood Groups in Acute Puumala Hantavirus Infection
title_sort	abo and rhesus blood groups in acute puumala hantavirus infection
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/d0135eafa39a4ce982138a2866fae52e
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ABO and Rhesus Blood Groups in Acute Puumala Hantavirus Infection

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