Does 18F-FDG positron emission tomography-computed tomography have a role in initial staging of hepatocellular carcinoma?

<h4>Background and aim</h4>The utility of fluorine-18 fluorodeoxyglucose ((18)F-FDG) positron emission tomography-computed tomography (PET/CT) in initial staging of hepatocellular carcinoma (HCC) has yet to be fully explored. We assessed the usefulness of (18)F-FDG PET/CT in initial stag...

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Autores principales:	Yuri Cho, Dong Hyeon Lee, Yun Bin Lee, Minjong Lee, Jeong-Ju Yoo, Won-Mook Choi, Young Youn Cho, Jin Chul Paeng, Keon Wook Kang, June-Key Chung, Su Jong Yu, Jeong-Hoon Lee, Jung-Hwan Yoon, Hyo-Suk Lee, Yoon Jun Kim
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d013e47e5fe84c44b40ac1efbc0ad025
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spelling	oai:doaj.org-article:d013e47e5fe84c44b40ac1efbc0ad0252021-11-25T06:03:17ZDoes 18F-FDG positron emission tomography-computed tomography have a role in initial staging of hepatocellular carcinoma?1932-620310.1371/journal.pone.0105679https://doaj.org/article/d013e47e5fe84c44b40ac1efbc0ad0252014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25153834/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background and aim</h4>The utility of fluorine-18 fluorodeoxyglucose ((18)F-FDG) positron emission tomography-computed tomography (PET/CT) in initial staging of hepatocellular carcinoma (HCC) has yet to be fully explored. We assessed the usefulness of (18)F-FDG PET/CT in initial staging of HCC.<h4>Methods</h4>A total of 457 consecutive patients initially diagnosed with HCC at Seoul National University Hospital between 2006 and 2012 were evaluated retrospectively to assess the impact of (18)F-FDG PET/CT on staging and compliancy with Milan criteria, relative to dynamic CT of liver and chest x-ray.<h4>Results</h4>Seven among the 457 patients studied showed a shift in Barcelona Clinic Liver Cancer [BCLC] stage (A → C: 6 patients; B → C: 1 patient) and 5 patients who had originally met Milan criteria no longer qualified. (18)F-FDG PET/CT had value in initial staging of early (stage A) or intermediate (stage B) HCC, as determined by dynamic CT of liver and BCLC or AJCC classifications, whereas BCLC stage 0 and stage C tumors were unchanged (P<0.001). (18)F-FDG PET/CT disclosed additional metastases in patients with American Joint Committee on Cancer [AJCC] T2 (2.7%), T3a (5.3%), and T3b (4.8%) classifications.<h4>Conclusions</h4>In initial staging of HCC, (18)F-FDG PET/CT provided additional information, impacting the patients with BCLC (stages A and B) and AJCC (T2 and T3) classifications. Its use might be thus appropriate for these patient subsets, especially if hepatic resection or liver transplantation is planned.Yuri ChoDong Hyeon LeeYun Bin LeeMinjong LeeJeong-Ju YooWon-Mook ChoiYoung Youn ChoJin Chul PaengKeon Wook KangJune-Key ChungSu Jong YuJeong-Hoon LeeJung-Hwan YoonHyo-Suk LeeYoon Jun KimPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 8, p e105679 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yuri Cho Dong Hyeon Lee Yun Bin Lee Minjong Lee Jeong-Ju Yoo Won-Mook Choi Young Youn Cho Jin Chul Paeng Keon Wook Kang June-Key Chung Su Jong Yu Jeong-Hoon Lee Jung-Hwan Yoon Hyo-Suk Lee Yoon Jun Kim Does 18F-FDG positron emission tomography-computed tomography have a role in initial staging of hepatocellular carcinoma?
description	<h4>Background and aim</h4>The utility of fluorine-18 fluorodeoxyglucose ((18)F-FDG) positron emission tomography-computed tomography (PET/CT) in initial staging of hepatocellular carcinoma (HCC) has yet to be fully explored. We assessed the usefulness of (18)F-FDG PET/CT in initial staging of HCC.<h4>Methods</h4>A total of 457 consecutive patients initially diagnosed with HCC at Seoul National University Hospital between 2006 and 2012 were evaluated retrospectively to assess the impact of (18)F-FDG PET/CT on staging and compliancy with Milan criteria, relative to dynamic CT of liver and chest x-ray.<h4>Results</h4>Seven among the 457 patients studied showed a shift in Barcelona Clinic Liver Cancer [BCLC] stage (A → C: 6 patients; B → C: 1 patient) and 5 patients who had originally met Milan criteria no longer qualified. (18)F-FDG PET/CT had value in initial staging of early (stage A) or intermediate (stage B) HCC, as determined by dynamic CT of liver and BCLC or AJCC classifications, whereas BCLC stage 0 and stage C tumors were unchanged (P<0.001). (18)F-FDG PET/CT disclosed additional metastases in patients with American Joint Committee on Cancer [AJCC] T2 (2.7%), T3a (5.3%), and T3b (4.8%) classifications.<h4>Conclusions</h4>In initial staging of HCC, (18)F-FDG PET/CT provided additional information, impacting the patients with BCLC (stages A and B) and AJCC (T2 and T3) classifications. Its use might be thus appropriate for these patient subsets, especially if hepatic resection or liver transplantation is planned.
format	article
author	Yuri Cho Dong Hyeon Lee Yun Bin Lee Minjong Lee Jeong-Ju Yoo Won-Mook Choi Young Youn Cho Jin Chul Paeng Keon Wook Kang June-Key Chung Su Jong Yu Jeong-Hoon Lee Jung-Hwan Yoon Hyo-Suk Lee Yoon Jun Kim
author_facet	Yuri Cho Dong Hyeon Lee Yun Bin Lee Minjong Lee Jeong-Ju Yoo Won-Mook Choi Young Youn Cho Jin Chul Paeng Keon Wook Kang June-Key Chung Su Jong Yu Jeong-Hoon Lee Jung-Hwan Yoon Hyo-Suk Lee Yoon Jun Kim
author_sort	Yuri Cho
title	Does 18F-FDG positron emission tomography-computed tomography have a role in initial staging of hepatocellular carcinoma?
title_short	Does 18F-FDG positron emission tomography-computed tomography have a role in initial staging of hepatocellular carcinoma?
title_full	Does 18F-FDG positron emission tomography-computed tomography have a role in initial staging of hepatocellular carcinoma?
title_fullStr	Does 18F-FDG positron emission tomography-computed tomography have a role in initial staging of hepatocellular carcinoma?
title_full_unstemmed	Does 18F-FDG positron emission tomography-computed tomography have a role in initial staging of hepatocellular carcinoma?
title_sort	does 18f-fdg positron emission tomography-computed tomography have a role in initial staging of hepatocellular carcinoma?
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/d013e47e5fe84c44b40ac1efbc0ad025
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Does 18F-FDG positron emission tomography-computed tomography have a role in initial staging of hepatocellular carcinoma?

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