Eradication of Helicobacter pylori may improve dyspepsia in the elderly for the long term

Abstract Background Therapy for eradication of Helicobacter pylori (H. pylori) improves symptoms of H. pylori-associated dyspepsia (HPD), but the effects of eradication in elderly patients are unclear. The aim of our study was to investigate dyspepsia symptoms and long-term effects of eradication in...

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Autores principales:	Ikko Tanaka, Shoko Ono, Yoshihiko Shimoda, Masaki Inoue, Sayoko Kinowaki, Momoko Tsuda, Masayoshi Ono, Keiko Yamamoto, Yuichi Shimizu, Mototsugu Kato, Naoya Sakamoto
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Dyspepsia Helicobacter pylori Eradication therapy The elderly Diseases of the digestive system. Gastroenterology RC799-869
Acceso en línea:	https://doaj.org/article/d014dc07ae624546a1c27709bb6054ef
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spelling	oai:doaj.org-article:d014dc07ae624546a1c27709bb6054ef2021-11-28T12:14:55ZEradication of Helicobacter pylori may improve dyspepsia in the elderly for the long term10.1186/s12876-021-02027-61471-230Xhttps://doaj.org/article/d014dc07ae624546a1c27709bb6054ef2021-11-01T00:00:00Zhttps://doi.org/10.1186/s12876-021-02027-6https://doaj.org/toc/1471-230XAbstract Background Therapy for eradication of Helicobacter pylori (H. pylori) improves symptoms of H. pylori-associated dyspepsia (HPD), but the effects of eradication in elderly patients are unclear. The aim of our study was to investigate dyspepsia symptoms and long-term effects of eradication in elderly patients. Methods This retrospective study included 496 patients who received H. pylori eradication therapy. The patients were divided into a group of elderly patients (group E: ≧ 65 years old) and a group of non-elderly patients (group N: < 65 years old). Abdominal symptoms were evaluated using a questionnaire about abdominal symptoms before eradication and after eradication (1–2 months and more than one year). Dyspepsia was defined as a score of 4 points or more for at least one of 4 items (postprandial fullness, early satiety, epigastric pain, and hunger pain). Improvement of symptoms was defined on the basis of changes in Global Overall Systems scores. Results There were no differences in abdominal symptoms before eradication between the two groups. Successful eradication improved symptoms in patients with dyspepsia within 2 months (in 75.6% (56/74) of the patients in group N and in 64.5% (20/31) of the patients in group E). The questionnaire showed that 80% (32/40) of the patients in group N and 60% (12/20) of the patients in group E had long-term relief of dyspepsia. The scores for abdominal symptoms in group E continued to improve for a mean period of 54.8 months after eradication. Conclusions Eradication of H. pylori age-independently improved dyspepsia symptoms for the long term.Ikko TanakaShoko OnoYoshihiko ShimodaMasaki InoueSayoko KinowakiMomoko TsudaMasayoshi OnoKeiko YamamotoYuichi ShimizuMototsugu KatoNaoya SakamotoBMCarticleDyspepsiaHelicobacter pyloriEradication therapyThe elderlyDiseases of the digestive system. GastroenterologyRC799-869ENBMC Gastroenterology, Vol 21, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Dyspepsia Helicobacter pylori Eradication therapy The elderly Diseases of the digestive system. Gastroenterology RC799-869
spellingShingle	Dyspepsia Helicobacter pylori Eradication therapy The elderly Diseases of the digestive system. Gastroenterology RC799-869 Ikko Tanaka Shoko Ono Yoshihiko Shimoda Masaki Inoue Sayoko Kinowaki Momoko Tsuda Masayoshi Ono Keiko Yamamoto Yuichi Shimizu Mototsugu Kato Naoya Sakamoto Eradication of Helicobacter pylori may improve dyspepsia in the elderly for the long term
description	Abstract Background Therapy for eradication of Helicobacter pylori (H. pylori) improves symptoms of H. pylori-associated dyspepsia (HPD), but the effects of eradication in elderly patients are unclear. The aim of our study was to investigate dyspepsia symptoms and long-term effects of eradication in elderly patients. Methods This retrospective study included 496 patients who received H. pylori eradication therapy. The patients were divided into a group of elderly patients (group E: ≧ 65 years old) and a group of non-elderly patients (group N: < 65 years old). Abdominal symptoms were evaluated using a questionnaire about abdominal symptoms before eradication and after eradication (1–2 months and more than one year). Dyspepsia was defined as a score of 4 points or more for at least one of 4 items (postprandial fullness, early satiety, epigastric pain, and hunger pain). Improvement of symptoms was defined on the basis of changes in Global Overall Systems scores. Results There were no differences in abdominal symptoms before eradication between the two groups. Successful eradication improved symptoms in patients with dyspepsia within 2 months (in 75.6% (56/74) of the patients in group N and in 64.5% (20/31) of the patients in group E). The questionnaire showed that 80% (32/40) of the patients in group N and 60% (12/20) of the patients in group E had long-term relief of dyspepsia. The scores for abdominal symptoms in group E continued to improve for a mean period of 54.8 months after eradication. Conclusions Eradication of H. pylori age-independently improved dyspepsia symptoms for the long term.
format	article
author	Ikko Tanaka Shoko Ono Yoshihiko Shimoda Masaki Inoue Sayoko Kinowaki Momoko Tsuda Masayoshi Ono Keiko Yamamoto Yuichi Shimizu Mototsugu Kato Naoya Sakamoto
author_facet	Ikko Tanaka Shoko Ono Yoshihiko Shimoda Masaki Inoue Sayoko Kinowaki Momoko Tsuda Masayoshi Ono Keiko Yamamoto Yuichi Shimizu Mototsugu Kato Naoya Sakamoto
author_sort	Ikko Tanaka
title	Eradication of Helicobacter pylori may improve dyspepsia in the elderly for the long term
title_short	Eradication of Helicobacter pylori may improve dyspepsia in the elderly for the long term
title_full	Eradication of Helicobacter pylori may improve dyspepsia in the elderly for the long term
title_fullStr	Eradication of Helicobacter pylori may improve dyspepsia in the elderly for the long term
title_full_unstemmed	Eradication of Helicobacter pylori may improve dyspepsia in the elderly for the long term
title_sort	eradication of helicobacter pylori may improve dyspepsia in the elderly for the long term
publisher	BMC
publishDate	2021
url	https://doaj.org/article/d014dc07ae624546a1c27709bb6054ef
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Eradication of Helicobacter pylori may improve dyspepsia in the elderly for the long term

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