Ceramide Remodeling and Risk of Cardiovascular Events and Mortality

BackgroundRecent studies suggest that circulating concentrations of specific ceramide species may be associated with coronary risk and mortality. We sought to determine the relations between the most abundant plasma ceramide species of differing acyl chain lengths and the risk of coronary heart dise...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Linda R. Peterson, Vanessa Xanthakis, Meredith S. Duncan, Stefan Gross, Nele Friedrich, Henry Völzke, Stephan B. Felix, Hui Jiang, Rohini Sidhu, Matthias Nauck, Xuntian Jiang, Daniel S. Ory, Marcus Dörr, Ramachandran S. Vasan, Jean E. Schaffer
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2018
Materias:	cardiovascular disease risk factors ceramides mortality Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/d01b8de6f1be44618c9fb0f3db3e2e1c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d01b8de6f1be44618c9fb0f3db3e2e1c
record_format	dspace
spelling	oai:doaj.org-article:d01b8de6f1be44618c9fb0f3db3e2e1c2021-11-12T17:01:54ZCeramide Remodeling and Risk of Cardiovascular Events and Mortality10.1161/JAHA.117.0079312047-9980https://doaj.org/article/d01b8de6f1be44618c9fb0f3db3e2e1c2018-05-01T00:00:00Zhttps://www.ahajournals.org/doi/10.1161/JAHA.117.007931https://doaj.org/toc/2047-9980BackgroundRecent studies suggest that circulating concentrations of specific ceramide species may be associated with coronary risk and mortality. We sought to determine the relations between the most abundant plasma ceramide species of differing acyl chain lengths and the risk of coronary heart disease (CHD) and mortality in community‐based samples. Methods and ResultsWe developed a liquid chromatography/mass spectrometry assay to quantify plasma C24:0, C22:0, and C16:0 ceramides and ratios of these very–long‐chain/long‐chain ceramides in 2642 FHS (Framingham Heart Study) participants and in 3134 SHIP (Study of Health in Pomerania) participants. Over a mean follow‐up of 6 years in FHS, there were 88 CHD and 90 heart failure (HF) events and 239 deaths. Over a median follow‐up time in SHIP of 5.75 years for CHD and HF and 8.24 years for mortality, there were 209 CHD and 146 HF events and 377 deaths. In meta‐analysis of the 2 cohorts and adjusting for standard CHD risk factors, C24:0/C16:0 ceramide ratios were inversely associated with incident CHD (hazard ratio per average SD increment, 0.79; 95% confidence interval, 0.71–0.89; P<0.0001) and inversely associated with incident HF (hazard ratio, 0.78; 95% confidence interval, 0.61–1.00; P=0.046). Moreover, the C24:0/C16:0 and C22:0/C16:0 ceramide ratios were inversely associated with all‐cause mortality (C24:0/C16:0: hazard ratio, 0.60; 95% confidence interval, 0.56–0.65; P<0.0001; C22:0/C16:0: hazard ratio, 0.65; 95% confidence interval, 0.60–0.70; P<0.0001). ConclusionsThe ratio of C24:0/C16:0 ceramides in blood may be a valuable new biomarker of CHD risk, HF risk, and all‐cause mortality in the community.Linda R. PetersonVanessa XanthakisMeredith S. DuncanStefan GrossNele FriedrichHenry VölzkeStephan B. FelixHui JiangRohini SidhuMatthias NauckXuntian JiangDaniel S. OryMarcus DörrRamachandran S. VasanJean E. SchafferWileyarticlecardiovascular disease risk factorsceramidesmortalityDiseases of the circulatory (Cardiovascular) systemRC666-701ENJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 7, Iss 10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	cardiovascular disease risk factors ceramides mortality Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	cardiovascular disease risk factors ceramides mortality Diseases of the circulatory (Cardiovascular) system RC666-701 Linda R. Peterson Vanessa Xanthakis Meredith S. Duncan Stefan Gross Nele Friedrich Henry Völzke Stephan B. Felix Hui Jiang Rohini Sidhu Matthias Nauck Xuntian Jiang Daniel S. Ory Marcus Dörr Ramachandran S. Vasan Jean E. Schaffer Ceramide Remodeling and Risk of Cardiovascular Events and Mortality
description	BackgroundRecent studies suggest that circulating concentrations of specific ceramide species may be associated with coronary risk and mortality. We sought to determine the relations between the most abundant plasma ceramide species of differing acyl chain lengths and the risk of coronary heart disease (CHD) and mortality in community‐based samples. Methods and ResultsWe developed a liquid chromatography/mass spectrometry assay to quantify plasma C24:0, C22:0, and C16:0 ceramides and ratios of these very–long‐chain/long‐chain ceramides in 2642 FHS (Framingham Heart Study) participants and in 3134 SHIP (Study of Health in Pomerania) participants. Over a mean follow‐up of 6 years in FHS, there were 88 CHD and 90 heart failure (HF) events and 239 deaths. Over a median follow‐up time in SHIP of 5.75 years for CHD and HF and 8.24 years for mortality, there were 209 CHD and 146 HF events and 377 deaths. In meta‐analysis of the 2 cohorts and adjusting for standard CHD risk factors, C24:0/C16:0 ceramide ratios were inversely associated with incident CHD (hazard ratio per average SD increment, 0.79; 95% confidence interval, 0.71–0.89; P<0.0001) and inversely associated with incident HF (hazard ratio, 0.78; 95% confidence interval, 0.61–1.00; P=0.046). Moreover, the C24:0/C16:0 and C22:0/C16:0 ceramide ratios were inversely associated with all‐cause mortality (C24:0/C16:0: hazard ratio, 0.60; 95% confidence interval, 0.56–0.65; P<0.0001; C22:0/C16:0: hazard ratio, 0.65; 95% confidence interval, 0.60–0.70; P<0.0001). ConclusionsThe ratio of C24:0/C16:0 ceramides in blood may be a valuable new biomarker of CHD risk, HF risk, and all‐cause mortality in the community.
format	article
author	Linda R. Peterson Vanessa Xanthakis Meredith S. Duncan Stefan Gross Nele Friedrich Henry Völzke Stephan B. Felix Hui Jiang Rohini Sidhu Matthias Nauck Xuntian Jiang Daniel S. Ory Marcus Dörr Ramachandran S. Vasan Jean E. Schaffer
author_facet	Linda R. Peterson Vanessa Xanthakis Meredith S. Duncan Stefan Gross Nele Friedrich Henry Völzke Stephan B. Felix Hui Jiang Rohini Sidhu Matthias Nauck Xuntian Jiang Daniel S. Ory Marcus Dörr Ramachandran S. Vasan Jean E. Schaffer
author_sort	Linda R. Peterson
title	Ceramide Remodeling and Risk of Cardiovascular Events and Mortality
title_short	Ceramide Remodeling and Risk of Cardiovascular Events and Mortality
title_full	Ceramide Remodeling and Risk of Cardiovascular Events and Mortality
title_fullStr	Ceramide Remodeling and Risk of Cardiovascular Events and Mortality
title_full_unstemmed	Ceramide Remodeling and Risk of Cardiovascular Events and Mortality
title_sort	ceramide remodeling and risk of cardiovascular events and mortality
publisher	Wiley
publishDate	2018
url	https://doaj.org/article/d01b8de6f1be44618c9fb0f3db3e2e1c
work_keys_str_mv	AT lindarpeterson ceramideremodelingandriskofcardiovasculareventsandmortality AT vanessaxanthakis ceramideremodelingandriskofcardiovasculareventsandmortality AT meredithsduncan ceramideremodelingandriskofcardiovasculareventsandmortality AT stefangross ceramideremodelingandriskofcardiovasculareventsandmortality AT nelefriedrich ceramideremodelingandriskofcardiovasculareventsandmortality AT henryvolzke ceramideremodelingandriskofcardiovasculareventsandmortality AT stephanbfelix ceramideremodelingandriskofcardiovasculareventsandmortality AT huijiang ceramideremodelingandriskofcardiovasculareventsandmortality AT rohinisidhu ceramideremodelingandriskofcardiovasculareventsandmortality AT matthiasnauck ceramideremodelingandriskofcardiovasculareventsandmortality AT xuntianjiang ceramideremodelingandriskofcardiovasculareventsandmortality AT danielsory ceramideremodelingandriskofcardiovasculareventsandmortality AT marcusdorr ceramideremodelingandriskofcardiovasculareventsandmortality AT ramachandransvasan ceramideremodelingandriskofcardiovasculareventsandmortality AT jeaneschaffer ceramideremodelingandriskofcardiovasculareventsandmortality
_version_	1718430399887048704

Ceramide Remodeling and Risk of Cardiovascular Events and Mortality

Ejemplares similares