Trends in the incidence and mortality of legionellosis in Japan: a nationwide observational study, 1999–2017

Abstract This study examined temporal trend, seasonality, and geographical variations of legionellosis incidence and mortality in Japan. This nationwide observational study used the Japanese Vital Statistics and Infectious Diseases Weekly Report (1999–2017) data to calculate legionellosis crude and...

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Autores principales:	Shinnosuke Fukushima, Hideharu Hagiya, Yuki Otsuka, Toshihiro Koyama, Fumio Otsuka
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d01ee84a5d84400fae8b7fe7c0cf8556
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spelling	oai:doaj.org-article:d01ee84a5d84400fae8b7fe7c0cf85562021-12-02T13:26:58ZTrends in the incidence and mortality of legionellosis in Japan: a nationwide observational study, 1999–201710.1038/s41598-021-86431-82045-2322https://doaj.org/article/d01ee84a5d84400fae8b7fe7c0cf85562021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86431-8https://doaj.org/toc/2045-2322Abstract This study examined temporal trend, seasonality, and geographical variations of legionellosis incidence and mortality in Japan. This nationwide observational study used the Japanese Vital Statistics and Infectious Diseases Weekly Report (1999–2017) data to calculate legionellosis crude and age-adjusted incidence and mortality rates per 100,000 population by age and sex. Incidence was compared among the 4 seasons and regional incidence among 47 prefectures. Of 13,613 (11,194 men) people with legionellosis in Japan, 725 (569 men) were fatal. Increasing incidence trend occurred from 0.0004 (1999) to 1.37 (2017) per 100,000 population. People aged ≥ 70 years accounted for 43.1% overall; men’s age-adjusted incidence rate was consistently approximately five times higher than for women. Significantly higher incidence occurred in summer than in winter (p = 0.013). Geographically, highest incidence (≥ 2.0 per 100,000 population) occurred in Hokuriku District, with increasing trends in Hokkaido and middle-part of Japan. Estimated fatality rates decreased consistently at 5.9% (95% confidence interval: − 8.1, − 3.5) annually, from 1999 to 2017, with no trend change point. Increasing legionellosis incidence occurred in Japan during 1999–2017, with declining estimated fatality rates. In this aging society and warming world, disease clinical burden may further deteriorate in future due to increasing incidence trends.Shinnosuke FukushimaHideharu HagiyaYuki OtsukaToshihiro KoyamaFumio OtsukaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shinnosuke Fukushima Hideharu Hagiya Yuki Otsuka Toshihiro Koyama Fumio Otsuka Trends in the incidence and mortality of legionellosis in Japan: a nationwide observational study, 1999–2017
description	Abstract This study examined temporal trend, seasonality, and geographical variations of legionellosis incidence and mortality in Japan. This nationwide observational study used the Japanese Vital Statistics and Infectious Diseases Weekly Report (1999–2017) data to calculate legionellosis crude and age-adjusted incidence and mortality rates per 100,000 population by age and sex. Incidence was compared among the 4 seasons and regional incidence among 47 prefectures. Of 13,613 (11,194 men) people with legionellosis in Japan, 725 (569 men) were fatal. Increasing incidence trend occurred from 0.0004 (1999) to 1.37 (2017) per 100,000 population. People aged ≥ 70 years accounted for 43.1% overall; men’s age-adjusted incidence rate was consistently approximately five times higher than for women. Significantly higher incidence occurred in summer than in winter (p = 0.013). Geographically, highest incidence (≥ 2.0 per 100,000 population) occurred in Hokuriku District, with increasing trends in Hokkaido and middle-part of Japan. Estimated fatality rates decreased consistently at 5.9% (95% confidence interval: − 8.1, − 3.5) annually, from 1999 to 2017, with no trend change point. Increasing legionellosis incidence occurred in Japan during 1999–2017, with declining estimated fatality rates. In this aging society and warming world, disease clinical burden may further deteriorate in future due to increasing incidence trends.
format	article
author	Shinnosuke Fukushima Hideharu Hagiya Yuki Otsuka Toshihiro Koyama Fumio Otsuka
author_facet	Shinnosuke Fukushima Hideharu Hagiya Yuki Otsuka Toshihiro Koyama Fumio Otsuka
author_sort	Shinnosuke Fukushima
title	Trends in the incidence and mortality of legionellosis in Japan: a nationwide observational study, 1999–2017
title_short	Trends in the incidence and mortality of legionellosis in Japan: a nationwide observational study, 1999–2017
title_full	Trends in the incidence and mortality of legionellosis in Japan: a nationwide observational study, 1999–2017
title_fullStr	Trends in the incidence and mortality of legionellosis in Japan: a nationwide observational study, 1999–2017
title_full_unstemmed	Trends in the incidence and mortality of legionellosis in Japan: a nationwide observational study, 1999–2017
title_sort	trends in the incidence and mortality of legionellosis in japan: a nationwide observational study, 1999–2017
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d01ee84a5d84400fae8b7fe7c0cf8556
work_keys_str_mv	AT shinnosukefukushima trendsintheincidenceandmortalityoflegionellosisinjapananationwideobservationalstudy19992017 AT hideharuhagiya trendsintheincidenceandmortalityoflegionellosisinjapananationwideobservationalstudy19992017 AT yukiotsuka trendsintheincidenceandmortalityoflegionellosisinjapananationwideobservationalstudy19992017 AT toshihirokoyama trendsintheincidenceandmortalityoflegionellosisinjapananationwideobservationalstudy19992017 AT fumiootsuka trendsintheincidenceandmortalityoflegionellosisinjapananationwideobservationalstudy19992017
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Trends in the incidence and mortality of legionellosis in Japan: a nationwide observational study, 1999–2017

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