Effect of Coenzyme-Q10 in Congestive Heart Failure

BACKGROUND AND OBJECTIVE: Coenzyme Q10 (CoQ10) is a provitamin existing in mitocondrial and cellular membranes scavenging free radicals as an antioxidant. This coenzyme also has important role in providing energy in cardiomyocites. Levels of CoQ10 decrease in heart failure. The treatment of severe c...

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Autores principales:	SF Jalali, M Baradaran, M Mahdinejad Shani, N Rooshan
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2010
Materias:	congestive heart failure coenzyme- q10 dilated cardiomyopathy coronary artery disease end systolic diameter end diastolic diameter Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/d01f465b6e944fc18ff69170018d9ecf
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spelling	oai:doaj.org-article:d01f465b6e944fc18ff69170018d9ecf2021-11-10T09:00:22ZEffect of Coenzyme-Q10 in Congestive Heart Failure1561-41072251-7170https://doaj.org/article/d01f465b6e944fc18ff69170018d9ecf2010-06-01T00:00:00Zhttp://jbums.org/article-1-3469-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: Coenzyme Q10 (CoQ10) is a provitamin existing in mitocondrial and cellular membranes scavenging free radicals as an antioxidant. This coenzyme also has important role in providing energy in cardiomyocites. Levels of CoQ10 decrease in heart failure. The treatment of severe congestive heart failure is one of the problems in cardiac patients. The aim of this study was to determine the effect of oral administration of CoQ10 in chronic heart failure. METHODS: This quasi-experimental study was carried out on 47 patients with congestive heart failure (CLASS III-IV NYHA). In all patients MM, 2D, and Doppler echocardiography were performed and after that they received oral CoQ10 (100 mg) (red-CoQ10) as daily single dose during next three months. After treatment, echocardiography was performed again and the data including left ventricle size, end systolic diameter, end diastolic diameter and severity of MR before and after treatment were compared and analyzed.FINDINGS: The mean±SD was 60.5±12.8 years. Thirty patients (63.8%) were male and 17 patients (36.2%) were female. More than 10 mm decreases were observed in: left ventricle size (in 8.5%), end systolic diameter (in 12.8%), end diastolic diameter (in 19.1%) and increase in ejection fraction in 70.2% of patients that indicated significant differences as compared to before treatment (p=0.000). In dilated cardiomyopathy, more than 10 mm decreases were observed in: left ventricle size, end systolic diameter, and end diastolic diameter in 7.4%, 14.8% and 11.1% of patients, respectively. But in coronary artery disease, more than 10 mm decreases were observed in: left ventricle size, end systolic diameter, and end diastolic diameter in 9.1%, 18.2%, and 45.4% of patients, respectively. Increases in ejection fraction were 74.1% and 63.6% in dilated cardiomyopathy and coronary artery disease, respectively. CONCLUSION: Based on obtained results, supplementing patients cardiac medicines with CoQ10 made significant improvements in ejection fraction. Additionally, the results of this study show that CoQ10 is effective in coronary artery disease.SF Jalali,M BaradaranM Mahdinejad Shani,N RooshanBabol University of Medical Sciencesarticlecongestive heart failurecoenzyme- q10dilated cardiomyopathycoronary artery diseaseend systolic diameterend diastolic diameterMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 12, Iss 2, Pp 24-29 (2010)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	congestive heart failure coenzyme- q10 dilated cardiomyopathy coronary artery disease end systolic diameter end diastolic diameter Medicine R Medicine (General) R5-920
spellingShingle	congestive heart failure coenzyme- q10 dilated cardiomyopathy coronary artery disease end systolic diameter end diastolic diameter Medicine R Medicine (General) R5-920 SF Jalali, M Baradaran M Mahdinejad Shani, N Rooshan Effect of Coenzyme-Q10 in Congestive Heart Failure
description	BACKGROUND AND OBJECTIVE: Coenzyme Q10 (CoQ10) is a provitamin existing in mitocondrial and cellular membranes scavenging free radicals as an antioxidant. This coenzyme also has important role in providing energy in cardiomyocites. Levels of CoQ10 decrease in heart failure. The treatment of severe congestive heart failure is one of the problems in cardiac patients. The aim of this study was to determine the effect of oral administration of CoQ10 in chronic heart failure. METHODS: This quasi-experimental study was carried out on 47 patients with congestive heart failure (CLASS III-IV NYHA). In all patients MM, 2D, and Doppler echocardiography were performed and after that they received oral CoQ10 (100 mg) (red-CoQ10) as daily single dose during next three months. After treatment, echocardiography was performed again and the data including left ventricle size, end systolic diameter, end diastolic diameter and severity of MR before and after treatment were compared and analyzed.FINDINGS: The mean±SD was 60.5±12.8 years. Thirty patients (63.8%) were male and 17 patients (36.2%) were female. More than 10 mm decreases were observed in: left ventricle size (in 8.5%), end systolic diameter (in 12.8%), end diastolic diameter (in 19.1%) and increase in ejection fraction in 70.2% of patients that indicated significant differences as compared to before treatment (p=0.000). In dilated cardiomyopathy, more than 10 mm decreases were observed in: left ventricle size, end systolic diameter, and end diastolic diameter in 7.4%, 14.8% and 11.1% of patients, respectively. But in coronary artery disease, more than 10 mm decreases were observed in: left ventricle size, end systolic diameter, and end diastolic diameter in 9.1%, 18.2%, and 45.4% of patients, respectively. Increases in ejection fraction were 74.1% and 63.6% in dilated cardiomyopathy and coronary artery disease, respectively. CONCLUSION: Based on obtained results, supplementing patients cardiac medicines with CoQ10 made significant improvements in ejection fraction. Additionally, the results of this study show that CoQ10 is effective in coronary artery disease.
format	article
author	SF Jalali, M Baradaran M Mahdinejad Shani, N Rooshan
author_facet	SF Jalali, M Baradaran M Mahdinejad Shani, N Rooshan
author_sort	SF Jalali,
title	Effect of Coenzyme-Q10 in Congestive Heart Failure
title_short	Effect of Coenzyme-Q10 in Congestive Heart Failure
title_full	Effect of Coenzyme-Q10 in Congestive Heart Failure
title_fullStr	Effect of Coenzyme-Q10 in Congestive Heart Failure
title_full_unstemmed	Effect of Coenzyme-Q10 in Congestive Heart Failure
title_sort	effect of coenzyme-q10 in congestive heart failure
publisher	Babol University of Medical Sciences
publishDate	2010
url	https://doaj.org/article/d01f465b6e944fc18ff69170018d9ecf
work_keys_str_mv	AT sfjalali effectofcoenzymeq10incongestiveheartfailure AT mbaradaran effectofcoenzymeq10incongestiveheartfailure AT mmahdinejadshani effectofcoenzymeq10incongestiveheartfailure AT nrooshan effectofcoenzymeq10incongestiveheartfailure
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Effect of Coenzyme-Q10 in Congestive Heart Failure

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