Characterizing and Exploiting Tumor Microenvironments to Optimize Treatment Outcomes

Our understanding of cancer initiation, progression, and treatment is continually progressing through dedicated research achieved through laboratory investigation, clinical trials, and patient engagement. The importance and complexity of the microenvironment and its role in tumor development and beh...

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Autores principales: Emma H. Allott, Kellie Dean, Tracy Robson, Claire Meaney
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
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Acceso en línea:https://doaj.org/article/d02755942e234a3c9d86c3bca3f79574
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spelling oai:doaj.org-article:d02755942e234a3c9d86c3bca3f795742021-11-25T17:03:35ZCharacterizing and Exploiting Tumor Microenvironments to Optimize Treatment Outcomes10.3390/cancers132257522072-6694https://doaj.org/article/d02755942e234a3c9d86c3bca3f795742021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/22/5752https://doaj.org/toc/2072-6694Our understanding of cancer initiation, progression, and treatment is continually progressing through dedicated research achieved through laboratory investigation, clinical trials, and patient engagement. The importance and complexity of the microenvironment and its role in tumor development and behavior is pivotal to the understanding of tumor growth and the best course of treatment. The 57th Irish Association for Cancer Research (IACR) Annual Conference collected key researchers, clinicians, and patient advocates together to highlight and discuss the recognized importance of the microenvironment and treatment advances in cancer. In this article, we describe the key components of the microenvironment that influence tumor development and treatment, including the microbiome, metabolism, and immune response and the progress of preclinical models to reflect these complex environments. From a psycho-social oncology perspective, we highlight expert opinion and data on the process of shared decision-making in the context of emerging cancer treatments.Emma H. AllottKellie DeanTracy RobsonClaire MeaneyMDPI AGarticlemicroenvironmentimmune systemmicrobiomepreclinical modelsorganoidsgenetically engineered mouse modelsNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5752, p 5752 (2021)
institution DOAJ
collection DOAJ
language EN
topic microenvironment
immune system
microbiome
preclinical models
organoids
genetically engineered mouse models
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
spellingShingle microenvironment
immune system
microbiome
preclinical models
organoids
genetically engineered mouse models
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Emma H. Allott
Kellie Dean
Tracy Robson
Claire Meaney
Characterizing and Exploiting Tumor Microenvironments to Optimize Treatment Outcomes
description Our understanding of cancer initiation, progression, and treatment is continually progressing through dedicated research achieved through laboratory investigation, clinical trials, and patient engagement. The importance and complexity of the microenvironment and its role in tumor development and behavior is pivotal to the understanding of tumor growth and the best course of treatment. The 57th Irish Association for Cancer Research (IACR) Annual Conference collected key researchers, clinicians, and patient advocates together to highlight and discuss the recognized importance of the microenvironment and treatment advances in cancer. In this article, we describe the key components of the microenvironment that influence tumor development and treatment, including the microbiome, metabolism, and immune response and the progress of preclinical models to reflect these complex environments. From a psycho-social oncology perspective, we highlight expert opinion and data on the process of shared decision-making in the context of emerging cancer treatments.
format article
author Emma H. Allott
Kellie Dean
Tracy Robson
Claire Meaney
author_facet Emma H. Allott
Kellie Dean
Tracy Robson
Claire Meaney
author_sort Emma H. Allott
title Characterizing and Exploiting Tumor Microenvironments to Optimize Treatment Outcomes
title_short Characterizing and Exploiting Tumor Microenvironments to Optimize Treatment Outcomes
title_full Characterizing and Exploiting Tumor Microenvironments to Optimize Treatment Outcomes
title_fullStr Characterizing and Exploiting Tumor Microenvironments to Optimize Treatment Outcomes
title_full_unstemmed Characterizing and Exploiting Tumor Microenvironments to Optimize Treatment Outcomes
title_sort characterizing and exploiting tumor microenvironments to optimize treatment outcomes
publisher MDPI AG
publishDate 2021
url https://doaj.org/article/d02755942e234a3c9d86c3bca3f79574
work_keys_str_mv AT emmahallott characterizingandexploitingtumormicroenvironmentstooptimizetreatmentoutcomes
AT kelliedean characterizingandexploitingtumormicroenvironmentstooptimizetreatmentoutcomes
AT tracyrobson characterizingandexploitingtumormicroenvironmentstooptimizetreatmentoutcomes
AT clairemeaney characterizingandexploitingtumormicroenvironmentstooptimizetreatmentoutcomes
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