Characterizing and Exploiting Tumor Microenvironments to Optimize Treatment Outcomes
Our understanding of cancer initiation, progression, and treatment is continually progressing through dedicated research achieved through laboratory investigation, clinical trials, and patient engagement. The importance and complexity of the microenvironment and its role in tumor development and beh...
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MDPI AG
2021
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oai:doaj.org-article:d02755942e234a3c9d86c3bca3f795742021-11-25T17:03:35ZCharacterizing and Exploiting Tumor Microenvironments to Optimize Treatment Outcomes10.3390/cancers132257522072-6694https://doaj.org/article/d02755942e234a3c9d86c3bca3f795742021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/22/5752https://doaj.org/toc/2072-6694Our understanding of cancer initiation, progression, and treatment is continually progressing through dedicated research achieved through laboratory investigation, clinical trials, and patient engagement. The importance and complexity of the microenvironment and its role in tumor development and behavior is pivotal to the understanding of tumor growth and the best course of treatment. The 57th Irish Association for Cancer Research (IACR) Annual Conference collected key researchers, clinicians, and patient advocates together to highlight and discuss the recognized importance of the microenvironment and treatment advances in cancer. In this article, we describe the key components of the microenvironment that influence tumor development and treatment, including the microbiome, metabolism, and immune response and the progress of preclinical models to reflect these complex environments. From a psycho-social oncology perspective, we highlight expert opinion and data on the process of shared decision-making in the context of emerging cancer treatments.Emma H. AllottKellie DeanTracy RobsonClaire MeaneyMDPI AGarticlemicroenvironmentimmune systemmicrobiomepreclinical modelsorganoidsgenetically engineered mouse modelsNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5752, p 5752 (2021) |
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microenvironment immune system microbiome preclinical models organoids genetically engineered mouse models Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 |
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microenvironment immune system microbiome preclinical models organoids genetically engineered mouse models Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Emma H. Allott Kellie Dean Tracy Robson Claire Meaney Characterizing and Exploiting Tumor Microenvironments to Optimize Treatment Outcomes |
description |
Our understanding of cancer initiation, progression, and treatment is continually progressing through dedicated research achieved through laboratory investigation, clinical trials, and patient engagement. The importance and complexity of the microenvironment and its role in tumor development and behavior is pivotal to the understanding of tumor growth and the best course of treatment. The 57th Irish Association for Cancer Research (IACR) Annual Conference collected key researchers, clinicians, and patient advocates together to highlight and discuss the recognized importance of the microenvironment and treatment advances in cancer. In this article, we describe the key components of the microenvironment that influence tumor development and treatment, including the microbiome, metabolism, and immune response and the progress of preclinical models to reflect these complex environments. From a psycho-social oncology perspective, we highlight expert opinion and data on the process of shared decision-making in the context of emerging cancer treatments. |
format |
article |
author |
Emma H. Allott Kellie Dean Tracy Robson Claire Meaney |
author_facet |
Emma H. Allott Kellie Dean Tracy Robson Claire Meaney |
author_sort |
Emma H. Allott |
title |
Characterizing and Exploiting Tumor Microenvironments to Optimize Treatment Outcomes |
title_short |
Characterizing and Exploiting Tumor Microenvironments to Optimize Treatment Outcomes |
title_full |
Characterizing and Exploiting Tumor Microenvironments to Optimize Treatment Outcomes |
title_fullStr |
Characterizing and Exploiting Tumor Microenvironments to Optimize Treatment Outcomes |
title_full_unstemmed |
Characterizing and Exploiting Tumor Microenvironments to Optimize Treatment Outcomes |
title_sort |
characterizing and exploiting tumor microenvironments to optimize treatment outcomes |
publisher |
MDPI AG |
publishDate |
2021 |
url |
https://doaj.org/article/d02755942e234a3c9d86c3bca3f79574 |
work_keys_str_mv |
AT emmahallott characterizingandexploitingtumormicroenvironmentstooptimizetreatmentoutcomes AT kelliedean characterizingandexploitingtumormicroenvironmentstooptimizetreatmentoutcomes AT tracyrobson characterizingandexploitingtumormicroenvironmentstooptimizetreatmentoutcomes AT clairemeaney characterizingandexploitingtumormicroenvironmentstooptimizetreatmentoutcomes |
_version_ |
1718412805227413504 |