SUBPOPULATIONAL FEATURES OF PERIPHERAL BLOOD CELLS IN THE PATIENTS WITH AUTOIMMUNE MYOCARDITIS: CLINICAL AND PATHOGENETIC ASPECTS

Abstract. The goal of our research was comparative study of the most important parameters of subset cytoarchitectonics in the patients with the different courses of myocarditis and evaluation of their pathogenetic and clinical value in the practice of the physician. We have investigated 99 patients...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	N. N. Kekenadze, Z. S. Shogenov, E. V. Kalinina, O. A. Pronina, B. V. Pinegin, M. A. Zemtsova, T. Elbeik, K. A. Maltsev, N. V. Gnuchev, S. V. Suchkov
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	lymphocytes subpopulation myocarditis autoimmunity flow cytometry Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/d0288de77438466bb10b4a5a01f97266
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d0288de77438466bb10b4a5a01f97266
record_format	dspace
spelling	oai:doaj.org-article:d0288de77438466bb10b4a5a01f972662021-11-18T08:03:43ZSUBPOPULATIONAL FEATURES OF PERIPHERAL BLOOD CELLS IN THE PATIENTS WITH AUTOIMMUNE MYOCARDITIS: CLINICAL AND PATHOGENETIC ASPECTS1563-06252313-741X10.15789/1563-0625-2005-5-6-517-524https://doaj.org/article/d0288de77438466bb10b4a5a01f972662014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/603https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. The goal of our research was comparative study of the most important parameters of subset cytoarchitectonics in the patients with the different courses of myocarditis and evaluation of their pathogenetic and clinical value in the practice of the physician. We have investigated 99 patients with myocarditis and 40 healthy donors. In patients with malignant course of disease we revealed increased activation index of T/B-cells; increased expression of the activation markers on the both lines of differentiation; disproportion in the immunoregulatory subsets with increased role of dendric cells; decreased intensity of the autoreactive T-cells apoptosis. in the patient with the In patients with nonmalignant course of disease expressed signs of immunopathology were not found. Thus, study of activation markers on the cells of the peripheral blood is more informative and noninvasive method of diagnostics of myocarditis.N. N. KekenadzeZ. S. ShogenovE. V. KalininaO. A. ProninaB. V. PineginM. A. ZemtsovaT. ElbeikK. A. MaltsevN. V. GnuchevS. V. SuchkovSPb RAACIarticlelymphocytes subpopulationmyocarditisautoimmunityflow cytometryImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 7, Iss 5-6, Pp 517-524 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	lymphocytes subpopulation myocarditis autoimmunity flow cytometry Immunologic diseases. Allergy RC581-607
spellingShingle	lymphocytes subpopulation myocarditis autoimmunity flow cytometry Immunologic diseases. Allergy RC581-607 N. N. Kekenadze Z. S. Shogenov E. V. Kalinina O. A. Pronina B. V. Pinegin M. A. Zemtsova T. Elbeik K. A. Maltsev N. V. Gnuchev S. V. Suchkov SUBPOPULATIONAL FEATURES OF PERIPHERAL BLOOD CELLS IN THE PATIENTS WITH AUTOIMMUNE MYOCARDITIS: CLINICAL AND PATHOGENETIC ASPECTS
description	Abstract. The goal of our research was comparative study of the most important parameters of subset cytoarchitectonics in the patients with the different courses of myocarditis and evaluation of their pathogenetic and clinical value in the practice of the physician. We have investigated 99 patients with myocarditis and 40 healthy donors. In patients with malignant course of disease we revealed increased activation index of T/B-cells; increased expression of the activation markers on the both lines of differentiation; disproportion in the immunoregulatory subsets with increased role of dendric cells; decreased intensity of the autoreactive T-cells apoptosis. in the patient with the In patients with nonmalignant course of disease expressed signs of immunopathology were not found. Thus, study of activation markers on the cells of the peripheral blood is more informative and noninvasive method of diagnostics of myocarditis.
format	article
author	N. N. Kekenadze Z. S. Shogenov E. V. Kalinina O. A. Pronina B. V. Pinegin M. A. Zemtsova T. Elbeik K. A. Maltsev N. V. Gnuchev S. V. Suchkov
author_facet	N. N. Kekenadze Z. S. Shogenov E. V. Kalinina O. A. Pronina B. V. Pinegin M. A. Zemtsova T. Elbeik K. A. Maltsev N. V. Gnuchev S. V. Suchkov
author_sort	N. N. Kekenadze
title	SUBPOPULATIONAL FEATURES OF PERIPHERAL BLOOD CELLS IN THE PATIENTS WITH AUTOIMMUNE MYOCARDITIS: CLINICAL AND PATHOGENETIC ASPECTS
title_short	SUBPOPULATIONAL FEATURES OF PERIPHERAL BLOOD CELLS IN THE PATIENTS WITH AUTOIMMUNE MYOCARDITIS: CLINICAL AND PATHOGENETIC ASPECTS
title_full	SUBPOPULATIONAL FEATURES OF PERIPHERAL BLOOD CELLS IN THE PATIENTS WITH AUTOIMMUNE MYOCARDITIS: CLINICAL AND PATHOGENETIC ASPECTS
title_fullStr	SUBPOPULATIONAL FEATURES OF PERIPHERAL BLOOD CELLS IN THE PATIENTS WITH AUTOIMMUNE MYOCARDITIS: CLINICAL AND PATHOGENETIC ASPECTS
title_full_unstemmed	SUBPOPULATIONAL FEATURES OF PERIPHERAL BLOOD CELLS IN THE PATIENTS WITH AUTOIMMUNE MYOCARDITIS: CLINICAL AND PATHOGENETIC ASPECTS
title_sort	subpopulational features of peripheral blood cells in the patients with autoimmune myocarditis: clinical and pathogenetic aspects
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/d0288de77438466bb10b4a5a01f97266
work_keys_str_mv	AT nnkekenadze subpopulationalfeaturesofperipheralbloodcellsinthepatientswithautoimmunemyocarditisclinicalandpathogeneticaspects AT zsshogenov subpopulationalfeaturesofperipheralbloodcellsinthepatientswithautoimmunemyocarditisclinicalandpathogeneticaspects AT evkalinina subpopulationalfeaturesofperipheralbloodcellsinthepatientswithautoimmunemyocarditisclinicalandpathogeneticaspects AT oapronina subpopulationalfeaturesofperipheralbloodcellsinthepatientswithautoimmunemyocarditisclinicalandpathogeneticaspects AT bvpinegin subpopulationalfeaturesofperipheralbloodcellsinthepatientswithautoimmunemyocarditisclinicalandpathogeneticaspects AT mazemtsova subpopulationalfeaturesofperipheralbloodcellsinthepatientswithautoimmunemyocarditisclinicalandpathogeneticaspects AT telbeik subpopulationalfeaturesofperipheralbloodcellsinthepatientswithautoimmunemyocarditisclinicalandpathogeneticaspects AT kamaltsev subpopulationalfeaturesofperipheralbloodcellsinthepatientswithautoimmunemyocarditisclinicalandpathogeneticaspects AT nvgnuchev subpopulationalfeaturesofperipheralbloodcellsinthepatientswithautoimmunemyocarditisclinicalandpathogeneticaspects AT svsuchkov subpopulationalfeaturesofperipheralbloodcellsinthepatientswithautoimmunemyocarditisclinicalandpathogeneticaspects
_version_	1718422448578232320

SUBPOPULATIONAL FEATURES OF PERIPHERAL BLOOD CELLS IN THE PATIENTS WITH AUTOIMMUNE MYOCARDITIS: CLINICAL AND PATHOGENETIC ASPECTS

Ejemplares similares