Oncolytic adenovirus programmed by synthetic gene circuit for cancer immunotherapy

It is difficult to improve the efficacy of oncolytic virotherapy due to immune system responses and limited understanding of population dynamics. Here the authors use synthetic biology gene circuits to control adenoviral replication and release of immunomodulators in hepatocellular carcinoma cells.

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Autores principales:	Huiya Huang, Yiqi Liu, Weixi Liao, Yubing Cao, Qiang Liu, Yakun Guo, Yinying Lu, Zhen Xie
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d02993ca48bb47c3813974088403a7cc
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spelling	oai:doaj.org-article:d02993ca48bb47c3813974088403a7cc2021-12-02T14:39:55ZOncolytic adenovirus programmed by synthetic gene circuit for cancer immunotherapy10.1038/s41467-019-12794-22041-1723https://doaj.org/article/d02993ca48bb47c3813974088403a7cc2019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12794-2https://doaj.org/toc/2041-1723It is difficult to improve the efficacy of oncolytic virotherapy due to immune system responses and limited understanding of population dynamics. Here the authors use synthetic biology gene circuits to control adenoviral replication and release of immunomodulators in hepatocellular carcinoma cells.Huiya HuangYiqi LiuWeixi LiaoYubing CaoQiang LiuYakun GuoYinying LuZhen XieNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Huiya Huang Yiqi Liu Weixi Liao Yubing Cao Qiang Liu Yakun Guo Yinying Lu Zhen Xie Oncolytic adenovirus programmed by synthetic gene circuit for cancer immunotherapy
description	It is difficult to improve the efficacy of oncolytic virotherapy due to immune system responses and limited understanding of population dynamics. Here the authors use synthetic biology gene circuits to control adenoviral replication and release of immunomodulators in hepatocellular carcinoma cells.
format	article
author	Huiya Huang Yiqi Liu Weixi Liao Yubing Cao Qiang Liu Yakun Guo Yinying Lu Zhen Xie
author_facet	Huiya Huang Yiqi Liu Weixi Liao Yubing Cao Qiang Liu Yakun Guo Yinying Lu Zhen Xie
author_sort	Huiya Huang
title	Oncolytic adenovirus programmed by synthetic gene circuit for cancer immunotherapy
title_short	Oncolytic adenovirus programmed by synthetic gene circuit for cancer immunotherapy
title_full	Oncolytic adenovirus programmed by synthetic gene circuit for cancer immunotherapy
title_fullStr	Oncolytic adenovirus programmed by synthetic gene circuit for cancer immunotherapy
title_full_unstemmed	Oncolytic adenovirus programmed by synthetic gene circuit for cancer immunotherapy
title_sort	oncolytic adenovirus programmed by synthetic gene circuit for cancer immunotherapy
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/d02993ca48bb47c3813974088403a7cc
work_keys_str_mv	AT huiyahuang oncolyticadenovirusprogrammedbysyntheticgenecircuitforcancerimmunotherapy AT yiqiliu oncolyticadenovirusprogrammedbysyntheticgenecircuitforcancerimmunotherapy AT weixiliao oncolyticadenovirusprogrammedbysyntheticgenecircuitforcancerimmunotherapy AT yubingcao oncolyticadenovirusprogrammedbysyntheticgenecircuitforcancerimmunotherapy AT qiangliu oncolyticadenovirusprogrammedbysyntheticgenecircuitforcancerimmunotherapy AT yakunguo oncolyticadenovirusprogrammedbysyntheticgenecircuitforcancerimmunotherapy AT yinyinglu oncolyticadenovirusprogrammedbysyntheticgenecircuitforcancerimmunotherapy AT zhenxie oncolyticadenovirusprogrammedbysyntheticgenecircuitforcancerimmunotherapy
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Oncolytic adenovirus programmed by synthetic gene circuit for cancer immunotherapy

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