Fabrication of fluorescent nanospheres by heating PEGylated tetratyrosine nanofibers

Abstract Aromatic polypeptides have recently drawn the interest of the research community for their capability to self-assemble into a variety of functional nanostructures. Due to their interesting mechanical, electrical and optical properties, these nanostructures have been proposed as innovative m...

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Autores principales:	Enrico Gallo, Carlo Diaferia, Nicole Balasco, Teresa Sibillano, Valentina Roviello, Cinzia Giannini, Luigi Vitagliano, Giancarlo Morelli, Antonella Accardo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d02abcc8d1c44c5e8780c8f89e6de57b
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spelling	oai:doaj.org-article:d02abcc8d1c44c5e8780c8f89e6de57b2021-12-02T14:16:26ZFabrication of fluorescent nanospheres by heating PEGylated tetratyrosine nanofibers10.1038/s41598-020-79396-72045-2322https://doaj.org/article/d02abcc8d1c44c5e8780c8f89e6de57b2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79396-7https://doaj.org/toc/2045-2322Abstract Aromatic polypeptides have recently drawn the interest of the research community for their capability to self-assemble into a variety of functional nanostructures. Due to their interesting mechanical, electrical and optical properties, these nanostructures have been proposed as innovative materials in different biomedical, biotechnological and industrial fields. Recently, several efforts have been employed in the development of these innovative materials as nanoscale fluorescence (FL) imaging probes. In this context, we describe the synthesis and the functional properties of a novel fluorescent tyrosine (Tyr, Y)-based nanospheres, obtained by heating at 200 °C a solution of the PEGylated tetra-peptide PEG6-Y4. At room temperature, this peptide self-assembles into not fluorescent low ordered water-soluble fibrillary aggregates. After heating, the aggregation of different polyphenolic species generates Y4-based nanospheres able to emit FL into blue, green and red spectral regions, both in solution and at the solid state. The aggregation features of PEG6-Y4 before and after heating were studied using a set of complementary techniques (Fluorescence, CD, FT-IR, Small and Wide-Angle X-ray Scattering and SEM). After a deep investigation of their optoelectronic properties, these nanospheres could be exploited as promising tools for precise biomedicine in advanced nanomedical technologies (local bioimaging, light diagnostics, therapy, optogenetics and health monitoring).Enrico GalloCarlo DiaferiaNicole BalascoTeresa SibillanoValentina RovielloCinzia GianniniLuigi VitaglianoGiancarlo MorelliAntonella AccardoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Enrico Gallo Carlo Diaferia Nicole Balasco Teresa Sibillano Valentina Roviello Cinzia Giannini Luigi Vitagliano Giancarlo Morelli Antonella Accardo Fabrication of fluorescent nanospheres by heating PEGylated tetratyrosine nanofibers
description	Abstract Aromatic polypeptides have recently drawn the interest of the research community for their capability to self-assemble into a variety of functional nanostructures. Due to their interesting mechanical, electrical and optical properties, these nanostructures have been proposed as innovative materials in different biomedical, biotechnological and industrial fields. Recently, several efforts have been employed in the development of these innovative materials as nanoscale fluorescence (FL) imaging probes. In this context, we describe the synthesis and the functional properties of a novel fluorescent tyrosine (Tyr, Y)-based nanospheres, obtained by heating at 200 °C a solution of the PEGylated tetra-peptide PEG6-Y4. At room temperature, this peptide self-assembles into not fluorescent low ordered water-soluble fibrillary aggregates. After heating, the aggregation of different polyphenolic species generates Y4-based nanospheres able to emit FL into blue, green and red spectral regions, both in solution and at the solid state. The aggregation features of PEG6-Y4 before and after heating were studied using a set of complementary techniques (Fluorescence, CD, FT-IR, Small and Wide-Angle X-ray Scattering and SEM). After a deep investigation of their optoelectronic properties, these nanospheres could be exploited as promising tools for precise biomedicine in advanced nanomedical technologies (local bioimaging, light diagnostics, therapy, optogenetics and health monitoring).
format	article
author	Enrico Gallo Carlo Diaferia Nicole Balasco Teresa Sibillano Valentina Roviello Cinzia Giannini Luigi Vitagliano Giancarlo Morelli Antonella Accardo
author_facet	Enrico Gallo Carlo Diaferia Nicole Balasco Teresa Sibillano Valentina Roviello Cinzia Giannini Luigi Vitagliano Giancarlo Morelli Antonella Accardo
author_sort	Enrico Gallo
title	Fabrication of fluorescent nanospheres by heating PEGylated tetratyrosine nanofibers
title_short	Fabrication of fluorescent nanospheres by heating PEGylated tetratyrosine nanofibers
title_full	Fabrication of fluorescent nanospheres by heating PEGylated tetratyrosine nanofibers
title_fullStr	Fabrication of fluorescent nanospheres by heating PEGylated tetratyrosine nanofibers
title_full_unstemmed	Fabrication of fluorescent nanospheres by heating PEGylated tetratyrosine nanofibers
title_sort	fabrication of fluorescent nanospheres by heating pegylated tetratyrosine nanofibers
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d02abcc8d1c44c5e8780c8f89e6de57b
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Fabrication of fluorescent nanospheres by heating PEGylated tetratyrosine nanofibers

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