α-Catenin levels determine direction of YAP/TAZ response to autophagy perturbation

Autophagy regulates multiple pathways including YAP/TAZ of the Hippo pathway, but precise mechanisms are unclear as autophagy may either activate or inhibit YAP/TAZ. Here, the authors show that autophagy can either activate or regulate YAP/TAZ via dynamic negative feedback loops involving alpha-cate...

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Autores principales:	Mariana Pavel, So Jung Park, Rebecca A. Frake, Sung Min Son, Marco M. Manni, Carla F. Bento, Maurizio Renna, Thomas Ricketts, Fiona M. Menzies, Radu Tanasa, David C. Rubinsztein
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d02b9e5043ae49d9b06eb7b9936822b7
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spelling	oai:doaj.org-article:d02b9e5043ae49d9b06eb7b9936822b72021-12-02T11:39:18Zα-Catenin levels determine direction of YAP/TAZ response to autophagy perturbation10.1038/s41467-021-21882-12041-1723https://doaj.org/article/d02b9e5043ae49d9b06eb7b9936822b72021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21882-1https://doaj.org/toc/2041-1723Autophagy regulates multiple pathways including YAP/TAZ of the Hippo pathway, but precise mechanisms are unclear as autophagy may either activate or inhibit YAP/TAZ. Here, the authors show that autophagy can either activate or regulate YAP/TAZ via dynamic negative feedback loops involving alpha-catenin.Mariana PavelSo Jung ParkRebecca A. FrakeSung Min SonMarco M. ManniCarla F. BentoMaurizio RennaThomas RickettsFiona M. MenziesRadu TanasaDavid C. RubinszteinNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-21 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mariana Pavel So Jung Park Rebecca A. Frake Sung Min Son Marco M. Manni Carla F. Bento Maurizio Renna Thomas Ricketts Fiona M. Menzies Radu Tanasa David C. Rubinsztein α-Catenin levels determine direction of YAP/TAZ response to autophagy perturbation
description	Autophagy regulates multiple pathways including YAP/TAZ of the Hippo pathway, but precise mechanisms are unclear as autophagy may either activate or inhibit YAP/TAZ. Here, the authors show that autophagy can either activate or regulate YAP/TAZ via dynamic negative feedback loops involving alpha-catenin.
format	article
author	Mariana Pavel So Jung Park Rebecca A. Frake Sung Min Son Marco M. Manni Carla F. Bento Maurizio Renna Thomas Ricketts Fiona M. Menzies Radu Tanasa David C. Rubinsztein
author_facet	Mariana Pavel So Jung Park Rebecca A. Frake Sung Min Son Marco M. Manni Carla F. Bento Maurizio Renna Thomas Ricketts Fiona M. Menzies Radu Tanasa David C. Rubinsztein
author_sort	Mariana Pavel
title	α-Catenin levels determine direction of YAP/TAZ response to autophagy perturbation
title_short	α-Catenin levels determine direction of YAP/TAZ response to autophagy perturbation
title_full	α-Catenin levels determine direction of YAP/TAZ response to autophagy perturbation
title_fullStr	α-Catenin levels determine direction of YAP/TAZ response to autophagy perturbation
title_full_unstemmed	α-Catenin levels determine direction of YAP/TAZ response to autophagy perturbation
title_sort	α-catenin levels determine direction of yap/taz response to autophagy perturbation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d02b9e5043ae49d9b06eb7b9936822b7
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α-Catenin levels determine direction of YAP/TAZ response to autophagy perturbation

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