Network theory analysis of antibody-antigen reactivity data: the immune trees at birth and adulthood.

<h4>Motivation</h4>New antigen microarray technology enables parallel recording of antibody reactivities with hundreds of antigens. Such data affords system level analysis of the immune system's organization using methods and approaches from network theory. Here we measured the reac...

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Autores principales:	Asaf Madi, Dror Y Kenett, Sharron Bransburg-Zabary, Yifat Merbl, Francisco J Quintana, Alfred I Tauber, Irun R Cohen, Eshel Ben-Jacob
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d02e048d60d94d74beb936f522038f81
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spelling	oai:doaj.org-article:d02e048d60d94d74beb936f522038f812021-11-18T06:57:37ZNetwork theory analysis of antibody-antigen reactivity data: the immune trees at birth and adulthood.1932-620310.1371/journal.pone.0017445https://doaj.org/article/d02e048d60d94d74beb936f522038f812011-03-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21408156/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Motivation</h4>New antigen microarray technology enables parallel recording of antibody reactivities with hundreds of antigens. Such data affords system level analysis of the immune system's organization using methods and approaches from network theory. Here we measured the reactivity of 290 antigens (for both the IgG and IgM isotypes) of 10 healthy mothers and their term newborns. We constructed antigen correlation networks (or immune networks) whose nodes are the antigens and the edges are the antigen-antigen reactivity correlations, and we also computed their corresponding minimum spanning trees (MST)--maximal information reduced sub-graphs. We quantify the network organization (topology) in terms of the network theory divergence rate measure and rank the antigen importance in the full antigen correlation networks by the eigen-value centrality measure. This analysis makes possible the characterization and comparison of the IgG and IgM immune networks at birth (newborns) and adulthood (mothers) in terms of topology and node importance.<h4>Results</h4>Comparison of the immune network topology at birth and adulthood revealed partial conservation of the IgG immune network topology, and significant reorganization of the IgM immune networks. Inspection of the antigen importance revealed some dominant (in terms of high centrality) antigens in the IgG and IgM networks at birth, which retain their importance at adulthood.Asaf MadiDror Y KenettSharron Bransburg-ZabaryYifat MerblFrancisco J QuintanaAlfred I TauberIrun R CohenEshel Ben-JacobPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 3, p e17445 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Asaf Madi Dror Y Kenett Sharron Bransburg-Zabary Yifat Merbl Francisco J Quintana Alfred I Tauber Irun R Cohen Eshel Ben-Jacob Network theory analysis of antibody-antigen reactivity data: the immune trees at birth and adulthood.
description	<h4>Motivation</h4>New antigen microarray technology enables parallel recording of antibody reactivities with hundreds of antigens. Such data affords system level analysis of the immune system's organization using methods and approaches from network theory. Here we measured the reactivity of 290 antigens (for both the IgG and IgM isotypes) of 10 healthy mothers and their term newborns. We constructed antigen correlation networks (or immune networks) whose nodes are the antigens and the edges are the antigen-antigen reactivity correlations, and we also computed their corresponding minimum spanning trees (MST)--maximal information reduced sub-graphs. We quantify the network organization (topology) in terms of the network theory divergence rate measure and rank the antigen importance in the full antigen correlation networks by the eigen-value centrality measure. This analysis makes possible the characterization and comparison of the IgG and IgM immune networks at birth (newborns) and adulthood (mothers) in terms of topology and node importance.<h4>Results</h4>Comparison of the immune network topology at birth and adulthood revealed partial conservation of the IgG immune network topology, and significant reorganization of the IgM immune networks. Inspection of the antigen importance revealed some dominant (in terms of high centrality) antigens in the IgG and IgM networks at birth, which retain their importance at adulthood.
format	article
author	Asaf Madi Dror Y Kenett Sharron Bransburg-Zabary Yifat Merbl Francisco J Quintana Alfred I Tauber Irun R Cohen Eshel Ben-Jacob
author_facet	Asaf Madi Dror Y Kenett Sharron Bransburg-Zabary Yifat Merbl Francisco J Quintana Alfred I Tauber Irun R Cohen Eshel Ben-Jacob
author_sort	Asaf Madi
title	Network theory analysis of antibody-antigen reactivity data: the immune trees at birth and adulthood.
title_short	Network theory analysis of antibody-antigen reactivity data: the immune trees at birth and adulthood.
title_full	Network theory analysis of antibody-antigen reactivity data: the immune trees at birth and adulthood.
title_fullStr	Network theory analysis of antibody-antigen reactivity data: the immune trees at birth and adulthood.
title_full_unstemmed	Network theory analysis of antibody-antigen reactivity data: the immune trees at birth and adulthood.
title_sort	network theory analysis of antibody-antigen reactivity data: the immune trees at birth and adulthood.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/d02e048d60d94d74beb936f522038f81
work_keys_str_mv	AT asafmadi networktheoryanalysisofantibodyantigenreactivitydatatheimmunetreesatbirthandadulthood AT drorykenett networktheoryanalysisofantibodyantigenreactivitydatatheimmunetreesatbirthandadulthood AT sharronbransburgzabary networktheoryanalysisofantibodyantigenreactivitydatatheimmunetreesatbirthandadulthood AT yifatmerbl networktheoryanalysisofantibodyantigenreactivitydatatheimmunetreesatbirthandadulthood AT franciscojquintana networktheoryanalysisofantibodyantigenreactivitydatatheimmunetreesatbirthandadulthood AT alfreditauber networktheoryanalysisofantibodyantigenreactivitydatatheimmunetreesatbirthandadulthood AT irunrcohen networktheoryanalysisofantibodyantigenreactivitydatatheimmunetreesatbirthandadulthood AT eshelbenjacob networktheoryanalysisofantibodyantigenreactivitydatatheimmunetreesatbirthandadulthood
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Network theory analysis of antibody-antigen reactivity data: the immune trees at birth and adulthood.

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