VISUAL PATTERNS OF С4А AND C4B SUBISOTYPES OF C4 COMPONENT OF HUMAN COMPLEMENT SYSTEM IN THE DIAGNOSTICS OF AUTOIMMUNE AND INFECTIOUS DISEASES

Results on visual patterns of subisotypes of patient sera complement component C4 complexes separated by isoelectric focusing in polyacrylamide gel and eiectrobiotting are presented. Method of visual controlled desialylation of sera using iso types C4A and C4B as internal biomarkers is described. Me...

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Autores principales:	M. V. Lakhtin, V. M. Lakhtin, S. S. Afanasiev, V. A. Aleshkin
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2015
Materias:	complement system isotypes c4a and c4b desialylation of serum autoimmune and infectious diseases diagnostics Science Q
Acceso en línea:	https://doaj.org/article/d02ffdbfef614833b0ec46dae8e02710
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spelling	oai:doaj.org-article:d02ffdbfef614833b0ec46dae8e027102021-11-23T06:14:33ZVISUAL PATTERNS OF С4А AND C4B SUBISOTYPES OF C4 COMPONENT OF HUMAN COMPLEMENT SYSTEM IN THE DIAGNOSTICS OF AUTOIMMUNE AND INFECTIOUS DISEASES2541-94202587-9596https://doaj.org/article/d02ffdbfef614833b0ec46dae8e027102015-09-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/122https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Results on visual patterns of subisotypes of patient sera complement component C4 complexes separated by isoelectric focusing in polyacrylamide gel and eiectrobiotting are presented. Method of visual controlled desialylation of sera using iso types C4A and C4B as internal biomarkers is described. Method was applied to investigation C4 isotyping and subisotyping patient sera. Sera of patients were classified into groups differing in subisotyping. The number of established groups of system component C4 was higher compared to groups detecting by other methods (for example, detecting using microplate functional assay of isotypes C4A and С4В]. Results open new prospects in diagnostics of autoimmune and infectious diseases using detection of pathological blood biomarkers complexed to C4 isotypes.M. V. LakhtinV. M. LakhtinS. S. AfanasievV. A. AleshkinScientific Сentre for Family Health and Human Reproduction Problemsarticlecomplement systemisotypes c4a and c4bdesialylation of serumautoimmune and infectious diseasesdiagnosticsScienceQRUActa Biomedica Scientifica, Vol 0, Iss 5, Pp 88-93 (2015)
institution	DOAJ
collection	DOAJ
language	RU
topic	complement system isotypes c4a and c4b desialylation of serum autoimmune and infectious diseases diagnostics Science Q
spellingShingle	complement system isotypes c4a and c4b desialylation of serum autoimmune and infectious diseases diagnostics Science Q M. V. Lakhtin V. M. Lakhtin S. S. Afanasiev V. A. Aleshkin VISUAL PATTERNS OF С4А AND C4B SUBISOTYPES OF C4 COMPONENT OF HUMAN COMPLEMENT SYSTEM IN THE DIAGNOSTICS OF AUTOIMMUNE AND INFECTIOUS DISEASES
description	Results on visual patterns of subisotypes of patient sera complement component C4 complexes separated by isoelectric focusing in polyacrylamide gel and eiectrobiotting are presented. Method of visual controlled desialylation of sera using iso types C4A and C4B as internal biomarkers is described. Method was applied to investigation C4 isotyping and subisotyping patient sera. Sera of patients were classified into groups differing in subisotyping. The number of established groups of system component C4 was higher compared to groups detecting by other methods (for example, detecting using microplate functional assay of isotypes C4A and С4В]. Results open new prospects in diagnostics of autoimmune and infectious diseases using detection of pathological blood biomarkers complexed to C4 isotypes.
format	article
author	M. V. Lakhtin V. M. Lakhtin S. S. Afanasiev V. A. Aleshkin
author_facet	M. V. Lakhtin V. M. Lakhtin S. S. Afanasiev V. A. Aleshkin
author_sort	M. V. Lakhtin
title	VISUAL PATTERNS OF С4А AND C4B SUBISOTYPES OF C4 COMPONENT OF HUMAN COMPLEMENT SYSTEM IN THE DIAGNOSTICS OF AUTOIMMUNE AND INFECTIOUS DISEASES
title_short	VISUAL PATTERNS OF С4А AND C4B SUBISOTYPES OF C4 COMPONENT OF HUMAN COMPLEMENT SYSTEM IN THE DIAGNOSTICS OF AUTOIMMUNE AND INFECTIOUS DISEASES
title_full	VISUAL PATTERNS OF С4А AND C4B SUBISOTYPES OF C4 COMPONENT OF HUMAN COMPLEMENT SYSTEM IN THE DIAGNOSTICS OF AUTOIMMUNE AND INFECTIOUS DISEASES
title_fullStr	VISUAL PATTERNS OF С4А AND C4B SUBISOTYPES OF C4 COMPONENT OF HUMAN COMPLEMENT SYSTEM IN THE DIAGNOSTICS OF AUTOIMMUNE AND INFECTIOUS DISEASES
title_full_unstemmed	VISUAL PATTERNS OF С4А AND C4B SUBISOTYPES OF C4 COMPONENT OF HUMAN COMPLEMENT SYSTEM IN THE DIAGNOSTICS OF AUTOIMMUNE AND INFECTIOUS DISEASES
title_sort	visual patterns of с4а and c4b subisotypes of c4 component of human complement system in the diagnostics of autoimmune and infectious diseases
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2015
url	https://doaj.org/article/d02ffdbfef614833b0ec46dae8e02710
work_keys_str_mv	AT mvlakhtin visualpatternsofs4aandc4bsubisotypesofc4componentofhumancomplementsysteminthediagnosticsofautoimmuneandinfectiousdiseases AT vmlakhtin visualpatternsofs4aandc4bsubisotypesofc4componentofhumancomplementsysteminthediagnosticsofautoimmuneandinfectiousdiseases AT ssafanasiev visualpatternsofs4aandc4bsubisotypesofc4componentofhumancomplementsysteminthediagnosticsofautoimmuneandinfectiousdiseases AT vaaleshkin visualpatternsofs4aandc4bsubisotypesofc4componentofhumancomplementsysteminthediagnosticsofautoimmuneandinfectiousdiseases
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VISUAL PATTERNS OF С4А AND C4B SUBISOTYPES OF C4 COMPONENT OF HUMAN COMPLEMENT SYSTEM IN THE DIAGNOSTICS OF AUTOIMMUNE AND INFECTIOUS DISEASES

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