Anti-allergic and anti-atopic dermatitis effects of Gardenia Fructus extract

Atopic dermatitis (AD) is a common allergic, inflammatory skin disease. Here, we focused on the anti-allergic and anti-inflammatory effects of Gardenia jasminoides Ellis fructus extracts (GFE) in DNCB treated NC/Nga mice. In an in vivo study, GFE treatment significantly decreased immunoglobulin E (I...

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Autores principales:	Trishna Debnath, Young Min Lee, Ji Hong Lim, Beong Ou Lim
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2018
Materias:	atopic dermatitis gardeniae fruits immunoglobulin e (ige) mast cells Agriculture (General) S1-972 Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/d0302a1c2f5b4ddba8821304dcc0ca64
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spelling	oai:doaj.org-article:d0302a1c2f5b4ddba8821304dcc0ca642021-11-26T11:19:46ZAnti-allergic and anti-atopic dermatitis effects of Gardenia Fructus extract0954-01051465-344310.1080/09540105.2018.1436523https://doaj.org/article/d0302a1c2f5b4ddba8821304dcc0ca642018-01-01T00:00:00Zhttp://dx.doi.org/10.1080/09540105.2018.1436523https://doaj.org/toc/0954-0105https://doaj.org/toc/1465-3443Atopic dermatitis (AD) is a common allergic, inflammatory skin disease. Here, we focused on the anti-allergic and anti-inflammatory effects of Gardenia jasminoides Ellis fructus extracts (GFE) in DNCB treated NC/Nga mice. In an in vivo study, GFE treatment significantly decreased immunoglobulin E (IgE) levels and cytokines expression in spleen and serum of treatment groups mice, compared with the negative controls (administered 0.2% DNCB only). Mice treated with GFE had fewer inflammatory cell infiltrates in the dermis and hypodermis compared to the negative controls. In addition, we also studied β-Hexosaminidase release assay and possible anti-inflammatory mechanism of GFE in RBL-2H3 cells. GFE suppressed the expression of COX-2 and TNF-α, the translocation of NF-κβ, and the phosphorylation of Syk, p38, JNK, and Erk1/2 in stimulated RBL-2H3 cells. These results strongly suggest that GFE inhibits the allergic response by reducing mast cell activation and may have therapeutic potential as an anti-atopic dermatitis agent.Trishna DebnathYoung Min LeeJi Hong LimBeong Ou LimTaylor & Francis Grouparticleatopic dermatitisgardeniae fruitsimmunoglobulin e (ige)mast cellsAgriculture (General)S1-972Immunologic diseases. AllergyRC581-607ENFood and Agricultural Immunology, Vol 29, Iss 1, Pp 665-674 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	atopic dermatitis gardeniae fruits immunoglobulin e (ige) mast cells Agriculture (General) S1-972 Immunologic diseases. Allergy RC581-607
spellingShingle	atopic dermatitis gardeniae fruits immunoglobulin e (ige) mast cells Agriculture (General) S1-972 Immunologic diseases. Allergy RC581-607 Trishna Debnath Young Min Lee Ji Hong Lim Beong Ou Lim Anti-allergic and anti-atopic dermatitis effects of Gardenia Fructus extract
description	Atopic dermatitis (AD) is a common allergic, inflammatory skin disease. Here, we focused on the anti-allergic and anti-inflammatory effects of Gardenia jasminoides Ellis fructus extracts (GFE) in DNCB treated NC/Nga mice. In an in vivo study, GFE treatment significantly decreased immunoglobulin E (IgE) levels and cytokines expression in spleen and serum of treatment groups mice, compared with the negative controls (administered 0.2% DNCB only). Mice treated with GFE had fewer inflammatory cell infiltrates in the dermis and hypodermis compared to the negative controls. In addition, we also studied β-Hexosaminidase release assay and possible anti-inflammatory mechanism of GFE in RBL-2H3 cells. GFE suppressed the expression of COX-2 and TNF-α, the translocation of NF-κβ, and the phosphorylation of Syk, p38, JNK, and Erk1/2 in stimulated RBL-2H3 cells. These results strongly suggest that GFE inhibits the allergic response by reducing mast cell activation and may have therapeutic potential as an anti-atopic dermatitis agent.
format	article
author	Trishna Debnath Young Min Lee Ji Hong Lim Beong Ou Lim
author_facet	Trishna Debnath Young Min Lee Ji Hong Lim Beong Ou Lim
author_sort	Trishna Debnath
title	Anti-allergic and anti-atopic dermatitis effects of Gardenia Fructus extract
title_short	Anti-allergic and anti-atopic dermatitis effects of Gardenia Fructus extract
title_full	Anti-allergic and anti-atopic dermatitis effects of Gardenia Fructus extract
title_fullStr	Anti-allergic and anti-atopic dermatitis effects of Gardenia Fructus extract
title_full_unstemmed	Anti-allergic and anti-atopic dermatitis effects of Gardenia Fructus extract
title_sort	anti-allergic and anti-atopic dermatitis effects of gardenia fructus extract
publisher	Taylor & Francis Group
publishDate	2018
url	https://doaj.org/article/d0302a1c2f5b4ddba8821304dcc0ca64
work_keys_str_mv	AT trishnadebnath antiallergicandantiatopicdermatitiseffectsofgardeniafructusextract AT youngminlee antiallergicandantiatopicdermatitiseffectsofgardeniafructusextract AT jihonglim antiallergicandantiatopicdermatitiseffectsofgardeniafructusextract AT beongoulim antiallergicandantiatopicdermatitiseffectsofgardeniafructusextract
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Anti-allergic and anti-atopic dermatitis effects of Gardenia Fructus extract

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