Mitochondrial Dynamic Dysfunction as a Main Triggering Factor for Inflammation Associated Chronic Non-Communicable Diseases

Zeleke Geto,1 Meseret Derbew Molla,2 Feyissa Challa,1 Yohannes Belay,3 Tigist Getahun1 1National Reference Laboratory for Clinical Chemistry, Ethiopian Public Health Institute, Addis Ababa, Ethiopia; 2Department of Biochemistry, School of Medicine, College of Medicine and Health Sciences, University...

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Autores principales:	Geto Z, Molla MD, Challa F, Belay Y, Getahun T
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	mitochondria dynamics inflammation non communicable diseases Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/d034cd6730ed4a4ca380144992bdc890
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spelling	oai:doaj.org-article:d034cd6730ed4a4ca380144992bdc8902021-12-02T12:07:37ZMitochondrial Dynamic Dysfunction as a Main Triggering Factor for Inflammation Associated Chronic Non-Communicable Diseases1178-7031https://doaj.org/article/d034cd6730ed4a4ca380144992bdc8902020-02-01T00:00:00Zhttps://www.dovepress.com/mitochondrial-dynamic-dysfunction-as-a-main-triggering-factor-for-infl-peer-reviewed-article-JIRhttps://doaj.org/toc/1178-7031Zeleke Geto,1 Meseret Derbew Molla,2 Feyissa Challa,1 Yohannes Belay,3 Tigist Getahun1 1National Reference Laboratory for Clinical Chemistry, Ethiopian Public Health Institute, Addis Ababa, Ethiopia; 2Department of Biochemistry, School of Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia; 3National Reference Laboratory for Hematology and Immunology, Ethiopian Public Health Institute, Addis Ababa, EthiopiaCorrespondence: Zeleke Geto Email zegetdm@gmail.comAbstract: Mitochondria are organelles with highly dynamic ultrastructure maintained by flexible fusion and fission rates governed by Guanosine Triphosphatases (GTPases) dependent proteins. Balanced control of mitochondrial quality control is crucial for maintaining cellular energy and metabolic homeostasis; however, dysfunction of the dynamics of fusion and fission causes loss of integrity and functions with the accumulation of damaged mitochondria and mitochondrial deoxyribose nucleic acid (mtDNA) that can halt energy production and induce oxidative stress. Mitochondrial derived reactive oxygen species (ROS) can mediate redox signaling or, in excess, causing activation of inflammatory proteins and further exacerbate mitochondrial deterioration and oxidative stress. ROS have a deleterious effect on many cellular components, including lipids, proteins, both nuclear and mtDNA and cell membrane lipids producing the net result of the accumulation of damage associated molecular pattern (DAMPs) capable of activating pathogen recognition receptors (PRRs) on the surface and in the cytoplasm of immune cells. Chronic inflammation due to oxidative damage is thought to trigger numerous chronic diseases including cardiac, liver and kidney disorders, neurodegenerative diseases (Parkinson’s disease and Alzheimer’s disease), cardiovascular diseases/atherosclerosis, obesity, insulin resistance, and type 2 diabetes mellitus.Keywords: mitochondria, dynamics, inflammation, non-communicable diseasesGeto ZMolla MDChalla FBelay YGetahun TDove Medical Pressarticlemitochondriadynamicsinflammationnon communicable diseasesPathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 13, Pp 97-107 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	mitochondria dynamics inflammation non communicable diseases Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	mitochondria dynamics inflammation non communicable diseases Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Geto Z Molla MD Challa F Belay Y Getahun T Mitochondrial Dynamic Dysfunction as a Main Triggering Factor for Inflammation Associated Chronic Non-Communicable Diseases
description	Zeleke Geto,1 Meseret Derbew Molla,2 Feyissa Challa,1 Yohannes Belay,3 Tigist Getahun1 1National Reference Laboratory for Clinical Chemistry, Ethiopian Public Health Institute, Addis Ababa, Ethiopia; 2Department of Biochemistry, School of Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia; 3National Reference Laboratory for Hematology and Immunology, Ethiopian Public Health Institute, Addis Ababa, EthiopiaCorrespondence: Zeleke Geto Email zegetdm@gmail.comAbstract: Mitochondria are organelles with highly dynamic ultrastructure maintained by flexible fusion and fission rates governed by Guanosine Triphosphatases (GTPases) dependent proteins. Balanced control of mitochondrial quality control is crucial for maintaining cellular energy and metabolic homeostasis; however, dysfunction of the dynamics of fusion and fission causes loss of integrity and functions with the accumulation of damaged mitochondria and mitochondrial deoxyribose nucleic acid (mtDNA) that can halt energy production and induce oxidative stress. Mitochondrial derived reactive oxygen species (ROS) can mediate redox signaling or, in excess, causing activation of inflammatory proteins and further exacerbate mitochondrial deterioration and oxidative stress. ROS have a deleterious effect on many cellular components, including lipids, proteins, both nuclear and mtDNA and cell membrane lipids producing the net result of the accumulation of damage associated molecular pattern (DAMPs) capable of activating pathogen recognition receptors (PRRs) on the surface and in the cytoplasm of immune cells. Chronic inflammation due to oxidative damage is thought to trigger numerous chronic diseases including cardiac, liver and kidney disorders, neurodegenerative diseases (Parkinson’s disease and Alzheimer’s disease), cardiovascular diseases/atherosclerosis, obesity, insulin resistance, and type 2 diabetes mellitus.Keywords: mitochondria, dynamics, inflammation, non-communicable diseases
format	article
author	Geto Z Molla MD Challa F Belay Y Getahun T
author_facet	Geto Z Molla MD Challa F Belay Y Getahun T
author_sort	Geto Z
title	Mitochondrial Dynamic Dysfunction as a Main Triggering Factor for Inflammation Associated Chronic Non-Communicable Diseases
title_short	Mitochondrial Dynamic Dysfunction as a Main Triggering Factor for Inflammation Associated Chronic Non-Communicable Diseases
title_full	Mitochondrial Dynamic Dysfunction as a Main Triggering Factor for Inflammation Associated Chronic Non-Communicable Diseases
title_fullStr	Mitochondrial Dynamic Dysfunction as a Main Triggering Factor for Inflammation Associated Chronic Non-Communicable Diseases
title_full_unstemmed	Mitochondrial Dynamic Dysfunction as a Main Triggering Factor for Inflammation Associated Chronic Non-Communicable Diseases
title_sort	mitochondrial dynamic dysfunction as a main triggering factor for inflammation associated chronic non-communicable diseases
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/d034cd6730ed4a4ca380144992bdc890
work_keys_str_mv	AT getoz mitochondrialdynamicdysfunctionasamaintriggeringfactorforinflammationassociatedchronicnoncommunicablediseases AT mollamd mitochondrialdynamicdysfunctionasamaintriggeringfactorforinflammationassociatedchronicnoncommunicablediseases AT challaf mitochondrialdynamicdysfunctionasamaintriggeringfactorforinflammationassociatedchronicnoncommunicablediseases AT belayy mitochondrialdynamicdysfunctionasamaintriggeringfactorforinflammationassociatedchronicnoncommunicablediseases AT getahunt mitochondrialdynamicdysfunctionasamaintriggeringfactorforinflammationassociatedchronicnoncommunicablediseases
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Mitochondrial Dynamic Dysfunction as a Main Triggering Factor for Inflammation Associated Chronic Non-Communicable Diseases

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