Patterned human microvascular grafts enable rapid vascularization and increase perfusion in infarcted rat hearts

Heart grafts need good vascularization to survive. Here, the authors engineer perfusable constructs of human embryonic stem cell-derived endothelial cells seeded in collagen matrix in patterned microchannels that form anastomosed vessels in vitro and have increased coronary vascular perfusion on tra...

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Autores principales:	Meredith A. Redd, Nicole Zeinstra, Wan Qin, Wei Wei, Amy Martinson, Yuliang Wang, Ruikang K. Wang, Charles E. Murry, Ying Zheng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d0353d4f8b0744d1a71917d43e8a02a6
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spelling	oai:doaj.org-article:d0353d4f8b0744d1a71917d43e8a02a62021-12-02T16:57:07ZPatterned human microvascular grafts enable rapid vascularization and increase perfusion in infarcted rat hearts10.1038/s41467-019-08388-72041-1723https://doaj.org/article/d0353d4f8b0744d1a71917d43e8a02a62019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08388-7https://doaj.org/toc/2041-1723Heart grafts need good vascularization to survive. Here, the authors engineer perfusable constructs of human embryonic stem cell-derived endothelial cells seeded in collagen matrix in patterned microchannels that form anastomosed vessels in vitro and have increased coronary vascular perfusion on transplantation in rats.Meredith A. ReddNicole ZeinstraWan QinWei WeiAmy MartinsonYuliang WangRuikang K. WangCharles E. MurryYing ZhengNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Meredith A. Redd Nicole Zeinstra Wan Qin Wei Wei Amy Martinson Yuliang Wang Ruikang K. Wang Charles E. Murry Ying Zheng Patterned human microvascular grafts enable rapid vascularization and increase perfusion in infarcted rat hearts
description	Heart grafts need good vascularization to survive. Here, the authors engineer perfusable constructs of human embryonic stem cell-derived endothelial cells seeded in collagen matrix in patterned microchannels that form anastomosed vessels in vitro and have increased coronary vascular perfusion on transplantation in rats.
format	article
author	Meredith A. Redd Nicole Zeinstra Wan Qin Wei Wei Amy Martinson Yuliang Wang Ruikang K. Wang Charles E. Murry Ying Zheng
author_facet	Meredith A. Redd Nicole Zeinstra Wan Qin Wei Wei Amy Martinson Yuliang Wang Ruikang K. Wang Charles E. Murry Ying Zheng
author_sort	Meredith A. Redd
title	Patterned human microvascular grafts enable rapid vascularization and increase perfusion in infarcted rat hearts
title_short	Patterned human microvascular grafts enable rapid vascularization and increase perfusion in infarcted rat hearts
title_full	Patterned human microvascular grafts enable rapid vascularization and increase perfusion in infarcted rat hearts
title_fullStr	Patterned human microvascular grafts enable rapid vascularization and increase perfusion in infarcted rat hearts
title_full_unstemmed	Patterned human microvascular grafts enable rapid vascularization and increase perfusion in infarcted rat hearts
title_sort	patterned human microvascular grafts enable rapid vascularization and increase perfusion in infarcted rat hearts
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/d0353d4f8b0744d1a71917d43e8a02a6
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Patterned human microvascular grafts enable rapid vascularization and increase perfusion in infarcted rat hearts

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