Analysis on the healing of gastrointestinal ulceration by using Hemospray

Abstract Healing of gastrointestinal ulcers after Hemospray application was reported in literature. The pathophysiological mechanism of action of hemostatic powders is not elucidated so far. A prospective animal model was performed to evaluate the effect of Hemospray application on the healing proce...

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Autores principales:	Christoph R. Werner, Lena Brücklmeier, Thomas Kratt, Nisar P. Malek, Bence Sipos, Dörte Wichmann, Martin Götz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d0354860fb0f4c2e9269c6738c537a08
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spelling	oai:doaj.org-article:d0354860fb0f4c2e9269c6738c537a082021-12-02T17:27:11ZAnalysis on the healing of gastrointestinal ulceration by using Hemospray10.1038/s41598-021-98664-82045-2322https://doaj.org/article/d0354860fb0f4c2e9269c6738c537a082021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98664-8https://doaj.org/toc/2045-2322Abstract Healing of gastrointestinal ulcers after Hemospray application was reported in literature. The pathophysiological mechanism of action of hemostatic powders is not elucidated so far. A prospective animal model was performed to evaluate the effect of Hemospray application on the healing process of artificially induced ulcers of the upper and lower gastrointestinal tract. In 10 pigs, 20 ulcers were created in each the upper and the lower gastrointestinal tract by endoscopic mucosal resection. 50% of the pigs were immediately treated with Hemospray application, the others were not treated. Ulcer size was measured endoscopically on day 0, 2, and 7. On day 7 the ulcers were histopathological evaluated for capillary ingrowth and the thickness of the collagen layer. After 7 days the sizes of the ulcers decreased significantly (stomach: − 22.8% with Hemospray application, − 19% without Hemospray application; rectum: − 50.8% with Hemospray application, − 49.5% without Hemospray application; p = 0.005–0.037), but without significant difference between both groups. This study shows no significant effect of the hemostatic powder Hemospray on ulcer healing in the upper and lower gastrointestinal tract compared with untreated controls, neither harmful nor beneficial. However, some trends merit further trials in patients and may indicate a possible mechanism of accelerated mucosal healing.Christoph R. WernerLena BrücklmeierThomas KrattNisar P. MalekBence SiposDörte WichmannMartin GötzNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Christoph R. Werner Lena Brücklmeier Thomas Kratt Nisar P. Malek Bence Sipos Dörte Wichmann Martin Götz Analysis on the healing of gastrointestinal ulceration by using Hemospray
description	Abstract Healing of gastrointestinal ulcers after Hemospray application was reported in literature. The pathophysiological mechanism of action of hemostatic powders is not elucidated so far. A prospective animal model was performed to evaluate the effect of Hemospray application on the healing process of artificially induced ulcers of the upper and lower gastrointestinal tract. In 10 pigs, 20 ulcers were created in each the upper and the lower gastrointestinal tract by endoscopic mucosal resection. 50% of the pigs were immediately treated with Hemospray application, the others were not treated. Ulcer size was measured endoscopically on day 0, 2, and 7. On day 7 the ulcers were histopathological evaluated for capillary ingrowth and the thickness of the collagen layer. After 7 days the sizes of the ulcers decreased significantly (stomach: − 22.8% with Hemospray application, − 19% without Hemospray application; rectum: − 50.8% with Hemospray application, − 49.5% without Hemospray application; p = 0.005–0.037), but without significant difference between both groups. This study shows no significant effect of the hemostatic powder Hemospray on ulcer healing in the upper and lower gastrointestinal tract compared with untreated controls, neither harmful nor beneficial. However, some trends merit further trials in patients and may indicate a possible mechanism of accelerated mucosal healing.
format	article
author	Christoph R. Werner Lena Brücklmeier Thomas Kratt Nisar P. Malek Bence Sipos Dörte Wichmann Martin Götz
author_facet	Christoph R. Werner Lena Brücklmeier Thomas Kratt Nisar P. Malek Bence Sipos Dörte Wichmann Martin Götz
author_sort	Christoph R. Werner
title	Analysis on the healing of gastrointestinal ulceration by using Hemospray
title_short	Analysis on the healing of gastrointestinal ulceration by using Hemospray
title_full	Analysis on the healing of gastrointestinal ulceration by using Hemospray
title_fullStr	Analysis on the healing of gastrointestinal ulceration by using Hemospray
title_full_unstemmed	Analysis on the healing of gastrointestinal ulceration by using Hemospray
title_sort	analysis on the healing of gastrointestinal ulceration by using hemospray
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d0354860fb0f4c2e9269c6738c537a08
work_keys_str_mv	AT christophrwerner analysisonthehealingofgastrointestinalulcerationbyusinghemospray AT lenabrucklmeier analysisonthehealingofgastrointestinalulcerationbyusinghemospray AT thomaskratt analysisonthehealingofgastrointestinalulcerationbyusinghemospray AT nisarpmalek analysisonthehealingofgastrointestinalulcerationbyusinghemospray AT bencesipos analysisonthehealingofgastrointestinalulcerationbyusinghemospray AT dortewichmann analysisonthehealingofgastrointestinalulcerationbyusinghemospray AT martingotz analysisonthehealingofgastrointestinalulcerationbyusinghemospray
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Analysis on the healing of gastrointestinal ulceration by using Hemospray

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