XanoMatrix surfaces as scaffolds for mesenchymal stem cell culture and growth

Garima Bhardwaj,1 Thomas J Webster1,2 1Department of Chemical Engineering, Northeastern University, Boston, MA, USA; 2Center of Excellence for Advanced Materials Research, King Abdulaziz University, Jeddah, Saudi Arabia Abstract: Stem cells are being widely investigated for a wide variety of appli...

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Autores principales:	Bhardwaj G, Webster TJ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Stem cells cell culture inserts tissue engineering nanofibrous matrices Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/d0356d24f4e24277a5676757eb4310d5
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spelling	oai:doaj.org-article:d0356d24f4e24277a5676757eb4310d52021-12-02T03:58:36ZXanoMatrix surfaces as scaffolds for mesenchymal stem cell culture and growth1178-2013https://doaj.org/article/d0356d24f4e24277a5676757eb4310d52016-06-01T00:00:00Zhttps://www.dovepress.com/xanomatrix-surfaces-as-scaffolds-for-mesenchymal-stem-cell-culture-and-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Garima Bhardwaj,1 Thomas J Webster1,2 1Department of Chemical Engineering, Northeastern University, Boston, MA, USA; 2Center of Excellence for Advanced Materials Research, King Abdulaziz University, Jeddah, Saudi Arabia Abstract: Stem cells are being widely investigated for a wide variety of applications in tissue engineering due to their ability to differentiate into a number of cells such as neurons, osteoblasts, and fibroblasts. This ability of stem cells to differentiate into different types of cells is greatly based on mechanical and chemical cues received from their three-dimensional environments. All organs are formed by a number of cells linked together via an extracellular matrix (ECM). The ECM is a complex network of proteins and carbohydrates, which occupies intercellular spaces and regulates cellular activity by controlling cell adhesion, migration, proliferation, and differentiation. The ECM is composed of two main types of macromolecules, namely, polysaccharide glycosaminoglycans, which are covalently attached to proteins in the form of proteoglycans and fibrous proteins belonging to two functional groups, structural (collagen and elastin) and adhesive (fibronectin, laminin, vitronectin, etc). Tissue engineering is a multidisciplinary field that aims to develop biomimetic scaffolds that emulate properties of the ECM to help repair or regenerate diseased or damaged tissue. This study introduces one of these matrices, XanoMatrix, as an optimal scaffold for tissue engineering applications, in particular, for stem cell research, based on its composition, nanofibrous structure, and porosity. Results of this study suggest that XanoMatrix scaffolds are promising for stem cell tissue engineering applications and as improved cell culture inserts for studying stem cell functions (compared to traditional Corning and Falcon cell culture plates) and, thus, should be further studied. Keywords: stem cells, cell culture inserts, tissue engineering, nanofibrous matricesBhardwaj GWebster TJDove Medical PressarticleStem cellscell culture insertstissue engineeringnanofibrous matricesMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2016, Iss default, Pp 2655-2661 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Stem cells cell culture inserts tissue engineering nanofibrous matrices Medicine (General) R5-920
spellingShingle	Stem cells cell culture inserts tissue engineering nanofibrous matrices Medicine (General) R5-920 Bhardwaj G Webster TJ XanoMatrix surfaces as scaffolds for mesenchymal stem cell culture and growth
description	Garima Bhardwaj,1 Thomas J Webster1,2 1Department of Chemical Engineering, Northeastern University, Boston, MA, USA; 2Center of Excellence for Advanced Materials Research, King Abdulaziz University, Jeddah, Saudi Arabia Abstract: Stem cells are being widely investigated for a wide variety of applications in tissue engineering due to their ability to differentiate into a number of cells such as neurons, osteoblasts, and fibroblasts. This ability of stem cells to differentiate into different types of cells is greatly based on mechanical and chemical cues received from their three-dimensional environments. All organs are formed by a number of cells linked together via an extracellular matrix (ECM). The ECM is a complex network of proteins and carbohydrates, which occupies intercellular spaces and regulates cellular activity by controlling cell adhesion, migration, proliferation, and differentiation. The ECM is composed of two main types of macromolecules, namely, polysaccharide glycosaminoglycans, which are covalently attached to proteins in the form of proteoglycans and fibrous proteins belonging to two functional groups, structural (collagen and elastin) and adhesive (fibronectin, laminin, vitronectin, etc). Tissue engineering is a multidisciplinary field that aims to develop biomimetic scaffolds that emulate properties of the ECM to help repair or regenerate diseased or damaged tissue. This study introduces one of these matrices, XanoMatrix, as an optimal scaffold for tissue engineering applications, in particular, for stem cell research, based on its composition, nanofibrous structure, and porosity. Results of this study suggest that XanoMatrix scaffolds are promising for stem cell tissue engineering applications and as improved cell culture inserts for studying stem cell functions (compared to traditional Corning and Falcon cell culture plates) and, thus, should be further studied. Keywords: stem cells, cell culture inserts, tissue engineering, nanofibrous matrices
format	article
author	Bhardwaj G Webster TJ
author_facet	Bhardwaj G Webster TJ
author_sort	Bhardwaj G
title	XanoMatrix surfaces as scaffolds for mesenchymal stem cell culture and growth
title_short	XanoMatrix surfaces as scaffolds for mesenchymal stem cell culture and growth
title_full	XanoMatrix surfaces as scaffolds for mesenchymal stem cell culture and growth
title_fullStr	XanoMatrix surfaces as scaffolds for mesenchymal stem cell culture and growth
title_full_unstemmed	XanoMatrix surfaces as scaffolds for mesenchymal stem cell culture and growth
title_sort	xanomatrix surfaces as scaffolds for mesenchymal stem cell culture and growth
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/d0356d24f4e24277a5676757eb4310d5
work_keys_str_mv	AT bhardwajg xanomatrixsurfacesasscaffoldsformesenchymalstemcellcultureandgrowth AT webstertj xanomatrixsurfacesasscaffoldsformesenchymalstemcellcultureandgrowth
_version_	1718401519717449728

XanoMatrix surfaces as scaffolds for mesenchymal stem cell culture and growth

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