Analysis of Corneal Spherical Aberrations in Chinese Bilateral Ectopia Lentis Patients

Purpose: To analyze the anterior, posterior, and total corneal spherical aberrations (ASA, PSA, and TSA) in patients with Chinese bilateral ectopia lentis (EL).Methods: A cross-sectional study was conducted to evaluate corneal spherical aberration (CSA) using a Pentacam system at the 6-mm optical zo...

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Autores principales:	Jiahui Chen, Yating Tang, Qinghe Jing, Yi Lu, Yongxiang Jiang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	corneal spherical aberration ectopia lentis Marfan syndrome corneal asphericity aging Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/d03b08a8f81446f3b21031487c33e147
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spelling	oai:doaj.org-article:d03b08a8f81446f3b21031487c33e1472021-11-19T04:48:10ZAnalysis of Corneal Spherical Aberrations in Chinese Bilateral Ectopia Lentis Patients2296-858X10.3389/fmed.2021.736686https://doaj.org/article/d03b08a8f81446f3b21031487c33e1472021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmed.2021.736686/fullhttps://doaj.org/toc/2296-858XPurpose: To analyze the anterior, posterior, and total corneal spherical aberrations (ASA, PSA, and TSA) in patients with Chinese bilateral ectopia lentis (EL).Methods: A cross-sectional study was conducted to evaluate corneal spherical aberration (CSA) using a Pentacam system at the 6-mm optical zone. Axial length, keratometry, astigmatism, and corneal asphericity were also determined.Results: This study included 247 patients (420 eyes) with a mean age of 18.1 years. The values of ASA, PSA, and TSA were 0.136 ± 0.100 μm, −0.118 ± 0.030 μm, and 0.095 ± 0.095 μm, respectively. In the EL patients with Marfan syndrome (MFS), ASA and TSA were significantly lower than in the non-MFS patients (0.126 ± 0.094 μm vs. 0.155 ± 0.107 μm, P = 0.004 for ASA; 0.085 ± 0.091 μm vs. 0.114 ± 0.099 μm, P = 0.003 for TSA), whereas PSA was not significantly different (P = 0.061). The values of ASA and TSA were significantly higher in the patients with EL aged ≥ 40 years old than in younger patients, whereas ASA and PSA were lower in patients aged <10 years old than in older patients (all P < 0.05). In the multiple linear regression analysis, age, keratometry, astigmatism, anterior asphericity, higher-order aberration (HOA), and lower-order aberration (LOA) were positively or negatively correlated with TSA in the patients with EL (r = 0.681, P < 0.001).Conclusions: Corneal spherical aberration was low in the patients with EL especially for MFS and tended to increase with aging. Preoperatively, individual measurement of CSA was necessary for bilateral EL patients with MFS.Jiahui ChenJiahui ChenJiahui ChenYating TangYating TangYating TangQinghe JingQinghe JingQinghe JingYi LuYi LuYi LuYongxiang JiangYongxiang JiangYongxiang JiangFrontiers Media S.A.articlecorneal spherical aberrationectopia lentisMarfan syndromecorneal asphericityagingMedicine (General)R5-920ENFrontiers in Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	corneal spherical aberration ectopia lentis Marfan syndrome corneal asphericity aging Medicine (General) R5-920
spellingShingle	corneal spherical aberration ectopia lentis Marfan syndrome corneal asphericity aging Medicine (General) R5-920 Jiahui Chen Jiahui Chen Jiahui Chen Yating Tang Yating Tang Yating Tang Qinghe Jing Qinghe Jing Qinghe Jing Yi Lu Yi Lu Yi Lu Yongxiang Jiang Yongxiang Jiang Yongxiang Jiang Analysis of Corneal Spherical Aberrations in Chinese Bilateral Ectopia Lentis Patients
description	Purpose: To analyze the anterior, posterior, and total corneal spherical aberrations (ASA, PSA, and TSA) in patients with Chinese bilateral ectopia lentis (EL).Methods: A cross-sectional study was conducted to evaluate corneal spherical aberration (CSA) using a Pentacam system at the 6-mm optical zone. Axial length, keratometry, astigmatism, and corneal asphericity were also determined.Results: This study included 247 patients (420 eyes) with a mean age of 18.1 years. The values of ASA, PSA, and TSA were 0.136 ± 0.100 μm, −0.118 ± 0.030 μm, and 0.095 ± 0.095 μm, respectively. In the EL patients with Marfan syndrome (MFS), ASA and TSA were significantly lower than in the non-MFS patients (0.126 ± 0.094 μm vs. 0.155 ± 0.107 μm, P = 0.004 for ASA; 0.085 ± 0.091 μm vs. 0.114 ± 0.099 μm, P = 0.003 for TSA), whereas PSA was not significantly different (P = 0.061). The values of ASA and TSA were significantly higher in the patients with EL aged ≥ 40 years old than in younger patients, whereas ASA and PSA were lower in patients aged <10 years old than in older patients (all P < 0.05). In the multiple linear regression analysis, age, keratometry, astigmatism, anterior asphericity, higher-order aberration (HOA), and lower-order aberration (LOA) were positively or negatively correlated with TSA in the patients with EL (r = 0.681, P < 0.001).Conclusions: Corneal spherical aberration was low in the patients with EL especially for MFS and tended to increase with aging. Preoperatively, individual measurement of CSA was necessary for bilateral EL patients with MFS.
format	article
author	Jiahui Chen Jiahui Chen Jiahui Chen Yating Tang Yating Tang Yating Tang Qinghe Jing Qinghe Jing Qinghe Jing Yi Lu Yi Lu Yi Lu Yongxiang Jiang Yongxiang Jiang Yongxiang Jiang
author_facet	Jiahui Chen Jiahui Chen Jiahui Chen Yating Tang Yating Tang Yating Tang Qinghe Jing Qinghe Jing Qinghe Jing Yi Lu Yi Lu Yi Lu Yongxiang Jiang Yongxiang Jiang Yongxiang Jiang
author_sort	Jiahui Chen
title	Analysis of Corneal Spherical Aberrations in Chinese Bilateral Ectopia Lentis Patients
title_short	Analysis of Corneal Spherical Aberrations in Chinese Bilateral Ectopia Lentis Patients
title_full	Analysis of Corneal Spherical Aberrations in Chinese Bilateral Ectopia Lentis Patients
title_fullStr	Analysis of Corneal Spherical Aberrations in Chinese Bilateral Ectopia Lentis Patients
title_full_unstemmed	Analysis of Corneal Spherical Aberrations in Chinese Bilateral Ectopia Lentis Patients
title_sort	analysis of corneal spherical aberrations in chinese bilateral ectopia lentis patients
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/d03b08a8f81446f3b21031487c33e147
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Analysis of Corneal Spherical Aberrations in Chinese Bilateral Ectopia Lentis Patients

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