Gsta4 controls apoptosis of differentiating adult oligodendrocytes during homeostasis and remyelination via the mitochondria-associated Fas-Casp8-Bid-axis

Impaired oligodendrocyte (OL) differentiation and remyelination after myelin damage in multiple sclerosis is associated with neurodegeneration. The authors show that Gsta4 is expressed during adult OL differentiation and identify it as a regulator of OL differentiation, survival, and remyelination.

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Autores principales:	Karl E. Carlström, Keying Zhu, Ewoud Ewing, Inge E. Krabbendam, Robert A. Harris, Ana Mendanha Falcão, Maja Jagodic, Gonçalo Castelo-Branco, Fredrik Piehl
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d03fd8239ac14bdc85b1c9c4528105b4
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spelling	oai:doaj.org-article:d03fd8239ac14bdc85b1c9c4528105b42021-12-02T16:43:39ZGsta4 controls apoptosis of differentiating adult oligodendrocytes during homeostasis and remyelination via the mitochondria-associated Fas-Casp8-Bid-axis10.1038/s41467-020-17871-52041-1723https://doaj.org/article/d03fd8239ac14bdc85b1c9c4528105b42020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17871-5https://doaj.org/toc/2041-1723Impaired oligodendrocyte (OL) differentiation and remyelination after myelin damage in multiple sclerosis is associated with neurodegeneration. The authors show that Gsta4 is expressed during adult OL differentiation and identify it as a regulator of OL differentiation, survival, and remyelination.Karl E. CarlströmKeying ZhuEwoud EwingInge E. KrabbendamRobert A. HarrisAna Mendanha FalcãoMaja JagodicGonçalo Castelo-BrancoFredrik PiehlNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Karl E. Carlström Keying Zhu Ewoud Ewing Inge E. Krabbendam Robert A. Harris Ana Mendanha Falcão Maja Jagodic Gonçalo Castelo-Branco Fredrik Piehl Gsta4 controls apoptosis of differentiating adult oligodendrocytes during homeostasis and remyelination via the mitochondria-associated Fas-Casp8-Bid-axis
description	Impaired oligodendrocyte (OL) differentiation and remyelination after myelin damage in multiple sclerosis is associated with neurodegeneration. The authors show that Gsta4 is expressed during adult OL differentiation and identify it as a regulator of OL differentiation, survival, and remyelination.
format	article
author	Karl E. Carlström Keying Zhu Ewoud Ewing Inge E. Krabbendam Robert A. Harris Ana Mendanha Falcão Maja Jagodic Gonçalo Castelo-Branco Fredrik Piehl
author_facet	Karl E. Carlström Keying Zhu Ewoud Ewing Inge E. Krabbendam Robert A. Harris Ana Mendanha Falcão Maja Jagodic Gonçalo Castelo-Branco Fredrik Piehl
author_sort	Karl E. Carlström
title	Gsta4 controls apoptosis of differentiating adult oligodendrocytes during homeostasis and remyelination via the mitochondria-associated Fas-Casp8-Bid-axis
title_short	Gsta4 controls apoptosis of differentiating adult oligodendrocytes during homeostasis and remyelination via the mitochondria-associated Fas-Casp8-Bid-axis
title_full	Gsta4 controls apoptosis of differentiating adult oligodendrocytes during homeostasis and remyelination via the mitochondria-associated Fas-Casp8-Bid-axis
title_fullStr	Gsta4 controls apoptosis of differentiating adult oligodendrocytes during homeostasis and remyelination via the mitochondria-associated Fas-Casp8-Bid-axis
title_full_unstemmed	Gsta4 controls apoptosis of differentiating adult oligodendrocytes during homeostasis and remyelination via the mitochondria-associated Fas-Casp8-Bid-axis
title_sort	gsta4 controls apoptosis of differentiating adult oligodendrocytes during homeostasis and remyelination via the mitochondria-associated fas-casp8-bid-axis
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/d03fd8239ac14bdc85b1c9c4528105b4
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Gsta4 controls apoptosis of differentiating adult oligodendrocytes during homeostasis and remyelination via the mitochondria-associated Fas-Casp8-Bid-axis

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