Surgical treatment for synchronous multiple primary lung cancer: Is it possible to achieve both curability and preservation of the pulmonary function?

Abstract Background With the advent of high‐resolution chest imaging, the number of patients diagnosed with multiple primary lung cancers is increasing. For the treatment of multiple lung cancers, a surgical procedure that preserves pulmonary function while ensuring curability is required. Methods T...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Takuya Watanabe, Masayuki Tanahashi, Eriko Suzuki, Naoko Yoshii, Hiroyuki Tsuchida, Shogo Yobita, Kensuke Iguchi, Suiha Uchiyama, Minori Nakamura
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	limited resection non‐small cell lung cancer pulmonary function surgery synchronous multiple lung cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/d04224d8b9cf4f0383cdb3690f8687b0
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d04224d8b9cf4f0383cdb3690f8687b0
record_format	dspace
spelling	oai:doaj.org-article:d04224d8b9cf4f0383cdb3690f8687b02021-11-14T23:28:25ZSurgical treatment for synchronous multiple primary lung cancer: Is it possible to achieve both curability and preservation of the pulmonary function?1759-77141759-770610.1111/1759-7714.14164https://doaj.org/article/d04224d8b9cf4f0383cdb3690f8687b02021-11-01T00:00:00Zhttps://doi.org/10.1111/1759-7714.14164https://doaj.org/toc/1759-7706https://doaj.org/toc/1759-7714Abstract Background With the advent of high‐resolution chest imaging, the number of patients diagnosed with multiple primary lung cancers is increasing. For the treatment of multiple lung cancers, a surgical procedure that preserves pulmonary function while ensuring curability is required. Methods The study population included 85 patients with synchronous multiple primary lung cancer who received surgical resection between January 2010 and September 2020. Patients with synchronous lung cancer within the same lobe were excluded, and only patients with ≥2 involved lobes were included. The postoperative pulmonary function was examined at 3–6 months after the surgery. Results Sixty‐seven patients had cancers within the ipsilateral lobe, and 18 patients had cancers in bilateral lobes. Seventy‐six patients (89.4%) underwent combination surgery with limited resection (e.g., segmentectomy and wedge resection). The preoperative pulmonary functions (mean VC/%VC, mean FEV1/%FEV1, and mean %DLCO) were 3.06 L/100.2%, 2.23 L/96.1%, and 117.2%, respectively, and the postoperative pulmonary functions were 2.45 L/81.4%, 1.87 L/81.2%, and 102.6%. In each parameter, the predicted reductions of pulmonary function were almost the same as the predicted values. The 5‐year survival rate was 85.0%. The 5‐year survival rate according to the most advanced pathological stage was 94.9% for stage I disease, and 62.6% for stage ≥II, which was a significant difference (p < 0.001). Conclusions Surgical treatment including limited resection, especially segmentectomy and wedge resection, for synchronous multiple primary lung cancer can preserve pulmonary function while ensuring curability.Takuya WatanabeMasayuki TanahashiEriko SuzukiNaoko YoshiiHiroyuki TsuchidaShogo YobitaKensuke IguchiSuiha UchiyamaMinori NakamuraWileyarticlelimited resectionnon‐small cell lung cancerpulmonary functionsurgerysynchronous multiple lung cancerNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENThoracic Cancer, Vol 12, Iss 22, Pp 2996-3004 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	limited resection non‐small cell lung cancer pulmonary function surgery synchronous multiple lung cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	limited resection non‐small cell lung cancer pulmonary function surgery synchronous multiple lung cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Takuya Watanabe Masayuki Tanahashi Eriko Suzuki Naoko Yoshii Hiroyuki Tsuchida Shogo Yobita Kensuke Iguchi Suiha Uchiyama Minori Nakamura Surgical treatment for synchronous multiple primary lung cancer: Is it possible to achieve both curability and preservation of the pulmonary function?
description	Abstract Background With the advent of high‐resolution chest imaging, the number of patients diagnosed with multiple primary lung cancers is increasing. For the treatment of multiple lung cancers, a surgical procedure that preserves pulmonary function while ensuring curability is required. Methods The study population included 85 patients with synchronous multiple primary lung cancer who received surgical resection between January 2010 and September 2020. Patients with synchronous lung cancer within the same lobe were excluded, and only patients with ≥2 involved lobes were included. The postoperative pulmonary function was examined at 3–6 months after the surgery. Results Sixty‐seven patients had cancers within the ipsilateral lobe, and 18 patients had cancers in bilateral lobes. Seventy‐six patients (89.4%) underwent combination surgery with limited resection (e.g., segmentectomy and wedge resection). The preoperative pulmonary functions (mean VC/%VC, mean FEV1/%FEV1, and mean %DLCO) were 3.06 L/100.2%, 2.23 L/96.1%, and 117.2%, respectively, and the postoperative pulmonary functions were 2.45 L/81.4%, 1.87 L/81.2%, and 102.6%. In each parameter, the predicted reductions of pulmonary function were almost the same as the predicted values. The 5‐year survival rate was 85.0%. The 5‐year survival rate according to the most advanced pathological stage was 94.9% for stage I disease, and 62.6% for stage ≥II, which was a significant difference (p < 0.001). Conclusions Surgical treatment including limited resection, especially segmentectomy and wedge resection, for synchronous multiple primary lung cancer can preserve pulmonary function while ensuring curability.
format	article
author	Takuya Watanabe Masayuki Tanahashi Eriko Suzuki Naoko Yoshii Hiroyuki Tsuchida Shogo Yobita Kensuke Iguchi Suiha Uchiyama Minori Nakamura
author_facet	Takuya Watanabe Masayuki Tanahashi Eriko Suzuki Naoko Yoshii Hiroyuki Tsuchida Shogo Yobita Kensuke Iguchi Suiha Uchiyama Minori Nakamura
author_sort	Takuya Watanabe
title	Surgical treatment for synchronous multiple primary lung cancer: Is it possible to achieve both curability and preservation of the pulmonary function?
title_short	Surgical treatment for synchronous multiple primary lung cancer: Is it possible to achieve both curability and preservation of the pulmonary function?
title_full	Surgical treatment for synchronous multiple primary lung cancer: Is it possible to achieve both curability and preservation of the pulmonary function?
title_fullStr	Surgical treatment for synchronous multiple primary lung cancer: Is it possible to achieve both curability and preservation of the pulmonary function?
title_full_unstemmed	Surgical treatment for synchronous multiple primary lung cancer: Is it possible to achieve both curability and preservation of the pulmonary function?
title_sort	surgical treatment for synchronous multiple primary lung cancer: is it possible to achieve both curability and preservation of the pulmonary function?
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/d04224d8b9cf4f0383cdb3690f8687b0
work_keys_str_mv	AT takuyawatanabe surgicaltreatmentforsynchronousmultipleprimarylungcancerisitpossibletoachievebothcurabilityandpreservationofthepulmonaryfunction AT masayukitanahashi surgicaltreatmentforsynchronousmultipleprimarylungcancerisitpossibletoachievebothcurabilityandpreservationofthepulmonaryfunction AT erikosuzuki surgicaltreatmentforsynchronousmultipleprimarylungcancerisitpossibletoachievebothcurabilityandpreservationofthepulmonaryfunction AT naokoyoshii surgicaltreatmentforsynchronousmultipleprimarylungcancerisitpossibletoachievebothcurabilityandpreservationofthepulmonaryfunction AT hiroyukitsuchida surgicaltreatmentforsynchronousmultipleprimarylungcancerisitpossibletoachievebothcurabilityandpreservationofthepulmonaryfunction AT shogoyobita surgicaltreatmentforsynchronousmultipleprimarylungcancerisitpossibletoachievebothcurabilityandpreservationofthepulmonaryfunction AT kensukeiguchi surgicaltreatmentforsynchronousmultipleprimarylungcancerisitpossibletoachievebothcurabilityandpreservationofthepulmonaryfunction AT suihauchiyama surgicaltreatmentforsynchronousmultipleprimarylungcancerisitpossibletoachievebothcurabilityandpreservationofthepulmonaryfunction AT minorinakamura surgicaltreatmentforsynchronousmultipleprimarylungcancerisitpossibletoachievebothcurabilityandpreservationofthepulmonaryfunction
_version_	1718429011729711104

Surgical treatment for synchronous multiple primary lung cancer: Is it possible to achieve both curability and preservation of the pulmonary function?

Ejemplares similares