Clinical and biological correlates of morning serum cortisol in children and adolescents with overweight and obesity.

<h4>Background and aim</h4>A fraction of children with obesity have increased serum cortisol levels. In this study, we describe the clinical characteristics of obese children and adolescents with elevated morning serum cortisol levels and the relationship between the cortisol levels and...

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Autores principales:	Anton Martens, Bünyamin Duran, Jesse Vanbesien, Stephanie Verheyden, Bart Rutteman, Willem Staels, Ellen Anckaert, Inge Gies, Jean De Schepper
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d044f4e80d984647800effe08776f171
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spelling	oai:doaj.org-article:d044f4e80d984647800effe08776f1712021-12-02T20:16:43ZClinical and biological correlates of morning serum cortisol in children and adolescents with overweight and obesity.1932-620310.1371/journal.pone.0258653https://doaj.org/article/d044f4e80d984647800effe08776f1712021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0258653https://doaj.org/toc/1932-6203<h4>Background and aim</h4>A fraction of children with obesity have increased serum cortisol levels. In this study, we describe the clinical characteristics of obese children and adolescents with elevated morning serum cortisol levels and the relationship between the cortisol levels and components of the metabolic syndrome.<h4>Methods</h4>Retrospective medical record review study of children aged 4 to 18 years with overweight or obesity seen for obesity management in the Pediatric Obesity Clinic of the UZ Brussel between 2013 and 2015.<h4>Results</h4>A total of 234 children (99 boys and 135 girls) with overweight (BMI z-score > 1.3) without underlying endocrine or genetic conditions were included. Mean (SD) age was 10.1 (2.8) years, BMI SD-score 2.5 (0.6), and body fat percentage 37% (7.9). Serum fasting cortisol levels were elevated (>180 μg/L) in 49 children, normal (62-180 μg/L) in 168, and decreased (<62 μg/L) in 12. Serum fasting cortisol was not significantly correlated with gender, age, or degree of adiposity. But correlated significantly with fasting glucose (Rs = 0.193; p < 0.005), triglycerides (Rs = 0. 143; p < 0.05), fibrinogen (Rs = 0.144; p < 0.05) and leptin levels (Rs = 0.145; p < 0.05). After adjustment for serum insulin and leptin, the correlation between serum cortisol and fasting glucose remained significant.<h4>Conclusion</h4>Elevated morning serum cortisol levels were found in 20% of overweight or obese children and adolescents, irrespective of the degree of adiposity, and were associated with higher fasting glucose, irrespective of underlying insulin resistance. The long-term cardiometabolic consequences of hypercortisolemia in childhood obesity needs further study.Anton MartensBünyamin DuranJesse VanbesienStephanie VerheydenBart RuttemanWillem StaelsEllen AnckaertInge GiesJean De SchepperPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 10, p e0258653 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Anton Martens Bünyamin Duran Jesse Vanbesien Stephanie Verheyden Bart Rutteman Willem Staels Ellen Anckaert Inge Gies Jean De Schepper Clinical and biological correlates of morning serum cortisol in children and adolescents with overweight and obesity.
description	<h4>Background and aim</h4>A fraction of children with obesity have increased serum cortisol levels. In this study, we describe the clinical characteristics of obese children and adolescents with elevated morning serum cortisol levels and the relationship between the cortisol levels and components of the metabolic syndrome.<h4>Methods</h4>Retrospective medical record review study of children aged 4 to 18 years with overweight or obesity seen for obesity management in the Pediatric Obesity Clinic of the UZ Brussel between 2013 and 2015.<h4>Results</h4>A total of 234 children (99 boys and 135 girls) with overweight (BMI z-score > 1.3) without underlying endocrine or genetic conditions were included. Mean (SD) age was 10.1 (2.8) years, BMI SD-score 2.5 (0.6), and body fat percentage 37% (7.9). Serum fasting cortisol levels were elevated (>180 μg/L) in 49 children, normal (62-180 μg/L) in 168, and decreased (<62 μg/L) in 12. Serum fasting cortisol was not significantly correlated with gender, age, or degree of adiposity. But correlated significantly with fasting glucose (Rs = 0.193; p < 0.005), triglycerides (Rs = 0. 143; p < 0.05), fibrinogen (Rs = 0.144; p < 0.05) and leptin levels (Rs = 0.145; p < 0.05). After adjustment for serum insulin and leptin, the correlation between serum cortisol and fasting glucose remained significant.<h4>Conclusion</h4>Elevated morning serum cortisol levels were found in 20% of overweight or obese children and adolescents, irrespective of the degree of adiposity, and were associated with higher fasting glucose, irrespective of underlying insulin resistance. The long-term cardiometabolic consequences of hypercortisolemia in childhood obesity needs further study.
format	article
author	Anton Martens Bünyamin Duran Jesse Vanbesien Stephanie Verheyden Bart Rutteman Willem Staels Ellen Anckaert Inge Gies Jean De Schepper
author_facet	Anton Martens Bünyamin Duran Jesse Vanbesien Stephanie Verheyden Bart Rutteman Willem Staels Ellen Anckaert Inge Gies Jean De Schepper
author_sort	Anton Martens
title	Clinical and biological correlates of morning serum cortisol in children and adolescents with overweight and obesity.
title_short	Clinical and biological correlates of morning serum cortisol in children and adolescents with overweight and obesity.
title_full	Clinical and biological correlates of morning serum cortisol in children and adolescents with overweight and obesity.
title_fullStr	Clinical and biological correlates of morning serum cortisol in children and adolescents with overweight and obesity.
title_full_unstemmed	Clinical and biological correlates of morning serum cortisol in children and adolescents with overweight and obesity.
title_sort	clinical and biological correlates of morning serum cortisol in children and adolescents with overweight and obesity.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/d044f4e80d984647800effe08776f171
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Clinical and biological correlates of morning serum cortisol in children and adolescents with overweight and obesity.

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