Cognitive frailty among Malaysian older adults: baseline findings from the LRGS TUA cohort study

Nurul Fatin Malek Rivan,1 Suzana Shahar,2 Nor Fadilah Rajab,3 Devinder Kaur Ajit Singh,4 Normah Che Din,5 Mahadzir Hazlina,6 Tengku Aizan Tengku Abdul Hamid71Nutritional Sciences Programme and Centre for Healthy Ageing and Wellness (H-CARE), Faculty of Health Sciences, Universiti Kebangsaan Malaysia...

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Autores principales:	Malek Rivan NF, Shahar S, Rajab NF, Singh DKA, Din NC, Hazlina M, Hamid TATA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	frailty mild cognitive impairment cognitive frailty older adults Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/d045a3683bd740a7a8eb85fd20ed7a13
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spelling	oai:doaj.org-article:d045a3683bd740a7a8eb85fd20ed7a132021-12-02T07:58:07ZCognitive frailty among Malaysian older adults: baseline findings from the LRGS TUA cohort study1178-1998https://doaj.org/article/d045a3683bd740a7a8eb85fd20ed7a132019-07-01T00:00:00Zhttps://www.dovepress.com/cognitive-frailty-among-malaysian-older-adults-baseline-findings-from--peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Nurul Fatin Malek Rivan,1 Suzana Shahar,2 Nor Fadilah Rajab,3 Devinder Kaur Ajit Singh,4 Normah Che Din,5 Mahadzir Hazlina,6 Tengku Aizan Tengku Abdul Hamid71Nutritional Sciences Programme and Centre for Healthy Ageing and Wellness (H-CARE), Faculty of Health Sciences, Universiti Kebangsaan Malaysia, 50300 Kuala Lumpur, Malaysia; 2Dietetics Programme and Centre for Healthy Ageing and Wellness (H-CARE), Faculty of Health Sciences, Universiti Kebangsaan Malaysia, 50300 Kuala Lumpur, Malaysia; 3Biomedical Science Programme, School of Diagnostic and Applied Health Sciences, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, 50300 Kuala Lumpur, Malaysia; 4Physiotherapy Programme, School of Rehabilitation Sciences, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia; 5Health Psychology Programme and Centre for Healthy Ageing and Wellness (H-CARE), Faculty of Health Sciences, Universiti Kebangsaan Malaysia, 50300 Kuala Lumpur, Malaysia; 6Internal Medicine & Geriatric Department, Pusat Perubatan Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia; 7Malaysian Research Institute on Ageing, Universiti Putra Malaysia, 43400 Serdang, Selangor, MalaysiaPurpose: This study was aimed at determining the presence of cognitive frailty and its associated factors among community-dwelling older adults from the “LRGS-Towards Useful Aging (TUA)” longitudinal study.Patients and methods: The available data related to cognitive frailty among a sub-sample of older adults aged 60 years and above (n=815) from two states in Malaysia were analysed. In the LRGS-TUA study, a comprehensive interview-based questionnaire was administered to obtain the socio-demographic information of the participants, followed by assessments to examine the cognitive function, functional status, dietary intake, lifestyle, psychosocial status and biomarkers associated with cognitive frailty. The factors associated with cognitive frailty were assessed using a bivariate logistic regression (BLR).Results: The majority of the older adults were categorized as robust (68.4%), followed by cognitively pre-frail (37.4%) and cognitively frail (2.2%). The data on the cognitively frail and pre-frail groups were combined for comparison with the robust group. A hierarchical BLR indicated that advancing age (OR=1.04, 95% CI:1.01–1.08, p<0.05) and depression (OR=1.49, 95% CI:1.34–1.65, p<0.001) scored lower on the Activity of Daily Living (ADL) scale (OR=0.98, 95% CI:0.96–0.99, p<0.05), while low social support (OR=0.98, 95% CI:0.97–0.99, p<0.05) and low niacin intake (OR=0.94, 95% CI:0.89–0.99, p<0.05) were found to be significant factors for cognitive frailty. Higher oxidative stress (MDA) and lower telomerase activity were also associated with cognitive frailty (p<0.05).Conclusion: Older age, a lower niacin intake, lack of social support, depression and lower functional status were identified as significant factors associated with cognitive frailty among older Malaysian adults. MDA and telomerase activity can be used as potential biomarkers for the identification of cognitive frailty.Keywords: frailty, mild cognitive impairment, cognitive frailty, older adultsMalek Rivan NFShahar SRajab NFSingh DKADin NCHazlina MHamid TATADove Medical Pressarticlefrailtymild cognitive impairmentcognitive frailtyolder adultsGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 14, Pp 1343-1352 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	frailty mild cognitive impairment cognitive frailty older adults Geriatrics RC952-954.6
spellingShingle	frailty mild cognitive impairment cognitive frailty older adults Geriatrics RC952-954.6 Malek Rivan NF Shahar S Rajab NF Singh DKA Din NC Hazlina M Hamid TATA Cognitive frailty among Malaysian older adults: baseline findings from the LRGS TUA cohort study
description	Nurul Fatin Malek Rivan,1 Suzana Shahar,2 Nor Fadilah Rajab,3 Devinder Kaur Ajit Singh,4 Normah Che Din,5 Mahadzir Hazlina,6 Tengku Aizan Tengku Abdul Hamid71Nutritional Sciences Programme and Centre for Healthy Ageing and Wellness (H-CARE), Faculty of Health Sciences, Universiti Kebangsaan Malaysia, 50300 Kuala Lumpur, Malaysia; 2Dietetics Programme and Centre for Healthy Ageing and Wellness (H-CARE), Faculty of Health Sciences, Universiti Kebangsaan Malaysia, 50300 Kuala Lumpur, Malaysia; 3Biomedical Science Programme, School of Diagnostic and Applied Health Sciences, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, 50300 Kuala Lumpur, Malaysia; 4Physiotherapy Programme, School of Rehabilitation Sciences, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia; 5Health Psychology Programme and Centre for Healthy Ageing and Wellness (H-CARE), Faculty of Health Sciences, Universiti Kebangsaan Malaysia, 50300 Kuala Lumpur, Malaysia; 6Internal Medicine & Geriatric Department, Pusat Perubatan Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia; 7Malaysian Research Institute on Ageing, Universiti Putra Malaysia, 43400 Serdang, Selangor, MalaysiaPurpose: This study was aimed at determining the presence of cognitive frailty and its associated factors among community-dwelling older adults from the “LRGS-Towards Useful Aging (TUA)” longitudinal study.Patients and methods: The available data related to cognitive frailty among a sub-sample of older adults aged 60 years and above (n=815) from two states in Malaysia were analysed. In the LRGS-TUA study, a comprehensive interview-based questionnaire was administered to obtain the socio-demographic information of the participants, followed by assessments to examine the cognitive function, functional status, dietary intake, lifestyle, psychosocial status and biomarkers associated with cognitive frailty. The factors associated with cognitive frailty were assessed using a bivariate logistic regression (BLR).Results: The majority of the older adults were categorized as robust (68.4%), followed by cognitively pre-frail (37.4%) and cognitively frail (2.2%). The data on the cognitively frail and pre-frail groups were combined for comparison with the robust group. A hierarchical BLR indicated that advancing age (OR=1.04, 95% CI:1.01–1.08, p<0.05) and depression (OR=1.49, 95% CI:1.34–1.65, p<0.001) scored lower on the Activity of Daily Living (ADL) scale (OR=0.98, 95% CI:0.96–0.99, p<0.05), while low social support (OR=0.98, 95% CI:0.97–0.99, p<0.05) and low niacin intake (OR=0.94, 95% CI:0.89–0.99, p<0.05) were found to be significant factors for cognitive frailty. Higher oxidative stress (MDA) and lower telomerase activity were also associated with cognitive frailty (p<0.05).Conclusion: Older age, a lower niacin intake, lack of social support, depression and lower functional status were identified as significant factors associated with cognitive frailty among older Malaysian adults. MDA and telomerase activity can be used as potential biomarkers for the identification of cognitive frailty.Keywords: frailty, mild cognitive impairment, cognitive frailty, older adults
format	article
author	Malek Rivan NF Shahar S Rajab NF Singh DKA Din NC Hazlina M Hamid TATA
author_facet	Malek Rivan NF Shahar S Rajab NF Singh DKA Din NC Hazlina M Hamid TATA
author_sort	Malek Rivan NF
title	Cognitive frailty among Malaysian older adults: baseline findings from the LRGS TUA cohort study
title_short	Cognitive frailty among Malaysian older adults: baseline findings from the LRGS TUA cohort study
title_full	Cognitive frailty among Malaysian older adults: baseline findings from the LRGS TUA cohort study
title_fullStr	Cognitive frailty among Malaysian older adults: baseline findings from the LRGS TUA cohort study
title_full_unstemmed	Cognitive frailty among Malaysian older adults: baseline findings from the LRGS TUA cohort study
title_sort	cognitive frailty among malaysian older adults: baseline findings from the lrgs tua cohort study
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/d045a3683bd740a7a8eb85fd20ed7a13
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Cognitive frailty among Malaysian older adults: baseline findings from the LRGS TUA cohort study

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