Heterologous prime-boost vaccination with H3N2 influenza viruses of swine favors cross-clade antibody responses and protection

Influenza: More efficient, more protective vaccinations Boosting an influenza vaccine with a different strain offers twice the protection for half the volume of vaccine. Pigs and humans need two doses of killed influenza vaccine—a “priming” dose, with a “booster” given approximately 4 weeks after—in...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Kristien Van Reeth, José Carlos Mancera Gracia, Ivan Trus, Lieve Sys, Gerwin Claes, Han Versnaeyen, Eric Cox, Florian Krammer, Yu Qiu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/d047b67c05bd434cbd6e74179417e3fd
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d047b67c05bd434cbd6e74179417e3fd
record_format	dspace
spelling	oai:doaj.org-article:d047b67c05bd434cbd6e74179417e3fd2021-12-02T11:50:55ZHeterologous prime-boost vaccination with H3N2 influenza viruses of swine favors cross-clade antibody responses and protection10.1038/s41541-017-0012-x2059-0105https://doaj.org/article/d047b67c05bd434cbd6e74179417e3fd2017-04-01T00:00:00Zhttps://doi.org/10.1038/s41541-017-0012-xhttps://doaj.org/toc/2059-0105Influenza: More efficient, more protective vaccinations Boosting an influenza vaccine with a different strain offers twice the protection for half the volume of vaccine. Pigs and humans need two doses of killed influenza vaccine—a “priming” dose, with a “booster” given approximately 4 weeks after—in order to provide immunity. Kristien Van Reeth, of Belgium’s Ghent University, and collaborators demonstrated that differing the strain of the primer and booster elicits antibodies that protect against both strains, negating the need for two doses of both strains. The swine vaccinated in Van Reeth’s study also had increased immunity against strains that the animals were not vaccinated against but bore similarities to the viruses used. This cross-protection corresponds with conclusions from similar research into other animals and could eliminate the need for unnecessary vaccinations whilst increasing vaccine efficacy in swine and presumably in humans.Kristien Van ReethJosé Carlos Mancera GraciaIvan TrusLieve SysGerwin ClaesHan VersnaeyenEric CoxFlorian KrammerYu QiuNature PortfolioarticleImmunologic diseases. AllergyRC581-607Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Vaccines, Vol 2, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Kristien Van Reeth José Carlos Mancera Gracia Ivan Trus Lieve Sys Gerwin Claes Han Versnaeyen Eric Cox Florian Krammer Yu Qiu Heterologous prime-boost vaccination with H3N2 influenza viruses of swine favors cross-clade antibody responses and protection
description	Influenza: More efficient, more protective vaccinations Boosting an influenza vaccine with a different strain offers twice the protection for half the volume of vaccine. Pigs and humans need two doses of killed influenza vaccine—a “priming” dose, with a “booster” given approximately 4 weeks after—in order to provide immunity. Kristien Van Reeth, of Belgium’s Ghent University, and collaborators demonstrated that differing the strain of the primer and booster elicits antibodies that protect against both strains, negating the need for two doses of both strains. The swine vaccinated in Van Reeth’s study also had increased immunity against strains that the animals were not vaccinated against but bore similarities to the viruses used. This cross-protection corresponds with conclusions from similar research into other animals and could eliminate the need for unnecessary vaccinations whilst increasing vaccine efficacy in swine and presumably in humans.
format	article
author	Kristien Van Reeth José Carlos Mancera Gracia Ivan Trus Lieve Sys Gerwin Claes Han Versnaeyen Eric Cox Florian Krammer Yu Qiu
author_facet	Kristien Van Reeth José Carlos Mancera Gracia Ivan Trus Lieve Sys Gerwin Claes Han Versnaeyen Eric Cox Florian Krammer Yu Qiu
author_sort	Kristien Van Reeth
title	Heterologous prime-boost vaccination with H3N2 influenza viruses of swine favors cross-clade antibody responses and protection
title_short	Heterologous prime-boost vaccination with H3N2 influenza viruses of swine favors cross-clade antibody responses and protection
title_full	Heterologous prime-boost vaccination with H3N2 influenza viruses of swine favors cross-clade antibody responses and protection
title_fullStr	Heterologous prime-boost vaccination with H3N2 influenza viruses of swine favors cross-clade antibody responses and protection
title_full_unstemmed	Heterologous prime-boost vaccination with H3N2 influenza viruses of swine favors cross-clade antibody responses and protection
title_sort	heterologous prime-boost vaccination with h3n2 influenza viruses of swine favors cross-clade antibody responses and protection
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/d047b67c05bd434cbd6e74179417e3fd
work_keys_str_mv	AT kristienvanreeth heterologousprimeboostvaccinationwithh3n2influenzavirusesofswinefavorscrosscladeantibodyresponsesandprotection AT josecarlosmanceragracia heterologousprimeboostvaccinationwithh3n2influenzavirusesofswinefavorscrosscladeantibodyresponsesandprotection AT ivantrus heterologousprimeboostvaccinationwithh3n2influenzavirusesofswinefavorscrosscladeantibodyresponsesandprotection AT lievesys heterologousprimeboostvaccinationwithh3n2influenzavirusesofswinefavorscrosscladeantibodyresponsesandprotection AT gerwinclaes heterologousprimeboostvaccinationwithh3n2influenzavirusesofswinefavorscrosscladeantibodyresponsesandprotection AT hanversnaeyen heterologousprimeboostvaccinationwithh3n2influenzavirusesofswinefavorscrosscladeantibodyresponsesandprotection AT ericcox heterologousprimeboostvaccinationwithh3n2influenzavirusesofswinefavorscrosscladeantibodyresponsesandprotection AT floriankrammer heterologousprimeboostvaccinationwithh3n2influenzavirusesofswinefavorscrosscladeantibodyresponsesandprotection AT yuqiu heterologousprimeboostvaccinationwithh3n2influenzavirusesofswinefavorscrosscladeantibodyresponsesandprotection
_version_	1718395191865376768

Heterologous prime-boost vaccination with H3N2 influenza viruses of swine favors cross-clade antibody responses and protection

Ejemplares similares