Identification of juvenility-associated genes in the mouse hepatocytes and cardiomyocytes

Abstract Young individuals possess distinct properties that adults do not. The juvenile animals show higher activities for growth, healing, learning and plasticity than adults. The machinery for establishing these juvenile properties is not fully understood. To better understand the molecular consti...

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Autores principales:	Faidruz Azura Jam, Yosuke Kadota, Anarmaa Mendsaikhan, Ikuo Tooyama, Masaki Mori
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d047ec3d707d4ec6a497165c3e81efe8
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spelling	oai:doaj.org-article:d047ec3d707d4ec6a497165c3e81efe82021-12-02T15:08:55ZIdentification of juvenility-associated genes in the mouse hepatocytes and cardiomyocytes10.1038/s41598-018-21445-32045-2322https://doaj.org/article/d047ec3d707d4ec6a497165c3e81efe82018-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-21445-3https://doaj.org/toc/2045-2322Abstract Young individuals possess distinct properties that adults do not. The juvenile animals show higher activities for growth, healing, learning and plasticity than adults. The machinery for establishing these juvenile properties is not fully understood. To better understand the molecular constituents for the above properties, we performed a comprehensive transcriptome analysis of differently aged cells of mice by high-throughput sequencing and identified the genes selectively highly expressed in the young cells. These genes, collectively called as juvenility-associated genes (JAGs), show significant enrichments in the functions such as alternative splicing, phosphorylation and extracellular matrix (ECM). This implies the juvenescence might be achieved by these functions at the cell level. The JAG mutations are associated with progeria syndromes and growth disorders. Thus, the JAGs might organize the juvenile property of young animals and analysis of JAGs may provide scientific and therapeutic approaches toward treating the genetic diseases.Faidruz Azura JamYosuke KadotaAnarmaa MendsaikhanIkuo TooyamaMasaki MoriNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Faidruz Azura Jam Yosuke Kadota Anarmaa Mendsaikhan Ikuo Tooyama Masaki Mori Identification of juvenility-associated genes in the mouse hepatocytes and cardiomyocytes
description	Abstract Young individuals possess distinct properties that adults do not. The juvenile animals show higher activities for growth, healing, learning and plasticity than adults. The machinery for establishing these juvenile properties is not fully understood. To better understand the molecular constituents for the above properties, we performed a comprehensive transcriptome analysis of differently aged cells of mice by high-throughput sequencing and identified the genes selectively highly expressed in the young cells. These genes, collectively called as juvenility-associated genes (JAGs), show significant enrichments in the functions such as alternative splicing, phosphorylation and extracellular matrix (ECM). This implies the juvenescence might be achieved by these functions at the cell level. The JAG mutations are associated with progeria syndromes and growth disorders. Thus, the JAGs might organize the juvenile property of young animals and analysis of JAGs may provide scientific and therapeutic approaches toward treating the genetic diseases.
format	article
author	Faidruz Azura Jam Yosuke Kadota Anarmaa Mendsaikhan Ikuo Tooyama Masaki Mori
author_facet	Faidruz Azura Jam Yosuke Kadota Anarmaa Mendsaikhan Ikuo Tooyama Masaki Mori
author_sort	Faidruz Azura Jam
title	Identification of juvenility-associated genes in the mouse hepatocytes and cardiomyocytes
title_short	Identification of juvenility-associated genes in the mouse hepatocytes and cardiomyocytes
title_full	Identification of juvenility-associated genes in the mouse hepatocytes and cardiomyocytes
title_fullStr	Identification of juvenility-associated genes in the mouse hepatocytes and cardiomyocytes
title_full_unstemmed	Identification of juvenility-associated genes in the mouse hepatocytes and cardiomyocytes
title_sort	identification of juvenility-associated genes in the mouse hepatocytes and cardiomyocytes
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/d047ec3d707d4ec6a497165c3e81efe8
work_keys_str_mv	AT faidruzazurajam identificationofjuvenilityassociatedgenesinthemousehepatocytesandcardiomyocytes AT yosukekadota identificationofjuvenilityassociatedgenesinthemousehepatocytesandcardiomyocytes AT anarmaamendsaikhan identificationofjuvenilityassociatedgenesinthemousehepatocytesandcardiomyocytes AT ikuotooyama identificationofjuvenilityassociatedgenesinthemousehepatocytesandcardiomyocytes AT masakimori identificationofjuvenilityassociatedgenesinthemousehepatocytesandcardiomyocytes
_version_	1718387967841533952

Identification of juvenility-associated genes in the mouse hepatocytes and cardiomyocytes

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