Serum Uric Acid Levels and Metabolic Indices in an Obese Population: A Cross-Sectional Study

Fen Li,1,2 Sheng Chen,2 Xinwen Qiu,2 Jing Wu,1 Min Tan,1 Min Wang1 1Department of Endocrinology, Xiangya Hospital, Central South University, Changsha, People’s Republic of China; 2Department of Endocrinology and Metabolism, Liuyang People’s Hospital, Changsha, People’s...

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Autores principales:	Li F, Chen S, Qiu X, Wu J, Tan M, Wang M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	obesity hyperuricemia insulin resistance Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/d049561a84cb4b52bcb76e293160829b
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spelling	oai:doaj.org-article:d049561a84cb4b52bcb76e293160829b2021-12-02T14:24:11ZSerum Uric Acid Levels and Metabolic Indices in an Obese Population: A Cross-Sectional Study1178-7007https://doaj.org/article/d049561a84cb4b52bcb76e293160829b2021-02-01T00:00:00Zhttps://www.dovepress.com/serum-uric-acid-levels-and-metabolic-indices-in-an-obese-population-a--peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Fen Li,1,2 Sheng Chen,2 Xinwen Qiu,2 Jing Wu,1 Min Tan,1 Min Wang1 1Department of Endocrinology, Xiangya Hospital, Central South University, Changsha, People’s Republic of China; 2Department of Endocrinology and Metabolism, Liuyang People’s Hospital, Changsha, People’s Republic of ChinaCorrespondence: Min WangDepartment of Endocrinology, Xiangya Hospital, Central South University, Changsha, People’s Republic of ChinaTel +86-135-0731-5620Email 19650877@qq.comObjective: To analyze the association between serum uric acid (SUA) and metabolic state in obese inpatients and preliminarily explore potential mechanisms of hyperuricemia in obesity.Methods: A total of 153 obese inpatients were selected and assigned based on SUA level to the normal uric acid (NC group) or high uric acid (HUA) group. Patients’ sex, age, height, weight, blood pressure, BMI, and prevalence of metabolic syndrome were collected and recorded. SUA, FPG, FIns, HOMA-IR, HOMA-IS, HbA1c, TGs, TC, LDL-C, and HDL-C levels were tested. Pearson correlation analysis was performed to analyze the correlation between SUA and related metabolic indicators. Logistic regression was performed to analyze independent risk factors of hyperuricemia in obesity.Results: In the HUA group, the patients were predominantly males, and BMI, DBP, TGs, FPG, FIns, HOMA-IR, HOMA-IS, and metabolic syndrome were higher than those in the NC group (P< 0.05), while HDL-C was lower than that in the NC group (P< 0.05). There were no significant differences between the groups in TC or LDL-C. Pearson correlation analysis showed that in obese patients, SUA was positively correlated with BMI, FIns, HOMA-IR, HOMA-IS, TGs, andmetabolic syndrome and negatively correlated with age and HDL-C. Logistic regression showed that BMI, hyperinsulinemia, and insulin resistance were independent risk factors of hyperuricemia.Conclusion: Development of hyperuricemia in obese populations might be correlated with hyperinsulinemia or insulin resistance.Keywords: obesity, hyperuricemia, insulin resistanceLi FChen SQiu XWu JTan MWang MDove Medical Pressarticleobesityhyperuricemiainsulin resistanceSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 14, Pp 627-635 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	obesity hyperuricemia insulin resistance Specialties of internal medicine RC581-951
spellingShingle	obesity hyperuricemia insulin resistance Specialties of internal medicine RC581-951 Li F Chen S Qiu X Wu J Tan M Wang M Serum Uric Acid Levels and Metabolic Indices in an Obese Population: A Cross-Sectional Study
description	Fen Li,1,2 Sheng Chen,2 Xinwen Qiu,2 Jing Wu,1 Min Tan,1 Min Wang1 1Department of Endocrinology, Xiangya Hospital, Central South University, Changsha, People’s Republic of China; 2Department of Endocrinology and Metabolism, Liuyang People’s Hospital, Changsha, People’s Republic of ChinaCorrespondence: Min WangDepartment of Endocrinology, Xiangya Hospital, Central South University, Changsha, People’s Republic of ChinaTel +86-135-0731-5620Email 19650877@qq.comObjective: To analyze the association between serum uric acid (SUA) and metabolic state in obese inpatients and preliminarily explore potential mechanisms of hyperuricemia in obesity.Methods: A total of 153 obese inpatients were selected and assigned based on SUA level to the normal uric acid (NC group) or high uric acid (HUA) group. Patients’ sex, age, height, weight, blood pressure, BMI, and prevalence of metabolic syndrome were collected and recorded. SUA, FPG, FIns, HOMA-IR, HOMA-IS, HbA1c, TGs, TC, LDL-C, and HDL-C levels were tested. Pearson correlation analysis was performed to analyze the correlation between SUA and related metabolic indicators. Logistic regression was performed to analyze independent risk factors of hyperuricemia in obesity.Results: In the HUA group, the patients were predominantly males, and BMI, DBP, TGs, FPG, FIns, HOMA-IR, HOMA-IS, and metabolic syndrome were higher than those in the NC group (P< 0.05), while HDL-C was lower than that in the NC group (P< 0.05). There were no significant differences between the groups in TC or LDL-C. Pearson correlation analysis showed that in obese patients, SUA was positively correlated with BMI, FIns, HOMA-IR, HOMA-IS, TGs, andmetabolic syndrome and negatively correlated with age and HDL-C. Logistic regression showed that BMI, hyperinsulinemia, and insulin resistance were independent risk factors of hyperuricemia.Conclusion: Development of hyperuricemia in obese populations might be correlated with hyperinsulinemia or insulin resistance.Keywords: obesity, hyperuricemia, insulin resistance
format	article
author	Li F Chen S Qiu X Wu J Tan M Wang M
author_facet	Li F Chen S Qiu X Wu J Tan M Wang M
author_sort	Li F
title	Serum Uric Acid Levels and Metabolic Indices in an Obese Population: A Cross-Sectional Study
title_short	Serum Uric Acid Levels and Metabolic Indices in an Obese Population: A Cross-Sectional Study
title_full	Serum Uric Acid Levels and Metabolic Indices in an Obese Population: A Cross-Sectional Study
title_fullStr	Serum Uric Acid Levels and Metabolic Indices in an Obese Population: A Cross-Sectional Study
title_full_unstemmed	Serum Uric Acid Levels and Metabolic Indices in an Obese Population: A Cross-Sectional Study
title_sort	serum uric acid levels and metabolic indices in an obese population: a cross-sectional study
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/d049561a84cb4b52bcb76e293160829b
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Serum Uric Acid Levels and Metabolic Indices in an Obese Population: A Cross-Sectional Study

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