The Immediate Effects of Intermittent Theta Burst Stimulation of the Cerebellar Vermis on Cerebral Cortical Excitability During a Balance Task in Healthy Individuals: A Pilot Study
Objective: This pilot study aimed to investigate the immediate effects of single-session intermittent theta-burst stimulation (iTBS) on the cerebellar vermis during a balance task, which could unveil the changes of cerebral cortical excitability in healthy individuals.Subjects: A total of seven righ...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:d04e99ac09f74474897275c6be4c013c2021-11-12T05:10:47ZThe Immediate Effects of Intermittent Theta Burst Stimulation of the Cerebellar Vermis on Cerebral Cortical Excitability During a Balance Task in Healthy Individuals: A Pilot Study1662-516110.3389/fnhum.2021.748241https://doaj.org/article/d04e99ac09f74474897275c6be4c013c2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnhum.2021.748241/fullhttps://doaj.org/toc/1662-5161Objective: This pilot study aimed to investigate the immediate effects of single-session intermittent theta-burst stimulation (iTBS) on the cerebellar vermis during a balance task, which could unveil the changes of cerebral cortical excitability in healthy individuals.Subjects: A total of seven right-handed healthy subjects (26.86 ± 5.30 years) were included in this study.Interventions: Each subject received single-session iTBS on cerebellar vermis in a sitting position.Main Measures: Before and after the intervention, all subjects were asked to repeat the balance task of standing on the left leg three times. Each task consisted of 15 s of standing and 20 s of resting. Real-time changes in cerebral cortex oxygen concentrations were monitored with functional near-infrared spectroscopy (fNIRS). During the task, changes in blood oxygen concentration were recorded and converted into the mean HbO2 for statistical analysis.Results: After stimulation, the mean HbO2 in the left SMA (P = 0.029) and right SMA (P = 0.043) significantly increased compared with baseline. However, no significant changes of mean HbO2 were found in the bilateral dorsolateral prefrontal lobe (P > 0.05).Conclusion: Single-session iTBS on the cerebellar vermis in healthy adults can increase the excitability of the cerebral cortex in the bilateral supplementary motor areas during balance tasks.Clinical Trial Registration: [www.ClinicalTrials.gov], identifier [ChiCTR2100048915].Hui-Xin TanHui-Xin TanQing-Chuan WeiQing-Chuan WeiYi ChenYi ChenYun-Juan XieYun-Juan XieQi-Fan GuoQi-Fan GuoLin HeLin HeQiang GaoQiang GaoFrontiers Media S.A.articleintermittent theta-burst stimulationcerebellar vermisbalancefunctional near-infrared spectroscopytranscrancial magnetic stimulation (TMS)Neurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Human Neuroscience, Vol 15 (2021) |
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intermittent theta-burst stimulation cerebellar vermis balance functional near-infrared spectroscopy transcrancial magnetic stimulation (TMS) Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 |
| spellingShingle |
intermittent theta-burst stimulation cerebellar vermis balance functional near-infrared spectroscopy transcrancial magnetic stimulation (TMS) Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Hui-Xin Tan Hui-Xin Tan Qing-Chuan Wei Qing-Chuan Wei Yi Chen Yi Chen Yun-Juan Xie Yun-Juan Xie Qi-Fan Guo Qi-Fan Guo Lin He Lin He Qiang Gao Qiang Gao The Immediate Effects of Intermittent Theta Burst Stimulation of the Cerebellar Vermis on Cerebral Cortical Excitability During a Balance Task in Healthy Individuals: A Pilot Study |
| description |
Objective: This pilot study aimed to investigate the immediate effects of single-session intermittent theta-burst stimulation (iTBS) on the cerebellar vermis during a balance task, which could unveil the changes of cerebral cortical excitability in healthy individuals.Subjects: A total of seven right-handed healthy subjects (26.86 ± 5.30 years) were included in this study.Interventions: Each subject received single-session iTBS on cerebellar vermis in a sitting position.Main Measures: Before and after the intervention, all subjects were asked to repeat the balance task of standing on the left leg three times. Each task consisted of 15 s of standing and 20 s of resting. Real-time changes in cerebral cortex oxygen concentrations were monitored with functional near-infrared spectroscopy (fNIRS). During the task, changes in blood oxygen concentration were recorded and converted into the mean HbO2 for statistical analysis.Results: After stimulation, the mean HbO2 in the left SMA (P = 0.029) and right SMA (P = 0.043) significantly increased compared with baseline. However, no significant changes of mean HbO2 were found in the bilateral dorsolateral prefrontal lobe (P > 0.05).Conclusion: Single-session iTBS on the cerebellar vermis in healthy adults can increase the excitability of the cerebral cortex in the bilateral supplementary motor areas during balance tasks.Clinical Trial Registration: [www.ClinicalTrials.gov], identifier [ChiCTR2100048915]. |
| format |
article |
| author |
Hui-Xin Tan Hui-Xin Tan Qing-Chuan Wei Qing-Chuan Wei Yi Chen Yi Chen Yun-Juan Xie Yun-Juan Xie Qi-Fan Guo Qi-Fan Guo Lin He Lin He Qiang Gao Qiang Gao |
| author_facet |
Hui-Xin Tan Hui-Xin Tan Qing-Chuan Wei Qing-Chuan Wei Yi Chen Yi Chen Yun-Juan Xie Yun-Juan Xie Qi-Fan Guo Qi-Fan Guo Lin He Lin He Qiang Gao Qiang Gao |
| author_sort |
Hui-Xin Tan |
| title |
The Immediate Effects of Intermittent Theta Burst Stimulation of the Cerebellar Vermis on Cerebral Cortical Excitability During a Balance Task in Healthy Individuals: A Pilot Study |
| title_short |
The Immediate Effects of Intermittent Theta Burst Stimulation of the Cerebellar Vermis on Cerebral Cortical Excitability During a Balance Task in Healthy Individuals: A Pilot Study |
| title_full |
The Immediate Effects of Intermittent Theta Burst Stimulation of the Cerebellar Vermis on Cerebral Cortical Excitability During a Balance Task in Healthy Individuals: A Pilot Study |
| title_fullStr |
The Immediate Effects of Intermittent Theta Burst Stimulation of the Cerebellar Vermis on Cerebral Cortical Excitability During a Balance Task in Healthy Individuals: A Pilot Study |
| title_full_unstemmed |
The Immediate Effects of Intermittent Theta Burst Stimulation of the Cerebellar Vermis on Cerebral Cortical Excitability During a Balance Task in Healthy Individuals: A Pilot Study |
| title_sort |
immediate effects of intermittent theta burst stimulation of the cerebellar vermis on cerebral cortical excitability during a balance task in healthy individuals: a pilot study |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/d04e99ac09f74474897275c6be4c013c |
| work_keys_str_mv |
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