Cortical Up states induce the selective weakening of subthreshold synaptic inputs

Slow oscillations between cortical Up and Down states are a defining feature of deep sleep, but their function is not well understood. Here the authors study Up/Down states in acute slices of entorhinal cortex, and find that Up states promote the weakening of subthreshold synaptic inputs, while supr...

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Autores principales:	Julian Bartram, Martin C. Kahn, Simon Tuohy, Ole Paulsen, Tony Wilson, Edward O. Mann
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d050c69f21184ee49fef200abbf869b2
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spelling	oai:doaj.org-article:d050c69f21184ee49fef200abbf869b22021-12-02T14:40:58ZCortical Up states induce the selective weakening of subthreshold synaptic inputs10.1038/s41467-017-00748-52041-1723https://doaj.org/article/d050c69f21184ee49fef200abbf869b22017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00748-5https://doaj.org/toc/2041-1723Slow oscillations between cortical Up and Down states are a defining feature of deep sleep, but their function is not well understood. Here the authors study Up/Down states in acute slices of entorhinal cortex, and find that Up states promote the weakening of subthreshold synaptic inputs, while suprathreshold inputs are preserved or strengthened.Julian BartramMartin C. KahnSimon TuohyOle PaulsenTony WilsonEdward O. MannNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Julian Bartram Martin C. Kahn Simon Tuohy Ole Paulsen Tony Wilson Edward O. Mann Cortical Up states induce the selective weakening of subthreshold synaptic inputs
description	Slow oscillations between cortical Up and Down states are a defining feature of deep sleep, but their function is not well understood. Here the authors study Up/Down states in acute slices of entorhinal cortex, and find that Up states promote the weakening of subthreshold synaptic inputs, while suprathreshold inputs are preserved or strengthened.
format	article
author	Julian Bartram Martin C. Kahn Simon Tuohy Ole Paulsen Tony Wilson Edward O. Mann
author_facet	Julian Bartram Martin C. Kahn Simon Tuohy Ole Paulsen Tony Wilson Edward O. Mann
author_sort	Julian Bartram
title	Cortical Up states induce the selective weakening of subthreshold synaptic inputs
title_short	Cortical Up states induce the selective weakening of subthreshold synaptic inputs
title_full	Cortical Up states induce the selective weakening of subthreshold synaptic inputs
title_fullStr	Cortical Up states induce the selective weakening of subthreshold synaptic inputs
title_full_unstemmed	Cortical Up states induce the selective weakening of subthreshold synaptic inputs
title_sort	cortical up states induce the selective weakening of subthreshold synaptic inputs
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/d050c69f21184ee49fef200abbf869b2
work_keys_str_mv	AT julianbartram corticalupstatesinducetheselectiveweakeningofsubthresholdsynapticinputs AT martinckahn corticalupstatesinducetheselectiveweakeningofsubthresholdsynapticinputs AT simontuohy corticalupstatesinducetheselectiveweakeningofsubthresholdsynapticinputs AT olepaulsen corticalupstatesinducetheselectiveweakeningofsubthresholdsynapticinputs AT tonywilson corticalupstatesinducetheselectiveweakeningofsubthresholdsynapticinputs AT edwardomann corticalupstatesinducetheselectiveweakeningofsubthresholdsynapticinputs
_version_	1718390082462810112

Cortical Up states induce the selective weakening of subthreshold synaptic inputs

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