The impact of surgery on long-term survival of patients with primary intestinal non-Hodgkin lymphomas based on SEER database

The impact of surgery on long-term survival of patients with primary intestinal non-Hodgkin lymphomas based on SEER database

Abstract Evidence regarding the need for surgery for primary intestinal non-Hodgkin lymphoma (PINHL) patients with chemotherapy is limited and controversial. We aimed to investigate the specific impact of surgery on survival of PINHL patients. Data from PINHL patients (aged > 18 years) with chemo...

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Autores principales: Cuifen Zhang, Xiaohong Zhang, Zeyu Liu, Jiahao Tao, Lizhu Lin, Linzhu Zhai
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/d051ba7db7fc46a4b268b444eb953c93
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spelling oai:doaj.org-article:d051ba7db7fc46a4b268b444eb953c932021-12-05T12:14:07ZThe impact of surgery on long-term survival of patients with primary intestinal non-Hodgkin lymphomas based on SEER database10.1038/s41598-021-02597-12045-2322https://doaj.org/article/d051ba7db7fc46a4b268b444eb953c932021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-02597-1https://doaj.org/toc/2045-2322Abstract Evidence regarding the need for surgery for primary intestinal non-Hodgkin lymphoma (PINHL) patients with chemotherapy is limited and controversial. We aimed to investigate the specific impact of surgery on survival of PINHL patients. Data from PINHL patients (aged > 18 years) with chemotherapy between 1983 and 2015 were extracted from the Surveillance, Epidemiology, and End Results (SEER) database. We concerned about overall survival (OS) and improved cancer-specific survival (CSS). Propensity score matching (PSM) analysis was also used to explore the reliability of the results to further control for confounding factors. Finally, we screened 3537 patients. Multivariate regression analysis showed that patients with surgery and chemotherapy had better OS (hazard ratio [HR] 0.83; 95% confidence interval [CI] 0.75–0.93; p = 0.0009) and CSS (HR 0.87; 95% CI 0.77–0.99; p = 0.0404) compared with the non-operation group after adjusting for confounding factors. After PSM analysis, compared with non-surgery, surgery remained associated with improved OS (HR 0.77; 95% CI 0.68–0.87; p < 0.0001) and improved CSS (HR 0.82; 95% CI 0.72–0.95; p = 0.008) adjusted for baseline differences. In the large cohort of PINHL patients with chemotherapy older than 18 years, surgery was associated with significantly improved OS and CSS before and after PSM analysis.Cuifen ZhangXiaohong ZhangZeyu LiuJiahao TaoLizhu LinLinzhu ZhaiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Cuifen Zhang
Xiaohong Zhang
Zeyu Liu
Jiahao Tao
Lizhu Lin
Linzhu Zhai
The impact of surgery on long-term survival of patients with primary intestinal non-Hodgkin lymphomas based on SEER database
description Abstract Evidence regarding the need for surgery for primary intestinal non-Hodgkin lymphoma (PINHL) patients with chemotherapy is limited and controversial. We aimed to investigate the specific impact of surgery on survival of PINHL patients. Data from PINHL patients (aged > 18 years) with chemotherapy between 1983 and 2015 were extracted from the Surveillance, Epidemiology, and End Results (SEER) database. We concerned about overall survival (OS) and improved cancer-specific survival (CSS). Propensity score matching (PSM) analysis was also used to explore the reliability of the results to further control for confounding factors. Finally, we screened 3537 patients. Multivariate regression analysis showed that patients with surgery and chemotherapy had better OS (hazard ratio [HR] 0.83; 95% confidence interval [CI] 0.75–0.93; p = 0.0009) and CSS (HR 0.87; 95% CI 0.77–0.99; p = 0.0404) compared with the non-operation group after adjusting for confounding factors. After PSM analysis, compared with non-surgery, surgery remained associated with improved OS (HR 0.77; 95% CI 0.68–0.87; p < 0.0001) and improved CSS (HR 0.82; 95% CI 0.72–0.95; p = 0.008) adjusted for baseline differences. In the large cohort of PINHL patients with chemotherapy older than 18 years, surgery was associated with significantly improved OS and CSS before and after PSM analysis.
format article
author Cuifen Zhang
Xiaohong Zhang
Zeyu Liu
Jiahao Tao
Lizhu Lin
Linzhu Zhai
author_facet Cuifen Zhang
Xiaohong Zhang
Zeyu Liu
Jiahao Tao
Lizhu Lin
Linzhu Zhai
author_sort Cuifen Zhang
title The impact of surgery on long-term survival of patients with primary intestinal non-Hodgkin lymphomas based on SEER database
title_short The impact of surgery on long-term survival of patients with primary intestinal non-Hodgkin lymphomas based on SEER database
title_full The impact of surgery on long-term survival of patients with primary intestinal non-Hodgkin lymphomas based on SEER database
title_fullStr The impact of surgery on long-term survival of patients with primary intestinal non-Hodgkin lymphomas based on SEER database
title_full_unstemmed The impact of surgery on long-term survival of patients with primary intestinal non-Hodgkin lymphomas based on SEER database
title_sort impact of surgery on long-term survival of patients with primary intestinal non-hodgkin lymphomas based on seer database
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/d051ba7db7fc46a4b268b444eb953c93
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