Abiraterone acetate preferentially enriches for the gut commensal Akkermansia muciniphila in castrate-resistant prostate cancer patients

Abiraterone acetate (AA) is indicated for the treatment of patients with metastatic castrate-resistant prostate cancer. Here, the authors show that, in prostate cancer patients, orally administered AA remodels the gut microbiome and promotes the enrichment of the commensal bacterium Akkermansia muci...

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Autores principales:	Brendan A. Daisley, Ryan M. Chanyi, Kamilah Abdur-Rashid, Kait F. Al, Shaeley Gibbons, John A. Chmiel, Hannah Wilcox, Gregor Reid, Amanda Anderson, Malcolm Dewar, Shiva M. Nair, Joseph Chin, Jeremy P. Burton
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d057b42a310240ed8e3bbeaf06f35107
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spelling	oai:doaj.org-article:d057b42a310240ed8e3bbeaf06f351072021-12-02T18:14:16ZAbiraterone acetate preferentially enriches for the gut commensal Akkermansia muciniphila in castrate-resistant prostate cancer patients10.1038/s41467-020-18649-52041-1723https://doaj.org/article/d057b42a310240ed8e3bbeaf06f351072020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18649-5https://doaj.org/toc/2041-1723Abiraterone acetate (AA) is indicated for the treatment of patients with metastatic castrate-resistant prostate cancer. Here, the authors show that, in prostate cancer patients, orally administered AA remodels the gut microbiome and promotes the enrichment of the commensal bacterium Akkermansia muciniphila at the expense of androgen-utilizing Corynebacterium species.Brendan A. DaisleyRyan M. ChanyiKamilah Abdur-RashidKait F. AlShaeley GibbonsJohn A. ChmielHannah WilcoxGregor ReidAmanda AndersonMalcolm DewarShiva M. NairJoseph ChinJeremy P. BurtonNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Brendan A. Daisley Ryan M. Chanyi Kamilah Abdur-Rashid Kait F. Al Shaeley Gibbons John A. Chmiel Hannah Wilcox Gregor Reid Amanda Anderson Malcolm Dewar Shiva M. Nair Joseph Chin Jeremy P. Burton Abiraterone acetate preferentially enriches for the gut commensal Akkermansia muciniphila in castrate-resistant prostate cancer patients
description	Abiraterone acetate (AA) is indicated for the treatment of patients with metastatic castrate-resistant prostate cancer. Here, the authors show that, in prostate cancer patients, orally administered AA remodels the gut microbiome and promotes the enrichment of the commensal bacterium Akkermansia muciniphila at the expense of androgen-utilizing Corynebacterium species.
format	article
author	Brendan A. Daisley Ryan M. Chanyi Kamilah Abdur-Rashid Kait F. Al Shaeley Gibbons John A. Chmiel Hannah Wilcox Gregor Reid Amanda Anderson Malcolm Dewar Shiva M. Nair Joseph Chin Jeremy P. Burton
author_facet	Brendan A. Daisley Ryan M. Chanyi Kamilah Abdur-Rashid Kait F. Al Shaeley Gibbons John A. Chmiel Hannah Wilcox Gregor Reid Amanda Anderson Malcolm Dewar Shiva M. Nair Joseph Chin Jeremy P. Burton
author_sort	Brendan A. Daisley
title	Abiraterone acetate preferentially enriches for the gut commensal Akkermansia muciniphila in castrate-resistant prostate cancer patients
title_short	Abiraterone acetate preferentially enriches for the gut commensal Akkermansia muciniphila in castrate-resistant prostate cancer patients
title_full	Abiraterone acetate preferentially enriches for the gut commensal Akkermansia muciniphila in castrate-resistant prostate cancer patients
title_fullStr	Abiraterone acetate preferentially enriches for the gut commensal Akkermansia muciniphila in castrate-resistant prostate cancer patients
title_full_unstemmed	Abiraterone acetate preferentially enriches for the gut commensal Akkermansia muciniphila in castrate-resistant prostate cancer patients
title_sort	abiraterone acetate preferentially enriches for the gut commensal akkermansia muciniphila in castrate-resistant prostate cancer patients
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/d057b42a310240ed8e3bbeaf06f35107
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Abiraterone acetate preferentially enriches for the gut commensal Akkermansia muciniphila in castrate-resistant prostate cancer patients

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