Immunological history governs human stem cell memory CD4 heterogeneity via the Wnt signaling pathway

Immunological history governs human stem cell memory CD4 heterogeneity via the Wnt signaling pathway

Aging is associated with immune attrition that may impact the effectiveness of the immune system to protect the host from pathogens. Here the authors show that immune aging is associated with alterations in the Wnt/β-catenin signaling and reduced stem cell memory T lymphocytes, hinting the Wnt/β-cat...

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Autores principales: Hassen Kared, Shu Wen Tan, Mai Chan Lau, Marion Chevrier, Crystal Tan, Wilson How, Glenn Wong, Marie Strickland, Benoit Malleret, Amanda Amoah, Karolina Pilipow, Veronica Zanon, Naomi Mc Govern, Josephine Lum, Jin Miao Chen, Bernett Lee, Maria Carolina Florian, Hartmut Geiger, Florent Ginhoux, Ezequiel Ruiz-Mateos, Tamas Fulop, Reena Rajasuriar, Adeeba Kamarulzaman, Tze Pin Ng, Enrico Lugli, Anis Larbi
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Q
Acceso en línea:https://doaj.org/article/d05913b802064e6bbba5a639e2f712a7
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spelling oai:doaj.org-article:d05913b802064e6bbba5a639e2f712a72021-12-02T14:41:25ZImmunological history governs human stem cell memory CD4 heterogeneity via the Wnt signaling pathway10.1038/s41467-020-14442-62041-1723https://doaj.org/article/d05913b802064e6bbba5a639e2f712a72020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14442-6https://doaj.org/toc/2041-1723Aging is associated with immune attrition that may impact the effectiveness of the immune system to protect the host from pathogens. Here the authors show that immune aging is associated with alterations in the Wnt/β-catenin signaling and reduced stem cell memory T lymphocytes, hinting the Wnt/β-catenin pathway as a potential therapy target.Hassen KaredShu Wen TanMai Chan LauMarion ChevrierCrystal TanWilson HowGlenn WongMarie StricklandBenoit MalleretAmanda AmoahKarolina PilipowVeronica ZanonNaomi Mc GovernJosephine LumJin Miao ChenBernett LeeMaria Carolina FlorianHartmut GeigerFlorent GinhouxEzequiel Ruiz-MateosTamas FulopReena RajasuriarAdeeba KamarulzamanTze Pin NgEnrico LugliAnis LarbiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Hassen Kared
Shu Wen Tan
Mai Chan Lau
Marion Chevrier
Crystal Tan
Wilson How
Glenn Wong
Marie Strickland
Benoit Malleret
Amanda Amoah
Karolina Pilipow
Veronica Zanon
Naomi Mc Govern
Josephine Lum
Jin Miao Chen
Bernett Lee
Maria Carolina Florian
Hartmut Geiger
Florent Ginhoux
Ezequiel Ruiz-Mateos
Tamas Fulop
Reena Rajasuriar
Adeeba Kamarulzaman
Tze Pin Ng
Enrico Lugli
Anis Larbi
Immunological history governs human stem cell memory CD4 heterogeneity via the Wnt signaling pathway
description Aging is associated with immune attrition that may impact the effectiveness of the immune system to protect the host from pathogens. Here the authors show that immune aging is associated with alterations in the Wnt/β-catenin signaling and reduced stem cell memory T lymphocytes, hinting the Wnt/β-catenin pathway as a potential therapy target.
format article
author Hassen Kared
Shu Wen Tan
Mai Chan Lau
Marion Chevrier
Crystal Tan
Wilson How
Glenn Wong
Marie Strickland
Benoit Malleret
Amanda Amoah
Karolina Pilipow
Veronica Zanon
Naomi Mc Govern
Josephine Lum
Jin Miao Chen
Bernett Lee
Maria Carolina Florian
Hartmut Geiger
Florent Ginhoux
Ezequiel Ruiz-Mateos
Tamas Fulop
Reena Rajasuriar
Adeeba Kamarulzaman
Tze Pin Ng
Enrico Lugli
Anis Larbi
author_facet Hassen Kared
Shu Wen Tan
Mai Chan Lau
Marion Chevrier
Crystal Tan
Wilson How
Glenn Wong
Marie Strickland
Benoit Malleret
Amanda Amoah
Karolina Pilipow
Veronica Zanon
Naomi Mc Govern
Josephine Lum
Jin Miao Chen
Bernett Lee
Maria Carolina Florian
Hartmut Geiger
Florent Ginhoux
Ezequiel Ruiz-Mateos
Tamas Fulop
Reena Rajasuriar
Adeeba Kamarulzaman
Tze Pin Ng
Enrico Lugli
Anis Larbi
author_sort Hassen Kared
title Immunological history governs human stem cell memory CD4 heterogeneity via the Wnt signaling pathway
title_short Immunological history governs human stem cell memory CD4 heterogeneity via the Wnt signaling pathway
title_full Immunological history governs human stem cell memory CD4 heterogeneity via the Wnt signaling pathway
title_fullStr Immunological history governs human stem cell memory CD4 heterogeneity via the Wnt signaling pathway
title_full_unstemmed Immunological history governs human stem cell memory CD4 heterogeneity via the Wnt signaling pathway
title_sort immunological history governs human stem cell memory cd4 heterogeneity via the wnt signaling pathway
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/d05913b802064e6bbba5a639e2f712a7
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