In vitro evaluation of the effects of graphene platelets on glioblastoma multiforme cells

Slawomir Jaworski,1 Ewa Sawosz,1 Marta Grodzik,1 Anna Winnicka,2 Marta Prasek,1 Mateusz Wierzbicki,1 Andr&eacute; Chwalibog31Division of Biotechnology and Biochemistry of Nutrition, Faculty of Animal Science, 2Department of Pathology and Veterinary Diagnostics, Faculty of Veterinary Medicine...

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Autores principales:	Jaworski S, Sawosz E, Grodzik M, Winnicka A, Prasek M, Wierzbicki M, Chwalibog A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/d05bc1376cbf48d8b95b1a4f4503d6c2
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spelling	oai:doaj.org-article:d05bc1376cbf48d8b95b1a4f4503d6c22021-12-02T02:46:37ZIn vitro evaluation of the effects of graphene platelets on glioblastoma multiforme cells1176-91141178-2013https://doaj.org/article/d05bc1376cbf48d8b95b1a4f4503d6c22013-01-01T00:00:00Zhttp://www.dovepress.com/in-vitro-evaluation-of-the-effects-of-graphene-platelets-on-glioblasto-a12063https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Slawomir Jaworski,1 Ewa Sawosz,1 Marta Grodzik,1 Anna Winnicka,2 Marta Prasek,1 Mateusz Wierzbicki,1 Andr&eacute; Chwalibog31Division of Biotechnology and Biochemistry of Nutrition, Faculty of Animal Science, 2Department of Pathology and Veterinary Diagnostics, Faculty of Veterinary Medicine, Warsaw University of Life Sciences, Warsaw, Poland; 3Department of Veterinary Clinical and Animal Sciences, University of Copenhagen, Copenhagen, DenmarkAbstract: Graphene is a single atom-thick material with exciting potential. It can be used in many fields, from electronics to biomedicine. However, little is known about its toxicity and biocompatibility. Herein, we report a study on the toxicity of graphene platelets (GPs) by examining the influence of GPs on the morphology, mortality, viability, membrane integrity, and type of cell death of U87 and U118 glioma cells. It was found that graphene is toxic to glioma cells, but it activated apoptosis only in the U118 cell line, without inducing necrosis, indicating the potential applicability of GP in anticancer therapy.Keywords: toxicity, glioma, apoptosisJaworski SSawosz EGrodzik MWinnicka APrasek MWierzbicki MChwalibog ADove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2013, Iss default, Pp 413-420 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Jaworski S Sawosz E Grodzik M Winnicka A Prasek M Wierzbicki M Chwalibog A In vitro evaluation of the effects of graphene platelets on glioblastoma multiforme cells
description	Slawomir Jaworski,1 Ewa Sawosz,1 Marta Grodzik,1 Anna Winnicka,2 Marta Prasek,1 Mateusz Wierzbicki,1 Andr&eacute; Chwalibog31Division of Biotechnology and Biochemistry of Nutrition, Faculty of Animal Science, 2Department of Pathology and Veterinary Diagnostics, Faculty of Veterinary Medicine, Warsaw University of Life Sciences, Warsaw, Poland; 3Department of Veterinary Clinical and Animal Sciences, University of Copenhagen, Copenhagen, DenmarkAbstract: Graphene is a single atom-thick material with exciting potential. It can be used in many fields, from electronics to biomedicine. However, little is known about its toxicity and biocompatibility. Herein, we report a study on the toxicity of graphene platelets (GPs) by examining the influence of GPs on the morphology, mortality, viability, membrane integrity, and type of cell death of U87 and U118 glioma cells. It was found that graphene is toxic to glioma cells, but it activated apoptosis only in the U118 cell line, without inducing necrosis, indicating the potential applicability of GP in anticancer therapy.Keywords: toxicity, glioma, apoptosis
format	article
author	Jaworski S Sawosz E Grodzik M Winnicka A Prasek M Wierzbicki M Chwalibog A
author_facet	Jaworski S Sawosz E Grodzik M Winnicka A Prasek M Wierzbicki M Chwalibog A
author_sort	Jaworski S
title	In vitro evaluation of the effects of graphene platelets on glioblastoma multiforme cells
title_short	In vitro evaluation of the effects of graphene platelets on glioblastoma multiforme cells
title_full	In vitro evaluation of the effects of graphene platelets on glioblastoma multiforme cells
title_fullStr	In vitro evaluation of the effects of graphene platelets on glioblastoma multiforme cells
title_full_unstemmed	In vitro evaluation of the effects of graphene platelets on glioblastoma multiforme cells
title_sort	in vitro evaluation of the effects of graphene platelets on glioblastoma multiforme cells
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/d05bc1376cbf48d8b95b1a4f4503d6c2
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In vitro evaluation of the effects of graphene platelets on glioblastoma multiforme cells

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