A single cell characterisation of human embryogenesis identifies pluripotency transitions and putative anterior hypoblast centre

A single cell characterisation of human embryogenesis identifies pluripotency transitions and putative anterior hypoblast centre

Single cell analysis of early human embryos identifies key changes in pluripotency, the requirement of FGF signalling for embryo survival, and defines a putative anterior-like region of hypoblast cells, providing insights into how early human development is regulated.

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Auteurs principaux: Matteo A. Molè, Tim H. H. Coorens, Marta N. Shahbazi, Antonia Weberling, Bailey A. T. Weatherbee, Carlos W. Gantner, Carmen Sancho-Serra, Lucy Richardson, Abbie Drinkwater, Najma Syed, Stephanie Engley, Philip Snell, Leila Christie, Kay Elder, Alison Campbell, Simon Fishel, Sam Behjati, Roser Vento-Tormo, Magdalena Zernicka-Goetz
Format: article
Langue:EN
Publié: Nature Portfolio 2021
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Science
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Accès en ligne:https://doaj.org/article/d05c168f6b314658b4ceb906295bcd8b
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Résumé:Single cell analysis of early human embryos identifies key changes in pluripotency, the requirement of FGF signalling for embryo survival, and defines a putative anterior-like region of hypoblast cells, providing insights into how early human development is regulated.

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