A single cell characterisation of human embryogenesis identifies pluripotency transitions and putative anterior hypoblast centre

Single cell analysis of early human embryos identifies key changes in pluripotency, the requirement of FGF signalling for embryo survival, and defines a putative anterior-like region of hypoblast cells, providing insights into how early human development is regulated.

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Autores principales:	Matteo A. Molè, Tim H. H. Coorens, Marta N. Shahbazi, Antonia Weberling, Bailey A. T. Weatherbee, Carlos W. Gantner, Carmen Sancho-Serra, Lucy Richardson, Abbie Drinkwater, Najma Syed, Stephanie Engley, Philip Snell, Leila Christie, Kay Elder, Alison Campbell, Simon Fishel, Sam Behjati, Roser Vento-Tormo, Magdalena Zernicka-Goetz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d05c168f6b314658b4ceb906295bcd8b
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spelling	oai:doaj.org-article:d05c168f6b314658b4ceb906295bcd8b2021-12-02T16:04:16ZA single cell characterisation of human embryogenesis identifies pluripotency transitions and putative anterior hypoblast centre10.1038/s41467-021-23758-w2041-1723https://doaj.org/article/d05c168f6b314658b4ceb906295bcd8b2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23758-whttps://doaj.org/toc/2041-1723Single cell analysis of early human embryos identifies key changes in pluripotency, the requirement of FGF signalling for embryo survival, and defines a putative anterior-like region of hypoblast cells, providing insights into how early human development is regulated.Matteo A. MolèTim H. H. CoorensMarta N. ShahbaziAntonia WeberlingBailey A. T. WeatherbeeCarlos W. GantnerCarmen Sancho-SerraLucy RichardsonAbbie DrinkwaterNajma SyedStephanie EngleyPhilip SnellLeila ChristieKay ElderAlison CampbellSimon FishelSam BehjatiRoser Vento-TormoMagdalena Zernicka-GoetzNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Matteo A. Molè Tim H. H. Coorens Marta N. Shahbazi Antonia Weberling Bailey A. T. Weatherbee Carlos W. Gantner Carmen Sancho-Serra Lucy Richardson Abbie Drinkwater Najma Syed Stephanie Engley Philip Snell Leila Christie Kay Elder Alison Campbell Simon Fishel Sam Behjati Roser Vento-Tormo Magdalena Zernicka-Goetz A single cell characterisation of human embryogenesis identifies pluripotency transitions and putative anterior hypoblast centre
description	Single cell analysis of early human embryos identifies key changes in pluripotency, the requirement of FGF signalling for embryo survival, and defines a putative anterior-like region of hypoblast cells, providing insights into how early human development is regulated.
format	article
author	Matteo A. Molè Tim H. H. Coorens Marta N. Shahbazi Antonia Weberling Bailey A. T. Weatherbee Carlos W. Gantner Carmen Sancho-Serra Lucy Richardson Abbie Drinkwater Najma Syed Stephanie Engley Philip Snell Leila Christie Kay Elder Alison Campbell Simon Fishel Sam Behjati Roser Vento-Tormo Magdalena Zernicka-Goetz
author_facet	Matteo A. Molè Tim H. H. Coorens Marta N. Shahbazi Antonia Weberling Bailey A. T. Weatherbee Carlos W. Gantner Carmen Sancho-Serra Lucy Richardson Abbie Drinkwater Najma Syed Stephanie Engley Philip Snell Leila Christie Kay Elder Alison Campbell Simon Fishel Sam Behjati Roser Vento-Tormo Magdalena Zernicka-Goetz
author_sort	Matteo A. Molè
title	A single cell characterisation of human embryogenesis identifies pluripotency transitions and putative anterior hypoblast centre
title_short	A single cell characterisation of human embryogenesis identifies pluripotency transitions and putative anterior hypoblast centre
title_full	A single cell characterisation of human embryogenesis identifies pluripotency transitions and putative anterior hypoblast centre
title_fullStr	A single cell characterisation of human embryogenesis identifies pluripotency transitions and putative anterior hypoblast centre
title_full_unstemmed	A single cell characterisation of human embryogenesis identifies pluripotency transitions and putative anterior hypoblast centre
title_sort	single cell characterisation of human embryogenesis identifies pluripotency transitions and putative anterior hypoblast centre
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d05c168f6b314658b4ceb906295bcd8b
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A single cell characterisation of human embryogenesis identifies pluripotency transitions and putative anterior hypoblast centre

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