EXPERIMENTAL MEASLES VACCINES: A RESEARCH TOOL IN VACCINATION EVENTS

Abstract. The review article considers different variants of measles vaccine that may be classified into two groups, i.e., vaccines that do not contain viable measles virus, and attenuated measles vaccines which could be employed in unusual manner.The first group includes DNA-vaccines, recombinant v...

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Autor principal:	V. A. Liashenko
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	measles vaccine antibodies lymphocytes Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/d05c7455ef924da4878456f2cd52e9f6
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spelling	oai:doaj.org-article:d05c7455ef924da4878456f2cd52e9f62021-11-18T08:03:38ZEXPERIMENTAL MEASLES VACCINES: A RESEARCH TOOL IN VACCINATION EVENTS1563-06252313-741X10.15789/1563-0625-2007-1-7-14https://doaj.org/article/d05c7455ef924da4878456f2cd52e9f62014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/115https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. The review article considers different variants of measles vaccine that may be classified into two groups, i.e., vaccines that do not contain viable measles virus, and attenuated measles vaccines which could be employed in unusual manner.The first group includes DNA-vaccines, recombinant vaccine strains encoding synthesis of measles hemagglutinin and fusion protein, as well as peptide vaccines containing molecular fragments of these proteins. The mentioned variants of vaccines were effective in animal experiments, but they have not been tested in humans. The second group includes live attenuated mucosal measles vaccins applied in combination with immunomodulator(s), as aerosol and intranasally. Efficiency of these vaccines was tested and confirmed by immunization of children and adults. Mucosal measles vaccine induces local production of IgA measles antibodies, along with induced synthesis of circulating IgM and IgG antibodies against measles. The latter experimental variant could be a live attenuated measles vaccine containing some immunity-modulating agent. Elaboration of these variant was based on the known data about transient immunosuppressive activity of measles vaccine. An appropriate experimental variant represents a mixture of attenuated measles vaccine and synthetic immunomodulating agent (MP-2 peptide) which protects T-lymphocytes from inhibitory effect of the measles virus. In present revue, some data are presented concerning the mechanisms of immunogenic activity and adverse effects of measles vaccines.V. A. LiashenkoSPb RAACIarticlemeasles vaccineantibodieslymphocytesImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 9, Iss 1, Pp 7-14 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	measles vaccine antibodies lymphocytes Immunologic diseases. Allergy RC581-607
spellingShingle	measles vaccine antibodies lymphocytes Immunologic diseases. Allergy RC581-607 V. A. Liashenko EXPERIMENTAL MEASLES VACCINES: A RESEARCH TOOL IN VACCINATION EVENTS
description	Abstract. The review article considers different variants of measles vaccine that may be classified into two groups, i.e., vaccines that do not contain viable measles virus, and attenuated measles vaccines which could be employed in unusual manner.The first group includes DNA-vaccines, recombinant vaccine strains encoding synthesis of measles hemagglutinin and fusion protein, as well as peptide vaccines containing molecular fragments of these proteins. The mentioned variants of vaccines were effective in animal experiments, but they have not been tested in humans. The second group includes live attenuated mucosal measles vaccins applied in combination with immunomodulator(s), as aerosol and intranasally. Efficiency of these vaccines was tested and confirmed by immunization of children and adults. Mucosal measles vaccine induces local production of IgA measles antibodies, along with induced synthesis of circulating IgM and IgG antibodies against measles. The latter experimental variant could be a live attenuated measles vaccine containing some immunity-modulating agent. Elaboration of these variant was based on the known data about transient immunosuppressive activity of measles vaccine. An appropriate experimental variant represents a mixture of attenuated measles vaccine and synthetic immunomodulating agent (MP-2 peptide) which protects T-lymphocytes from inhibitory effect of the measles virus. In present revue, some data are presented concerning the mechanisms of immunogenic activity and adverse effects of measles vaccines.
format	article
author	V. A. Liashenko
author_facet	V. A. Liashenko
author_sort	V. A. Liashenko
title	EXPERIMENTAL MEASLES VACCINES: A RESEARCH TOOL IN VACCINATION EVENTS
title_short	EXPERIMENTAL MEASLES VACCINES: A RESEARCH TOOL IN VACCINATION EVENTS
title_full	EXPERIMENTAL MEASLES VACCINES: A RESEARCH TOOL IN VACCINATION EVENTS
title_fullStr	EXPERIMENTAL MEASLES VACCINES: A RESEARCH TOOL IN VACCINATION EVENTS
title_full_unstemmed	EXPERIMENTAL MEASLES VACCINES: A RESEARCH TOOL IN VACCINATION EVENTS
title_sort	experimental measles vaccines: a research tool in vaccination events
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/d05c7455ef924da4878456f2cd52e9f6
work_keys_str_mv	AT valiashenko experimentalmeaslesvaccinesaresearchtoolinvaccinationevents
_version_	1718422570061004800

EXPERIMENTAL MEASLES VACCINES: A RESEARCH TOOL IN VACCINATION EVENTS

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