A regulatory circuit of two lncRNAs and a master regulator directs cell fate in yeast

Transcription of lncRNAs is known to regulate local gene expression. Here the authors describe how orchestrated transcription of two contiguous lncRNAs facilitates a regulatory circuit by which the master regulator for entry into meiosis, IME1, directs the decision to enter meiosis in yeast.

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Detalles Bibliográficos
Autores principales: Fabien Moretto, N. Ezgi Wood, Gavin Kelly, Andreas Doncic, Folkert J. van Werven
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/d06124a5d36c4c2e86bd0405269e7881
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Sumario:Transcription of lncRNAs is known to regulate local gene expression. Here the authors describe how orchestrated transcription of two contiguous lncRNAs facilitates a regulatory circuit by which the master regulator for entry into meiosis, IME1, directs the decision to enter meiosis in yeast.